Term
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Definition
Aluminum silicate/ Absorbent
Cycloprotective
Inhibits absorption of other drugs |
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Term
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Definition
| Binds bacterial toxins and has cycloprotective effect |
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Term
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Definition
5-HT3 Antagonist
Use for Female Diarrhea-IBS ONLY
AE: ischemic Colitis |
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Term
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Definition
opioid
Activates NO and VIP release which stimulates non-propulsive Motility
AE: constipation |
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Term
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Definition
Opioid
Doesn't penetrate BBB |
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Term
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Definition
alpha-2 Agonist
Decrease in GI motility and secretion
AE: Constipation, Dry mouth, dizziness, rash, withdrawal effects |
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Term
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Definition
TCA - Blocks NE and 5HT uptake
Used for IBS
AE: Cardiac Dysrhythmias |
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Term
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Definition
TCA
Blocks 5HT reuptake
Use for Depression and Diarrhea |
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Term
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Definition
TCA
Blocks 5HT reuptake
Use for Depression and Diarrhea |
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Term
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Definition
Cholinergic Agonist
Increase gut motility and secretion
Contraction of bladder detrusor
Use for post surgical ileus
AE: diarrhea, Caution in Asthma
Use orally |
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Term
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Definition
Act at motilin receptors
Stimulates contraction
Use Post Surgical Ileus |
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Term
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Definition
Acetylcholinesterase inhibitor
AE: Bad Cholinergic ones |
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Term
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Definition
Dopamine Receptor Antagonist
This increases ACh release
No Effect on GI motility
Treats disorders of Gastric Emptying, Improves antroduodenal coordination
Increases LES
AE: Not approved in US |
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Term
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Definition
Blocks Dopamine receptors on cholinergic nerves, and 5HT on enteric nerves
Enhances antroduodenal coordination
Simulates large and small bowel motility
Crosses BBB
Also Useful as an anti emetic
AE: Extrapyramidal Side Effects |
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Term
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Definition
Opioid Antagonist
Does not cross BBB
Used to treat post-operative Ileus
Won't interfere with pain management |
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Term
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Definition
Opioid Antagonist
Does not cross BBB
Used to treat post-operative Ileus
Won't interfere with pain management |
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Term
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Definition
Bulk Forming Laxative
Increases Bulk and water content
(osmotic effect)
Multiple days needed for action
Used to soften feces for pts with hemorrhoids, hernia or CV disease. |
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Term
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Definition
Bulk Forming Laxative
Increases Bulk and water content
(osmotic effect)
Multiple days needed for action
Used to soften feces for pts with hemorrhoids, hernia or CV disease. |
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Term
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Definition
Bulk Forming Laxative
Increases Bulk and water content
(osmotic effect)
Multiple days needed for action
Used to soften feces for pts with hemorrhoids, hernia or CV disease. |
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Term
| Magnesium Citrate (Sulfate) |
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Definition
Saline osmotic Laxative
Fast acting, works by increases osmotic gradient
Used before endoscopy or rad exam
CI: Renal Failure |
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Term
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Definition
Saline osmotic Laxative
Fast acting, works by increases osmotic gradient
Used before endoscopy or rad exam
Also Lowers colonic pH reducing ammonia reabsorption |
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Term
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Definition
Stimulant Laxative
Direct stimulant of water and electrolyte secretion by increasd cAMP
Leaky tight junctions
6-8 hours for effect
Can be abused |
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Term
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Definition
Senna and Cascara
Stimulant Laxative that can also directly simulate motility |
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Term
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Definition
Chloride Channel Activator
Stimulate water movement into the lumen, increases motility, and Lubricating effects
Used for Constipation |
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Term
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Definition
DA receptor Antagonist (Phenothiazine)
Also blocks histamine and muscarinic
Used to treat Chemo,opiate emesis
