Term
What is the mechanism of Albendazole?
What worms is it affective against?
What are the side effects?
What is the active metabolite? |
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Definition
Mech: blockage of microtubules and glucose metabolism
Worms:
Hookworms
Pork Tapeworms
Pinworms
Adverse
Marrow suppression in immunosupressed*
Peptic Ulcer Disease
BP decrease
Liver Cirrhosis
Active: Sulfoxide |
|
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Term
What is the mechanism of Mebendazole?
What worms is it effective against?
What are the adverse effects? |
|
Definition
Mech: blockage of microtubules and glucose metabolism
Worms:
Hookworm
Pinworm
Whipworm
Trichinosis
Adverse
Alopecia*
Hypersensitivity*(Stephen Johnson's)
High Protein Binding
Profuse Diarrhea
Elevated Liver Enzymes |
|
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Term
What is the mechanism of Pyrantel Pamoate?
What worms is it effective against?
What are the adverse effects |
|
Definition
Mech: Neuromuscular block(like curare)
Worms
Hookworm
Roundworm
Adverse
Profuse Diarrhea
Liver Problems |
|
|
Term
What is the mechanism of Praziquantel?
What worms is it effective against?
What are the adverse effects? |
|
Definition
Mech: Increase membrane permeability causing Ca efflux and motor halt
Worms
Tapeworms
Flukes(Schistosomia)
Adverse
Seizures
Myalgia
Severe Diarrhea
Liver problems |
|
|
Term
| Which anti-helmintic has the shortest half life and how can it be exteneded |
|
Definition
Praziquantel
Carbohydrate diet |
|
|
Term
| Which anti-helmintics have poor oral absorption |
|
Definition
Albendazole
Mebendazole
Pyrantel pamoate |
|
|
Term
| What are the major anti-helmintic drugs |
|
Definition
Albendazole
Mebendazole
Pyrantel Pamoate
Praziquantel
|
|
|
Term
Which Anti-helmintic Causes:
Myalgia
Alopecia
Marrow Suppression in immunosuppressed
Seizures
Peptic Ulcers
Stephen's Johnsons's
|
|
Definition
Myalgia: Praziquantel
Alopecia: Mebendazole
Marrow Suppression in immunosuppressed:
Albendazole
Seizures: Praziquantel
Peptic Ulcers: Albendazole
Stephen's Johnsons: Mebendazole |
|
|
Term
Drug of choice for:
Tapeworms
Whipworms
Pinworms
Trichinosis
Flukes |
|
Definition
Tapeworms: Praziquantel
Whipworms: Mebendazole
Pinworms: Albendazole and Mebendazole
Trichinosis: Albendazole and Mebendazole
Flukes: Praziquantel |
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