Term
Are slow-acetylators common?
Do rapid Acetylators exist?
What are common drugs affected by acetylator type? |
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Definition
Slow Acetylators: Yes, 50% of US
Fast acetylators: Yes
Hydralazine
Isoniazid
Sulfamethazine
Dapsone |
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Term
What drug is affected by alterations in the pseudoplasmaesterases?
Is a defect in pseudoplasma esterases common?
How do you test for the mutation?
Is it commonly tested for? |
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Definition
Succynyl Choline
Not common: 0.04%
Test: Dibucaine inhibits by mutated protein less
Not commoly tested, only asked in the history
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Term
What are the drugs metabolized by CYP2D6?
What are some things to consider before starting a drug metabolized by CYP2D6 with a patient having a mutation?
What is the effect of the mutation on codiene? |
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Definition
Antidepressants
Anti-Psychotics
Beta-Blockers
Anti-Arrythmics
Opiods
Factors to consider
Therapeudic Index
Competitive inhibition of other drugs metabolized by the CYP2D6
Risks of Inducing Saturable Kinetics
Codiene: Less effect |
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Term
Mutation in CYP2C19 would effect what drugs?
What population is it highest in? |
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Definition
Mephenytoin
Clopidogrel
Population: asians |
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Term
| What are common drugs metabolized by CYP2C9 |
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Definition
Warfarin
Phenytoin
Losartan
Tolbutamide(Sulfonylurea for DM)
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Term
What is the significance of G-6-P deficiency in drug interactions?
What populations is it associated with? |
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Definition
Sulfonamides and Anti-Malarial cause hemolytic anemia in these patients
Ethnicity: African or Mediterranean |
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Term
| What is the significance of TPMT Deficiency? |
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Definition
Patients of Azathioprine cannot break down 6-mercaptopurine causing Myelosuppression
Enhanced by Allupurinol bc alternative degradation occurs through xanthine oxidase
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