AE: Extra-Pyramidal Side Effects |
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Term
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Definition
Dopamine Antagonist (Butyrephenone)
Inhibits NST, and CTZ
AE: EPS |
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Term
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Definition
Dopamine Antagonist (Butyrephenone)
Inhibits NST, and CTZ
AE: EPS, QT elongation |
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Term
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Definition
5HT antagonist
Blocks 5HT on afferent nerve endings in GI mucosa
Used to treat chemo-induced emesis
Very effective, Few side effects |
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Term
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Definition
5HT antagonist
Blocks 5HT on afferent nerve endings in GI mucosa
Used to treat chemo-induced emesis
Very effective, Few side effects |
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Term
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Definition
5HT antagonist
Blocks 5HT on afferent nerve endings in GI mucosa
Used to treat chemo-induced emesis
Very effective, Few side effects |
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Term
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Definition
Anti-Emetic properties unknown
Potentate actions of other antiemetic agents |
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Term
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Definition
Anti-emetic
acts on Cannabinoid receptors in area postrema and NTS to inhibit signaling
Appetite simulation
AE: High |
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Term
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Definition
Histamine Antagonist
Blocks H2 receptors on parietal cells reducing cAMP decreasing H secretion
AE: Anti-Androgenic effects, can inhibit P450 |
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Term
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Definition
Histamine Antagonist
Blocks H2 receptors on parietal cells reducing cAMP decreasing H secretion |
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Term
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Definition
Histamine Antagonist
Blocks H2 receptors on parietal cells reducing cAMP decreasing H secretion |
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Term
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Definition
Histamine Antagonist
Blocks H2 receptors on parietal cells reducing cAMP decreasing H secretion |
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Term
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Definition
Proton Pump Inhibitor
Blocks H/K ATPase
Used for PUD, GERD, Dyspepsia
AE: decreased B12 absorption |
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Term
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Definition
Proton Pump Inhibitor
Blocks H/K ATPase
Used for PUD, GERD, Dyspepsia
AE: decreased B12 absorption |
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Term
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Definition
Proton Pump Inhibitor
Blocks H/K ATPase
Used for PUD, GERD, Dyspepsia
AE: decreased B12 absorption |
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Term
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Definition
PGE2 analog
Decreases acid secretion by decreasing cAMP levels in parietal cells
Stimulates bicarb secretion
Increases Mucosal Blood Flow
AE: Abortion |
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Term
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Definition
Forms protective barrier at ulcer margins to promote healing
Negatively charged gel with high affinity for exposed glycoproteins |
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Term
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Definition
Antacid
Fast Acting Short duration
AE: hypercalcemia, excessive gastrin and HCl secretion |
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Term
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Definition
Antacid
Moderate Onset, Short Duration
Can cause diarrhea, osmotic laxative |
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Term
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Definition
Antacid
Slow Acting, Long Duration
Produces constipation |
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Term
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Definition
Antacid
Can cause metabolic alkalosis |
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Term
Somatostatin
(Octreotide) |
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Definition
NT release inhibitor
Inhibits gastrin, CCK, Hisatime, GH/IGF-1, and Serotonin secretion
Used to treat Carcinoid syndrome, Diarrhea, GI bleeding |
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Term
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Definition
| B2 block, unopposed alpha vasoconstriction of mesentaric arteries, used for esophageal varicies/portal HTN. AE: bronchospasm, bradycardia, prolonged PR |
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Term
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Definition
| analgesic, opite receptor mu and kappa agonist. AE: tremor, seizure |
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Term
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Definition
| mineralcorticoid recp antagonist, androgen and aldosterone block. Used w/ furosemide for ascities. AE: peptic ulcers, hyperkalemia, metabolic acidosis |
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Term
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Definition
| NSAID, pain/inflamation, COX inhibitor/PGE2 synthesis inhibition. AE: GI bleeding, ulcer, salicylism (ears,liver,kidney toxicity) |
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Term
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Definition
