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GI Hormones
GI
66
Medical
Professional
11/23/2013

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Cards

Term
what family does gastrin belong to
Definition
gastrin
Term
what is the source of gastrin
Definition
antral G cells (G17)
Term
what stimulates gastrin
Definition
vagus (GRP), partially digested proteins, amino acids
Term
where does gastrin bind
Definition
to the CCK-B receptor
Term
what does gastrin stimulate
Definition

gastric acid secrection 

gastric and interstinal mucosal growth 

Term
what part of gastric mucosal is not stimulated by gastrin
Definition
antrum
Term
what family does cholecystokinin belong to
Definition
gastrin
Term
what is the source of CCK33
Definition
small intestine
Term
what is the source of CCK8
Definition
the brain
Term
what stimulates CCK release
Definition
fatty acids, amino acids, H+, CCK releasing factor
Term
what inhibits gastrin
Definition

somatostatin 

acid in antrum

Term
what inhibits CCK
Definition

absorption of stimulants

digestion of CCK releasing factor by trypsin

Term
where does CCK bind to
Definition
CCK-A receptor
Term
what does CCK stimulate
Definition

pancreastic enzymes

contraction of the gall bladder

stimulation of pancreatic growth

relaxation of orad stomach

contraction of pylorus leading to decreased gastric emptying 

Term
what family does secretin belong to
Definition
secretin
Term
what is the source of secretin
Definition
small intestine
Term
what stimulates secretin
Definition

H+ 

also fatty acids

Term
what inhibits secretin
Definition
neutralization of stimulant
Term
what does secretin stimulate
Definition

pancreatic, hepatic, and intestinal bicarbonate secretion

cholerectic

growth of the pancreas

Term
what does gastrin inhibit
Definition
gastric acid secrection
Term
what family does VIP belong to
Definition
secretin
Term
what is the source of VIP
Definition
neural tissue
Term
what stimulates VIP
Definition
acetylcholine (nicotonic)
Term
what inhibits VIP
Definition
lack of stimulant
Term
what does VIP inhibit
Definition
inhibition of smooth muscle contraction
Term
what happen in a VIPoma
Definition

increase in bicarbonate secretion from pancreas and intestine 

inhibits gastric acid secretion 

Term
what family does GIP
Definition
small intestine
Term
what stimulates GIP
Definition
fatty acids, amino acids, carbohydrates
Term
what inhibits GIP
Definition
absorption of stimulant
Term
what are the actions of GIP
Definition
glucose dependent insulin release
Term
what does GIP inhibit
Definition
gastric acid secretion
Term
what family does glucagon belong to
Definition
secretin
Term
what is the source of glucagon
Definition
pancreas
Term
what stimulates glucagon
Definition
low blood sugar levels
Term
what is the action of glucagon
Definition
increase blood sugar levels
Term
what family goes GLP-2 belong to
Definition
secretin
Term
what is the source of GLP-2
Definition
intestinal L cells
Term
what stimulates GLP-2
Definition
meal
Term
what inhibtits GLP-2
Definition
absorption of stimulant
Term
what does GLP-2 stimulate
Definition
growth of intestinal mucosal tissue
Term
how does GLP-2 effect the ileal
Definition
it causes and inhibition of gastric acid and pancreatic secretion
Term
what does GLP-2 inhibit
Definition
bone reabpsorption
Term
what family does GLP-1 belong to
Definition
secretin
Term
what is the source of GLP-1
Definition
L cells of the intestine
Term
what stimulates GLP-1
Definition
meal
Term
what does GLP-1 enhance
Definition
glucose dependent insulin secretion
Term
what does GLP-1 inhibits
Definition

glucagon release

gastric secretion and motility

Term
what does GLP-1 increase
Definition
insulin sensitivity
Term
what family does pancreatic polypeptide belong to
Definition
NPY family
Term
what is the source of pancreatic polypeptide
Definition
small intestine
Term
what stimulates pancreatic polypeptide
Definition
meal
Term
what is the action of pancreatic polypeptide
Definition
reduces pancreatic secretion by 10% during a meal
Term
what family does peptide YY belong
Definition
NPY family
Term
what is the source of peptide YY
Definition
lower intestine
Term
what stimulates peptide YY
Definition
after a meal
Term
what inhibits peptide YY
Definition
absorption of stimulant
Term
what are the actions of peptide YY
Definition

 decrease appetite via hypothalamus

inhibtion of ghrelin secrection

Term
what family does motillin belong to
Definition
motillin
Term
what is the source of motillin
Definition
small intestine
Term
what stimulates motillin
Definition
neural
Term
what is motillin associated with
Definition
MMC
Term
what family does ghrelin belong to
Definition
motillin
Term
what is the source of motillin
Definition
stomach
Term
what inhibits ghrelin
Definition
ingestion of a meal
Term
what are ghrelin actions
Definition

orexigenic (increase appetite)

increase GH secretion

may protect mucosal from injury

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