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GI
test 3
38
Pharmacology
Graduate
10/28/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
Clarithromycin
Definition
Antibiotic- tolerance develops rapidly
Term
Amoxicillin
Definition
Antibiotic- 1st line therapy
Term
Metronidazole
Definition
Antibiotic- tolerance develops rapidly
Term
Tetracycline
Definition
Antibiotic
Term
Omeprazole (Priolosec)
Definition
Proton Pump Inhibitor- creates basic enviornment. drug interactions
Term
Rabeprazole (Aciphex)
Definition
Proton Pump Inhibitor- creates basic enviornment
Term
Lansoprazole (Prevacid)
Definition
Proton Pump Inhibitor- creates basic enviornment
Term
Pantoprazole (Protonix)
Definition
Proton Pump Inhibitor- creates basic enviornment
Term
Cimetidine (Tagamet)
Definition
H2 receptor antagonists, ↓ gastric acid secretion. OTC. Short t1/2. drug interactions! rarely elevate prolactin levels
Term
Ranitidine (Zantac)
Definition
H2 receptor antagonists, ↓ gastric acid secretion. OTC. longer acting, more potent
Term
Famotidine (Pepcid)
Definition
H2 receptor antagonists, ↓ gastric acid secretion. OTC. most potent
Term
Nizatidine (Axid)
Definition
H2 receptor antagonists, ↓ gastric acid secretion
Term
Rare condition in which a gastrin- producing tumor causes hypersecretion of HCL
Definition
Zollinger- Ellison Syndrome
Term
Prostaglandins
Definition
inhibit secretion of HCl and stimulate secretion of mucus & bicarbonate. less effective than H2 antagonists for acute treatment of PUD
Term
Misoprostol (Cytotec)
Definition
prostaglandin- approved for prevention of gastric ulcers induced by NSAIDs. CI in in pregnancy- abortifacient
Term
Antimuscarinic agents
Definition
↑ GI motility and secretory activity, use as adjuncts in management of PUD & Zollinger- Ellison syndrome
Term
Dycylomine (Bentyl)
Definition
Antimuscarinic agent
Term
Pirenzepine
Definition
antimuscarinic agent, specific M1 receptor antagonists, antisecretory agent
Term
PPI
Definition
H+/K+- ATPase proton pump inhibitors- supress secretion of the H+ ions into the gastric lumen. Direct antimicrobial action against H. Pylori
Term
Antacids
Definition
weak bases that react with gastric acid to form water & a salt- diminish gastric acidity, also diminishes pepsin activity, reduce H. Pylori
Term
Aluminum & Magnesium (Maalox)
Definition
antacid- promote healing of duodenal ulcers
Term
Calcium salts (TUMS)
Definition
antacid- stimulate gastrin release
Term
Sodium Bicarbonate (Alkaseltzer)
Definition
antacid- systemic absorption of can produce transient metablic alkalosis- no long term use
Term
mucosal protective agents
Definition
cytoprotective actions that enhance mucosal protection mechanisms heal existing duodenal (not gastric) ulcers
Term
Sucralfate (Carafate)
Definition
complex of aluminum hydroxide & sulfated sucrose- forms gels, produces protective barrier. does not work with antacids, H2 antagonists, or PPI
Term
Bismuth Subsalicylate (Pepto Bismal)
Definition
effectively heals peptic ulcers, w. antimicrobial actions. inhibit activity of pepsin, ↑ mucus secretion. also used in antidiarrheals
Term
Metoclopramide (Reglan)
Definition
substitutied Benxamide- antiemetic, antidopaminergic
Term
Prochlorperazine (Compazine)
Definition
Phenothiazine- antiemetic- blocks dopamine receptors
Term
Haloperidol (Haldol)
Definition
Butyropenones- antiemetic. block dopamine receptor, moderately effective
Term
Droperidol (Inapsine)
Definition
Butyropenones- antiemetic. block dopamine receptor, moderately effective
Term
Granisetron (Kytril)
Definition
antiemetic-5HT3 serotonin receptor blockers in brain and periphery
Term
Ondansetron (Zofran)
Definition
antiemetic-5HT3 serotonin receptor blockers in brain and periphery
Term
Lorazepam (Ativan)
Definition
benzodiazepine- antiemetic, low potency, more sedative, anziolytic anmesic. useful in anticipatory vomiting
Term
Alprazolam (Xanax)
Definition
benzodiazepine- antiemetic, low potency, more sedative, anziolytic anmesic. useful in anticipatory vomiting
Term
Dexamethazone (Decadron)
Definition
corticosteroid also used as antiemetic. for mild to moderate
Term
Methylprednisolone (Medrol)
Definition
corticosteroid also used as antiemetic. for mild to moderate
Term
Aprepiant (Emend)
Definition
Substance P/ Neurokinin 1 receptor blocker- only used against moderate to high emetics. j
Term
Dronabinol (Marinol)
Definition
cannabinoid- antiemetic, marijuana derivatives effective against moderate emetogenic chemotherapy
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