Term
| Pancreatic exocrine component makes up what part of the gland and produces how much fluid? |
|
Definition
|
|
Term
| Pancreatic endocrine component (10%) is composed of _____. |
|
Definition
| Islets of Langerhans - secrete hormones into circulation via pancreatic vein |
|
|
Term
| Pancreas is retro or intra peritoneal? |
|
Definition
|
|
Term
| The head is located in the _____ and the tail extends to the _____ of the spleen. |
|
Definition
| duodenal concavity ; hilum |
|
|
Term
| Like the liver, the pancreas develops as an outgrowth of the _____. |
|
Definition
|
|
Term
| The main pancreatic duct (aka Duct of Wirsung) is composed of fused ducts from the ____ and _____ anlage. |
|
Definition
|
|
Term
| Main pancreatic duct begins in the ____ and continues down the length of the organ. |
|
Definition
|
|
Term
| Main pancreatic duct is lined by ____ epithelium with goblet cells. |
|
Definition
|
|
Term
| There is a large reserve of exocrine pancreas function. More than ____ of these cells must be damaged before maldigestion signs seen. |
|
Definition
|
|
Term
| The pancreas is a _____ gland. |
|
Definition
|
|
Term
These are intra-canard ducts - the origin of the intercalated ducts
Unique to the pancreas.
Appear as pale cells within acini. |
|
Definition
|
|
Term
| Each _____ cell is capable of producing about 20 different enzymes or zymogens. |
|
Definition
|
|
Term
| Pancreatic ducts are not _____ (as opposed to the salivary gland). |
|
Definition
|
|
Term
Cells lining the _____ ducts secrete water and bicarb ions.
(ductular cells) |
|
Definition
|
|
Term
| The digestive fluid secreted by the exocrine pancreas is _____ and _____ (pH >8.0). |
|
Definition
|
|
Term
|
Definition
| enzyme-rich secretions by acinar cells |
|
|
Term
| acidic chyme -> secretin -> |
|
Definition
| watery, bicarb-rich secretions by ductal cells |
|
|
Term
A cells - Glucagon
Increases blood glucose levels |
|
Definition
20% of islet cells
more peripherally located in islet
dense core granules are round, uniform, have a clear halo |
|
|
Term
| B cells - insulin -> decreases blood glucose levels |
|
Definition
70% of islet cells
centrally located throughout islets |
|
|
Term
|
Definition
5% of islet cells
inhibits other islet cells (paracrine effect)
slows motility of intestinal tract (extends digestion and absorption time) |
|
|
Term
|
Definition
| pancreatic polypeptide, rare cells |
|
|
Term
The surgical removal of the gall bladder.
Common procedure. |
|
Definition
|
|
Term
Gallstones, formed when solid concentrations of cholesterol/lipid act as node for Ca deposition.
10-15% adults may have small ones.
Large ones can cause obstructive jaundice, cholecystitis, pancreatitis, etc. |
|
Definition
|
|
Term
Disease of uncertain cause
ongoing inflammation, destruction, fibrosis of intrahepatic and extrahepatic bile ducts.
Leadds to cirrhosis, portal hypertension, liver failure. |
|
Definition
| Primary sclerosing cholangitis |
|
|
Term
uncommon, 10% mortality
autodigestion by activated proteolytic enzymes is pathogenesis.
blood tests may show increased levels of certain enzymes leaking into blood. |
|
Definition
|
|
Term
90% patients depend on pancreatic enzyme supplements.
Results in dilated (cystic) ducts with surrounding fibrosis. |
|
Definition
|
|
Term
|
Definition
|
|
Term
form of cancer involving B cells of islets
may be functional tumors resulting in unregulated insulin hypersecretion and symptoms of hypoglycemia |
|
Definition
|
|
