Term
| Virulence factors for shigella |
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Definition
Shiga toxin: AA-tRNA receptor site block
Homology: EHEC verotoxin (Cytotoxin)(shiga-like toxin)
Carried by lysogenic phage
Invasive Plamid Antigens
Type III secretion
Endotoxin |
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Term
| Which bacteria have type III and Type IV secretion systems |
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Definition
Type III: E.coli, Shigella, Salmonella, Yersina, Vibrio
Type IV: Legionella pneumophilia, H. pylori |
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Term
| Virulence factors of Salmonella |
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Definition
Motile
Facultative Intracellular
Invasins: epithelial invasion
Vi Antigen: Anti-phagocytic
Type III secretion
Endotoxin |
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Term
What is the laboratory test results of C. jejuni
How is it differentiated from cholera? |
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Definition
Curved Gram(-) Rods
Oxidase (+)
Microaerophic, Requires specialized media and 2-3 day culture in 42 C
Cholera is from tropical areas with high volume diarrhea every 30 minutes
Jejuni:
Foul smelling wartery diarrhea, 3 per day
Followed by bloody stools and fever |
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Term
| What is a severe complication of Camplyobacter infection and how is it caused? |
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Definition
Guillian-Barre Syndrome
Caused By: LPS Type II hypersensitivity with Glycosphingolipids of the myelin |
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Term
| What are the major causes of infectious tenesmus |
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Definition
Shigella
Enteramoeba histolitica |
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Term
| What is the typical presentation of Shigella |
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Definition
Diarrhea for 2-3 days
Followed by low volume diarrhea and sometimes Dysentery(mucus, blood, tenesmus) |
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Term
Which species of shigella is the rarest and which is more common in children?
Which species most commonly cause Bacillary Dysentary? |
|
Definition
dysenteriae: Rarest
sonnei: Children
Dysentery: sonnei, flexneri |
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Term
| What are the major lab characteristics of Shigella? |
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Definition
| (-) Rod, Non-Lactose, H2S (-), Non-motile |
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Term
| What are the lab characteristics of Salmonella |
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Definition
| (-) Rod, Non-Lactose, H2S(+), Motile |
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Term
| Which enteric bacteria are true pathogens |
|
Definition
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Term
| What are the major clinical syndromes of enteric salmonella infection and what subspecies are typical of each? |
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Definition
Typhoid Fever(typhi-worst, paratyphi A or B)
1st week-Systemic(fever, aches, lethargy)
Blood (+) Culture
2nd week- Rose Spots maybe, Ab pain, fever
Blood/Stool Culture
3rd week- Diarrhea, blood stool
Stool (+) Culture
Carrier state(rare)
Bone, Joint, Liver, Meninges(rare)
Marrow (+) Cultures
Enterocolitis(enteritidis, typhimurium)
Poultry/Eggs
Nausea vomiting, Self-limiting
Bacteremia with Focal Lesions(choleraesuis)
Bacteremia-> Osteomyelitis, Pneumonia, Meningitis
Blood (+) culture
Sickle Cell Patients* |
|
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Term
| What foods commonly cause salmonellla enterocolitis |
|
Definition
|
|
Term
| What patients are more suseptible to bacteria with focal lesions caused by Salmonella |
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Definition
|
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Term
| Where can cultures be obtained in each of the salmonella forms of disease |
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Definition
Enterocolitis: Stool
Typhoid Fever: Wk 1/2-blood, Wk 2/3-stool, Wk 4 Urine, sometimes marrow
Bacteria w/ focal lesions: blood |
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Term
| How can a salmonella diagnosis be confirmed |
|
Definition
Differential/Selective Media, Biochmeistry or Agglutination
Widal Test: agglutination
|
|
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Term
| When is salmonella infection treated with antibiotics? |
|
Definition
Typhoid fever
Bacteremia with focal Lesions |
|
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Term
What is the pathology of Yersinia enterolytica, pseudotuberculosis infections?
What age group does enterolytica typically affect and what toxin does it possess? |
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Definition
Mucosal damage w/ enlarged mesenteric nodes
enterolytica affects children
enterolytica has E.coli-like ST toxin(cGMP) |
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Term
| How is Shiga toxin acquired |
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Definition
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|
Term
| Are there vaccines for typhoid fever? |
|
Definition
YES
Attenuated and Killed |
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