Term
| Which IBS disease is more genetically tied |
|
Definition
|
|
Term
What age group does IBD affect
What sex is UC more common in?
Which is associated with smoking |
|
Definition
15-25 or some 55-60
CD(smoker's)
UC: Women |
|
|
Term
|
Definition
Genetic suseptibility
Antigenic stimulation
Improper Down regualtion of activated lamina propria |
|
|
Term
| What is the genetic suseptibility for Crohn disease |
|
Definition
| NOD2 Mutation on Chromosome 16 |
|
|
Term
What are the major pathologies of Crohn disease
How do you monitor the inflammation? |
|
Definition
Deep ulcerations
Granulomas
Skip Areas
Fistulas
Perforations
Inflammation: CRP, or ESR |
|
|
Term
| What are the major symptoms of crohn disease and Ulcerative Colitis |
|
Definition
Crohn
Crampy Pain
Diarrhea
Fever
Weight Loss
Ulcerative Colitis
Crampy Pain
Bloody Diarrhea
Tenesmus(Constant feeling of bowel urgency) |
|
|
Term
Extraintestinal manifestations of IBD?
Which do not respond to treatment |
|
Definition
Ankylosing Spondilitis-No response
Migrating Large Joint Arthritis
Erythema Nodosum
Pyoderma Gangrenosum
Episcleritis and Uveitis
Primary Sclerosing Cholangitis(UC)-No response |
|
|
Term
What are the medications used for IBD?
What is the indication of each? |
|
Definition
Aminosalicylates(Mesalamine) Enema or Oral
Use: Mild/Moderate Chron's/UC
Corticosteroids:Never w/ ABSESSES
Use: short-term control, not with absesses
Antibiotics(metronidazole):
Use: Severe Suppurative, Absesses, Fistulas
Immunomodulators(Azthioprine, 6-Mecaptopurine):
Use: Added to steroids if exhascerbations prevent steroid withdrawal
Biologicals:
Use: Fistulas/Resistant Crohn
Not determined in UC |
|
|
Term
| What are the surgical procedures to alleviate IBD |
|
Definition
Ileostomy
Ileoanal J-Pouch |
|
|
Term
| What IBD has a high recurrance rate after surgery |
|
Definition
|
|
Term
| What IBD has a high risk of colon cancer and what is the screening protocol |
|
Definition
Ulcerative colitis
Frequent and multiple biopsies for dysplasia after 8-10 years with the disease |
|
|
Term
| Where in the colon are obstructions most likely to occur and why? |
|
Definition
Sigmoid colon
Diameter is much smaller |
|
|
