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GI PHARM
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22
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Kindergarten
04/12/2013

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Cards

Term
H2 blockers (4)
Definition
Cimitidine
Ramitidine
Famotidine
Nizatidine
(all end in -tidine)
Term
H2 blocker MOA
Definition
Reversible block of histamine H2 receptors found in Pariatel cells of the stomach
Term
H2 blocker Clinical Uses
Definition
Peptic Ulcers
GERD
ZE syndrome
Term
H2 Blocker Sides (2)
Definition
P450 INHIBITOR
Antiandrogenic (gyno and decreased libido
Term
Proton Pump Inhibitors (2) and what are their MOA
Definition
Omeprazole
Lansoprazole

IRREVERSIBLY inhibits H/K ATPase
Term
Proton Pump Inhibitor USE
Definition
H. Pylori
ZE syndrome
GERD
Peptic Ulcer
Term
Proton Pump Inhibitor SE
Definition
Inhibits P450
Decrease bioavailibility of weak acids (your making stomach basic)
Term
Drug requires Acidic pH to work, allows HCO3- secretion to reestablish pH gradient
Definition
Sucralfate
Term
Bismuth and Sucralfate USE
Definition
Ulcer healing
Travelers Diarrhea
BMT-H. pylori
Term
PGE1 analog to increase gastric mucous barrier
Definition
Misoprostol
Term
Misoprostol USE
Definition
NSAID INDUCED ULCERS
PDA maintenance
Arbortifacient
Term
Long Acting Somatostatin analogue
Definition
Octreotide
Term
Uses of Octreotide
Definition
Acute variceal bleed
Acromegaly
VIPoma
Carcinoid Tumors
Term
Aluminum Antacid SE (3)
Definition
1. Constipation
2. Hypokalemia
3. seizures
Term
Magnesium Antacid SE (4)
Definition
1. Diarrhea
2. Decrease Reflux
3. Hypotension
4. Hypokalemia
Term
Calcium Carbonate Antacid SE (3)
Definition
1. Hypercalcemia
2. Rebound Acid Increase
3. Hypokalemia
Term
Opioid drug used for Diarrhea
Definition
Loperamide
Term
Ondensetron MOA and USE
Definition
5HT3 antagonist of (Area Postrena and GI)

Chemo center/GI antiemetic
Term
Prohclorperazine/Metoclopramide MOA and USE
Definition
D2 antagonist (Area Postrena)
Chemo centeer antimetic
Term
Muscarinic antagonist used as antiemetic and what center does it work on
Definition
Scopolamine at the vestibular center
Term
H1 antagonists Antiemetics (3) and what system does it work on ?
Definition
Diphenhydramine
Meclizine
Promethazine

At vestibular system
Term
Antiemetic which blocks substance P, Nk1 receptor antagonist
Definition
Aprepitant
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