Term
|
Definition
| have receptors in almost every cell |
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Term
|
Definition
| inc glucose production at the expense of protein and muscle. |
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Term
|
Definition
| stimulates gluconeogenesis |
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|
Term
|
Definition
| cause hypergylcemia, and DM |
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|
Term
|
Definition
| stimulate storage of glucose in liver as glycogen. |
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Term
|
Definition
| induce lipolysis in extremities, and lipogenesis in trunkand face |
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Term
|
Definition
Catabolic effects:
thinning of skin, reduced mm mass |
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|
Term
|
Definition
| blcok action of calcitriol. used to treat hypercalcemia. |
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|
Term
|
Definition
| Anti-inflammation: reduce pain, heat redness, and swelling |
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Term
|
Definition
indirectly phospholipase a2 by inc lipocortin.
which blocks prod. of arachidonic acid. thus dec prostaglandins and leukotrienes |
|
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Term
|
Definition
| cause some vasoconstriction and inhibit release of histamine. |
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|
Term
|
Definition
| dec cell-mediated immunity. USed for a varitey of AI diseases |
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|
Term
|
Definition
|
|
Term
|
Definition
| long term use leads to osteoporosis, where as short term use treat hypercalcemia |
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Term
|
Definition
|
|
Term
|
Definition
| hepatic and renal metabolism |
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|
Term
|
Definition
|
|
Term
|
Definition
| only free drug can cross placenta, be metabolized and cross membrane. |
|
|
Term
|
Definition
|
|
Term
| synthetic glucocorticoids |
|
Definition
| used to treat inflammatory, AI, or allergic response |
|
|
Term
|
Definition
|
|
Term
|
Definition
| 4X as potent as cortisone |
|
|
Term
|
Definition
intermediate acting syn. glucocorticoid.
mainly used topically. |
|
|
Term
|
Definition
| 10X as potent as cortisol |
|
|
Term
| Dexamethasone and betamethasone |
|
Definition
| MOST POTENT syn. glucocorticoid. 25X as potent as cortisol |
|
|
Term
| Dexamethasone and betamethasone |
|
Definition
| better topically than triamcinolone, due to it being more hydrophilic |
|
|
Term
| Triamcinolone, dexamethasone, betamethasone |
|
Definition
| DONT have mineralocorticoid activity. |
|
|
Term
| declomethasone, budesonide, ciclesone, flunisolide, fluticasone, ,mometasone |
|
Definition
| Locally acting glucocorticoids. used mainly to prevent asthma or allergic rhinitis |
|
|
Term
| declomethasone, budesonide, ciclesone, flunisolide, fluticasone, ,mometasone |
|
Definition
| rapidly absorbed with few systemic SEs |
|
|
Term
| declomethasone, budesonide, ciclesone, flunisolide, fluticasone, ,mometasone |
|
Definition
| contain an ester at 17 position which is removed by esterase as soon as it enters blood. |
|
|
Term
| fluticasone/hydrocortisone |
|
Definition
| used as treatment for Addison's dse |
|
|
Term
|
Definition
| treats secondary adrenoinsuff. may need minerocorticoid as well, but depends on pt |
|
|
Term
|
Definition
| due to enzyme def. of 21B-hydroxylase. this causes dec cortisol and aldosterone |
|
|
Term
|
Definition
|
|
Term
|
Definition
| used to distinguish bw cushing dse and syndrome |
|
|
Term
|
Definition
| used in premature deliveries. has less protein binding so more can cross placentea and inc surfactant production. |
|
|
Term
|
Definition
aldosterone antagonist, inhibtis na resaborb. treats hypokalemia.
also blocks androgen receptor, leading to gynecomastia |
|
|
Term
|
Definition
| aldosterone antagonist, treats HTN and CHF |
|
|
Term
|
Definition
| glucocorticoid receptor antagonist, rapid dislocation of the drug leads to faulty translocation. |
|
|
Term
|
Definition
| used for aboriton in first 3 mo. and as morning after pill |
|
|
Term
| Mifepristone, ketoconazole, and metyrapone |
|
Definition
| experimentally used to treat cushings dse |
|
|
Term
|
Definition
antifungal that blocks synthesis of adrenal and gonadal steroids.
blocks synthesis of all 5 steroids |
|
|
Term
|
Definition
| only blocks cortisol synthesis |
|
|
Term
|
Definition
blocks 11B-hydroxylase.
inc secretion of 11-hydroxycortisone and androgens. |
|
|
Term
|
Definition
| AE: hirsutism and na retention |
|
|
Term
| synthetic glucocorticoids |
|
Definition
| inc half-life and DOA compared to cortisol. |
|
|
Term
| synthetic glucocorticoids |
|
Definition
| dec salt-retaining activity adn enhanced penetration of lipid barriers for topical use compared to cortisol |
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