Term
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Definition
| -found in close living quarters like camp and transmitted by contaminated food or fecal-oral route and leads to acute infection |
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Term
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Definition
| -transmitted by needle stick, blood, breast milk, sex and leads to acute and/or chronic infection |
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Term
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Definition
-leading cause of chronic hepatitis, cirrhosis and HCC.
-5 viral proteins
-1 million deaths annually |
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Term
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Definition
| Capsid Ag seen in liver biopsy |
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Term
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Definition
| Variant see during peak phase of infection |
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Term
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Definition
surface Ag. Abs against this Ag indicate the dz has resolved or a chronic infection
-can be admin by a recombinant vaccine |
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Term
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Definition
| can be detected 1 week post infection |
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Term
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Definition
- affects hepatocytes only (narrow tropism)
-initiate humoral response (MHC I and CTL respond to peptides from HBc An and HBe Ag present on infected cell surface) |
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Term
| HBV acute infection (3 outcomes) |
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Definition
1. Anti HBs Abs and Anti HBc Ab for resolution
2. Chronic Dz due to limited immune response (asympt carrier, chronic persistant or chronic active)
3. Fulminant Hepatitis- lethal if coinfected |
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Term
| Hep B passive immunization |
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Definition
| -admin preformed Ab to HBs Ag (HepB Immunoglobulin) then immediately follow with actual vaccine |
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Term
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Definition
-needs surface Ag from HBV to be infective
-can have a super-infection with pt w/ chronic Hep B (leads to severe acute hep, chronic dz, HCC and cirrhosis) |
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Term
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Definition
-infection lasts about 8 weeks
-good prognosis: no chronic or persistent infections
-unchecked, virus can hav outbreaks/fatalities
-prevention: inactive and attenuated viral vaccine, improved hygiene |
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Term
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Definition
-6 genotypes transmitted by body fluids/blood
-dz lasts years, decades
-25% get an acute infec and either resolve or progress to chronic Hep C
-75% get subclinical infec progressing to chronic Hep C over 15 years ending in lever failure or HCC
-HIV and EtOH abuse accelerate sxs |
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Term
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Definition
-clinically identical to Hep A
-no chronic carrier state
-sxs: malaise, anorexia, abd pain, arthralgia, fever
-2-9 week incubation; dz is mild, resolves in 2 weeks, no sequelae
-20% fatality in pregnant women |
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Term
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Definition
-often seen on cruise ships transmitted via contaminated food, water, ppl
-sxs: secretory diarrhea, n/v, fever, myalgias x 24-48 hours
*chief cause of viral GE epidemics |
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Term
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Definition
-stable in low pH, can replicate in GT tract and is excreted in stool
-90% of non-polio ___________ viruses cause asymptomatic infection or undifferentiated febrile illness
-no FDA tx- give antipyretics |
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Term
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Definition
-enterovirs; some shed in feces, some travels to blood causing asymptomatic viremia then moves to bone marrow, liver and spleen (can override adap immune response causing secondary viremia with sxs)
-only 1% dev paralysis |
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Term
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Definition
-enteroviruses that cause meningitis, URIs, GE, pericarditis, myocardidtis, sev. sore throat, pleurisy
-transmitted via dirt, feces, resp droplets |
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Term
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Definition
-sever CNS dz
-contagious hemorrhagic conjunctivitis Type 70 |
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Term
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Definition
-accounts for 40% of sev diarrhea cases in kids <2 yrs old (Jan-March)
-infective particles are naked/stable
-has segmented genome: reassortment
-infects SI Jejunum, resistant to stomach pH
-secretory diarrhea (lose electrolytes)
-48 hour incubation |
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