Term
| What are the effects on Free fraction, Drug clearance, total concentration, and free concentration if a drug is displaced without altering metabolism versus displaced with metabolic inhibition? |
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Definition
Without Metabolic Inhibiton
Free Fraction: Increase
Clearance: Increase
Total Concentration: Decrease
Free Concentration: Transient Increase
With Metabolic Inhibition
Free Fraction: Increase
Clearance: Decrease
Total Concentration: Increase
Free Concentration: Increase |
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Term
| The clearance of what drug is inhibited by smoking? |
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Definition
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Term
Drugs that prolong the QT interval?
(risk for torsades de points) |
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Definition
Albuterol
Chloroquine(malaria)
Pregnisolone
Furosemide
Fluroquinolones
Phenothiazines(Anti-psychotics)
TCA
Class 1a Antiarrhythmics:
Procainamide
Quinidine
Disopyramide
Class III Antiarrhythmics:
Amiodarone
Sotalol
Ilbitilide |
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Term
| What is the risk of SSRI's with MAO-I's |
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Definition
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Term
What should not be used with Gemfibrozil?
Why?
What is the mecahnism of Gemfibrozil? |
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Definition
Lova, Cervisa, Atorva, Simvastatin
Rhabdomyolysis
Mech: Fibrates induce PPAR-alpha increasing lipoprotein lipase production
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Term
| What Cytochrome P450 isozyme metabolisms more than 50% of drugs? |
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Definition
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Term
| What drugs should not be giving with anacids? |
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Definition
Ketoconazole: Needs Acid
Quinolones: Ca or Mg
Tetracyclines: Aluminum |
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Term
| What is the most problematic protease inhibitor for drug-drug interactions? |
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Definition
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