| NSAID, pain/inflamation, COX inhibitor/PGE2 synthesis inhibition. AE: GI bleeding, ulcer, salicylism (ears,liver,kidney toxicity) |
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Term
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Definition
| herbal, antidote for death cap mushcroom (amanita phalloides) treat hep B AE: laxative |
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Term
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Definition
| herbal, unknown mechanism/useless, used for hep C. AE: hypoglycemia, sleep disturbance |
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Term
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Definition
| liver protectant, HS radicatls neutralize toxic metabolites acetaminophen. AE: IV anaphylaxis |
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Term
| S-adenosylmethoinine (SAM) |
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Definition
| precursor glutathione, protection to oxidative stress. SAM low in EtOH liver. |
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Term
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Definition
| exocrine enzyme replacement (lipase, amylase, protease), enteric coated used for pancreatic insufficiency, non enteric coated reduces pain in chronic pancreatitis. AE: hyperuricemia. |
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Term
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Definition
| monoclonal TNF-alpha Ab, treat crohns disease. AE: increased risk infections, req TB testing |
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Term
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Definition
| 5-ASA, Azo-linked dimer 5-ASA cleaved with bacteria. AE: hepatotoxicity, bone marrow suppresion, watery diarrhea |
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Term
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Definition
| 5-ASA treat chrohns, COX inhibitor/anti chemotaxic to PMNs. better than sulfasalazine. |
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Term
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Definition
| converted to sulfapyridine and 5-ASA, treat ulcerative colitis. AE: hepatoxicity, bone marrow suppression. |
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Term
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Definition
| glucocorticoid, treat IBD AE:peptic ulcer, pancreatitis, infections |
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Term
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Definition
| glucocorticoid, treat IBD. AE: infections, peptic ulcer, pancreatitis |
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Term
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Definition
| Calcineurin inhibitor, Crohns, inhibits calcineurin to decrease IL2 AE: nephrotoxic, hyperkalemia |
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Term
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Definition
| folic acid anatagonist blocks THF synthesis by inhibiting DHFR, treat IBD and leukemia/lymphomas. AE: accumulates in fluid, edema, bone marrow suppression, hepatix toxicity, renal failure. Leocovorin rescue. |
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Term
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Definition
| metabolized into 6-mercaptopurine inhibit purine synthesis. Treat IBD AE: jaundice/hepatoxic, bone marrow suppression DI: allopurinol inhibits metabolism |
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Term
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Definition
| inhibit purine synthesis. Treat IBD AE: jaundice/hepatoxic, bone marrow suppression DI: allopurinol inhibits drug metabolism |
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Term
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Definition
| nucleoside reverse transcriptase inhibitor, hep B. AE: resistance 20%/yr, hepatotoxic. |
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Term
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Definition
| nucleic acid inhibition, guanosine analog. Hep C AE: hemolysis, myelosuprression, teratogenic |
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Term
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Definition
| inhibit peptide chain initiation and elongation, NK activation, stimulate degrade mRNA. AE: thrombocytopenia, bone marrow suppression |
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Term
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Definition
| fluroquinolone, inhib NDA synthesis/gyrase and topoisomerase. Use for g- and UTI. AE: arthropathy and joint development (children) tendonitis, long QT. |
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Term
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Definition
| glycopeptide, inhibit cell wall synthesis. c. difficile. AE: flushing nephrotoxic, ototoxic |
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Term
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Definition
| Anti protozoal, nitro radicals DNA breaks,used for c. diff and amebiasis/giardiasis. AE: neurotxic, nausea, cystitis. |
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Term
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Definition
| Macrolide, 50s ribosome. used for h.pylori. AE: hepatitis, otoxicity, arrythmias. |
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Term
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Definition
| b-lactam, inhibit transpeptidase/cell wall peptidoglycan cross link, treat h. pylori AE: neurotoxicity, sizure, platlet dys, allergy (Steven Johnson syndrome, angioedema) |
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Term
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Definition
| 30s ribosome, treat h.pylori AE: teeth brown/hyoplasia (children), photosensitive |
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