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GI Pathophysiology - Upper GI
Pathology of the GI tract
22
Physiology
Undergraduate 3
12/12/2013

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Cards

Term
Name two processes that the oral cavity and/or pharynx is involved in
Definition
1. Mastication and swallowing (deglutition)
2. Initiation of transition between voluntary and involuntary control systems
Term
What can cause pathology of the upper GI system?
Definition
1. Opportunistic infection
2. Poor oral hygiene
Term
(T/F) Only bacteria can opportunistically infect the upper GI
Definition
False, both fungi and bacteria
Term
List 3 things that can allow for opportunistic infection
Definition
- Immune suppression
- Diabetes
- Antibiotic use
Term
List two consequences of opportunistic infection
Definition
- Apthous ulcers - Thrush
Term
How does poor oral hygiene contribute to pathology of the upper GI?
Definition
- Promotes infections of the peridontium
- Allows for gingivitis (gum disease)
Term
Which 3 components of the nervous system regulate swallowing
Definition
- CNS
- Vagus nerve (ANS)
- Intrinsic innervation
Term
List the voluntary actions of swallowing
Definition
Term
List the involuntary actions of swallowing
Definition
Trygeminal and pharyngeal nerves initiate complex sequence of events
Term
What is dysphagia?
Definition
Difficulty swallowing
Term
List 3 functional pathologies of the esophagus
Definition
- Dysphagia
- Achalasia
- Atresia
Term
What is seen in achalasia, and what causes it?
Definition
- Failure in propulsion
- Lower ES relaxation
- Due to defect in intrinsic inhibitory innervation
Term
What is atresia?
Definition
Developmental failure - incomplete esophagus
Term
(T/F) GERD is a pathology that arises from inflammation
Definition
True
Term
(T/F) Drugs usually correct this
Definition
True
Term
What is GERD?
Definition
Gastro-esophageal reflux disease
Term
What is the primary symptom?
Definition
Pain (either acute or chronic)
Term
What 3 things cause it?
Definition
1. Relaxed LES
2. Excessive acid production
3. Hiatial hernia
Term
What is a hiatal hernia?
Definition
Protrusion of the upper stomach through the diphragm
Term
What pathology is associated with GERD?
Definition
- Barrett's esophagus (destruction of epithelium in esophagus)
- Increased CA risk
Term

(T/F) Adenocarcinoma of the esophagus and proximal stomach is increasing, whilst squamous cell carcinoma of esophagus, and gastric carcinoma is decreasing

 

Definition
True
Term
Why is adenocarcinoma increasing? Why are gastric cancers and squamous epithelial cancers increasing?
Definition

Increase: GERD and obesity

Decrease: tobacco use, alcohol consumption, dietary factors

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