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GI Pharma
GI Pharma
15
Medical
Graduate
05/19/2011

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Cards

Term
Cimetidine
Definition
H2 blocker (others: ranitidine, famotidine, nizatidine)
Mech: reversible H2 block → decr. parietal cell H+ excr 
Tox: cimetidine crosses BBB (confusion, dizzy, h/a) & placenta; cemetidine has antiandrogen effects (incr. Prl, gynecomastia, decr. libido) cimetidine & ranitidine decr. Cr excr
Interactions: Cimetidine (-) P-450
Term
Omeprazole
Definition
PPIMech: irrev inhib H/K pump in parietal cellsUse: ulcer, GERD, Z-E synd
Term
Lansoprazole
Definition
PPIMech: irrev inhib H/K pump in parietal cellsUse: ulcer, GERD, Z-E synd
Term
Bismuth
Definition
Mech: binds ulcer base for protection; allows HCO3- secr to re-establish pHUse: ulcers, triple therapy" for H.py (metro + amox/tet + bismuth)"
Term
Sucralfate
Definition
Mech: binds ulcer base for protection; allows HCO3- secr to re-establish pH
Term
Misoprostol
Definition
PGE1 analogMech: incr. prod. & secr of gastric mucus barrier; decr. acid prod.
Use: prevent NSAID ulcers; maintenance of PDA; labor induction
Tox: diarr; abortions (contra: women of childbearing potential)
Term
Pirenzepine
Definition
M antagMech: blocks M1 on ECL cells (decr. His) & M3 on parietal cells (decr. H+)
Use: ulcer
Tox: anti-parasymp SE
Term
Propantheline
Definition
M antag
Mech: blocks M1 on ECL cells (decr. His) & M3 on parietal cells (decr. H+)
Use: ulcer
Tox: anti-parasymp SE
Term
Aluminum hydroxide
Definition
Antacid
Tox: constip & hypophos; prox m. weakness, osteodystrophy, seizures
Note: all antacids can affect abs, bioavail, or urinary excr of drugs
Term
Mg hydroxide
Definition
AntacidTox: diarr, hyperreflexia, hypoTN, cardiac arrest
Note: all antacids can affect abs, bioavail, or urinary excr of drugs
Term
Calcium carbonate
Definition
Antacid
Tox: hypercalcemia, rebound incr. acid; can chelate/decr. effect of other drugs (ie: tet)
Note: all antacids can affect abs, bioavail, or urinary excr of drugs
Term
Infliximab
Definition
MAb vs. TNF
Use: Crohn's, RA
Tox: resp infxn (ie: reactiv. of TB), hypoTN
Term
Sulfasalazine
Definition
Sulfapyridine (AB) + mesalamine (anti-inflam)
Mech: activated by colon bact.
Use: UC, Crohn's
Tox: sulfa tox, reversible oligospermia
Term
Ondansetron
Definition
5-HT3 antag
Mech: central-acting antiemetic
Use: control postop/chemo vomiting
Term
Metoclopramide
Definition
Prokinetic agent - D2 antag
Mech: incr. resting tone, contractility, LES tone, motility; no change in colon transport t
Use: DM & postop gastroparesis
Tox: Parkinsonian effectsInteract: digoxin & DM drugs
Contra: pts w/ SI obstr
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