Term
| 5-aminosalicylate mechanism |
|
Definition
| Inh COX and LOX, reducing inflammatory mediators |
|
|
Term
| Aluminum hydroxide side effects |
|
Definition
Constipation
Nephrotox
Myopathy
Weakens bone |
|
|
Term
|
Definition
diminished GI effects
worse for renal fx |
|
|
Term
|
Definition
Liquids more effective
Rx interactions |
|
|
Term
|
Definition
Sodium bicarbonate
Calcium carbonate
Magnesiusm hydroxide
Aluminum hydroxide |
|
|
Term
|
Definition
neutralize acid, Do not inh secretion
Raise pH from 1 to 3.5
Short duration |
|
|
Term
| Anthraquinone side effects |
|
Definition
cramping
may get into breast milk
Lazy bowel synd a/w abuse |
|
|
Term
|
Definition
| Laxative that increases secretion of fluid |
|
|
Term
|
Definition
Act on emesis centers:
Chemoreceptor trigger zone on floor of 4th ventricle (5HT, DA, and opiod rec)
Solitary Tract nucleus (hist, ACH, 5HT rec) |
|
|
Term
|
Definition
H1 Antihistamines
Metoclopramide
Phenothiazines
Ondansetron
Marijuana
Glucocorticoids |
|
|
Term
|
Definition
|
|
Term
|
Definition
Forms bismuth oxychloride and salicylic acid in stomach acid. Bismuth travels thru int, but salicylate is absorbed.
Thought to be antisecretory/inflammatory/bacterial |
|
|
Term
|
Definition
| Blackens the stool and may darken the tongue |
|
|
Term
|
Definition
traveler's diarrhea
H pylori combo rx |
|
|
Term
|
Definition
Rapid onset, long duration
Constipation
Acid rebound
Gas
Alkalosis |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Laxative that inc secretion of fluid |
|
|
Term
| Diphenylmethanes side effects |
|
Definition
Phenolphthalein is carcinogenic (withdrawn)
Bisacodyl requires hydrolysis
Can cx bowel inflammation |
|
|
Term
|
Definition
Dopamine receptor antagonist
Prokinetic |
|
|
Term
|
Definition
Enhances ACh release by antagonizing inh effect of DA on cholinergic nn to GI mm
Inh emesis via chemoreceptor zone in CNS and in stomach |
|
|
Term
|
Definition
Gastroparesis
N/V from dysmotility |
|
|
Term
|
Definition
THC
Stimulates rec in or around emesis center |
|
|
Term
| Dronabinol adverse effects |
|
Definition
1. Central sympathomimetic
2. Highs
3. Paranoid rxns
4. Abstinence syndrome (irritability, insomnia, restlessness) |
|
|
Term
| Dronabinol pharmacokinetics |
|
Definition
Highly lipid soluble (detectabe for several weeks
Readily absorbed p.o.
Large vol of distribution |
|
|
Term
|
Definition
emesis
stim appetite in AIDS and anorexia |
|
|
Term
|
Definition
PPI or H2 ant + amoxicillin + clarithromycin or metronidazole
PPI +tetracycline + bismuth + metronidazole
7 day rx |
|
|
Term
| Histamine H2 antagonist adverse effects |
|
Definition
| Gynecomastia and impotence in males taking hi doses of cimetidine |
|
|
Term
| Histamine H2 antagonist mech |
|
Definition
Reversibly competes w histamine for H2 rec on basolateral memb of parietal cells
Most effective against nocturnal secretion (duodenal ulcers)
Effects dose-related |
|
|
Term
| Histamine H2 antagonist problems (2) |
|
Definition
1. Tolerance (not a prob w PPIs)
2. Acid rebound (terminal dosage should be tapered) |
|
|
Term
| Histamine H2 antagonist uses (3) |
|
Definition
1. promote healing of gastric and duodenal ulcers
2. Rx uncomplicated GERD
3. Prophylaxis of stress ulcers |
|
|
