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GI-Path
Liver Pathology II
18
Pathology
Graduate
02/15/2011

Additional Pathology Flashcards

 


 

Cards

Term

What hepatitis viruses are spread by the fecal-oral route

Which has no carriers, no chronic disease, and no carcinoma risk

Definition
HepA and Hep E
Term

What are the presentations of Hep B?

What age group develops the most  chronic infections with Hep B?

Definition

Presentations

Acute

Fulminant

Chronic

Age Group: Neonates

Term
What is required for hepD infection
Definition
Previous HepB infection
Term
What is the most common cause of Chronic Hepatitis and hepatocellular Carcinoma
Definition
HepC
Term
Histology of acute viral hepatitis
Definition

Disarray(Structure)

Necrosis with Ballooning degeneration

Inflammation(past limiting plate)

Regeneration(binucleate cells)

Term
What does grade and stage describe in chronic hepatitis
Definition

Grade: level of...

Necrosis

Lobar activity

Portal inflammation

Stage:

Severity of fibrosis None->Portal->Bridging->Cirrhosis

Term

What are the pathological stages of alcoholic fatty liver disease and the pathology of each?

What zone does it start in?

Definition

Fatty Liver: zone 3

Alcoholic Steatohepatitis:

necrosis

inflammation

mallory hyaline

perivenular fibrosis

Cirrhosis: thick bridging fibrosis

Term
What is the pathogenesis of alcoholic steatosis?
Definition

Increased Fatty Acid Synthesis

Decreased Beta oxidation

Increased Triglycerides

Impaired lipoprotein release

 

Term

What is the cause of primary biliary cirrhosis?

What are the pathological stages?

What are the markers?

What sex is it more common in?

What other diseases it it seens with

Definition

Autoimmune disease more common in women

Markers: Anti-Mitochondrial, Elevated IgM

Associations: 85% have another autoimmune disease

Stages

I: Granulomas, small and medium duct destruction, inflammation

II: Periportal inflammation

III: Bridging Fibrosis

IV: Cirrhosis

Term

What disease is primary sclerosing cholangitis associated with?

What antibody is seen?

What is the risk?

What sex is affected?

What are the pathological Features

Definition

Ulcerative Colitis

P-ANCA

Cholangiocarcinoma

Males

Pathology

Activity near bile duct

Onion Skining Fibrosis

Term

What is the cause of Hereditary Hemochromatosis and

What are the major signs

What is the HLA association?

Definition

AR HFE gene(chromosome 6) mutation linked to HLA-A3

Signs

Skin Pigmentation

Diabetes

Cirrhosis and Hepatocellular Carcinoma

Chondrocalcinosis of MCP and PIP

Dialated Cardiomyopathy

Infections: Vibro, Yersina, Listeria

Term

What is wilson's disease?

What are the major signs?

Definition

AR in Cu-atpase on chromosome 13

Signs

KF lesions

Cirrhosis

Neurological Signs

Fanconi Syndrome

Term
How does CF effect the liver of a neonate
Definition
obstructive jaundice
Term

What is the most common genetic cause of liver disease in infants and children?

What are the liver manifestations?

What is seen pathologically?

What forms cause emphysema and liver cirrhosis?

Definition

Alpha-1 anti-trypsin deficiency

Manfestations

Hepatitis

Cholestasis

Hepatocellular carcinoma

Pathology: PAS(+) inclusion bodys

Emphysema: PiSZ, PiSS

Cirhosis: PiZZ

Term
what people are particularly suseptible to Hep E
Definition
Pregnant women
Term

What sex is autoimmune hepatitis common in?

What anti-bodies are associated with the disease?

Definition

Women

Anti-SM, ANA, Increased IgG

Term
What are some causes for NAFL or NASH
Definition

Diabetes

Obesity

Corticosteroids

Kwashiorkor

Term

What are the serological markers of the following diseases?

Celiac Sprue

Autoimmune Hepatits

PBC

PSC

GIST tumor

Hepatocellualar Carcinoma

Pancreatic Cancer

Definition

Anti-tTG

Anti-SM, ANA, and Elevated IgG

Anti-Mitochondrial and high IgM with

P-ANCA with Jaundice

cKIT

alpha-Fetoprotein

CA19-9 and CEA

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