Shared Flashcard Set

Details

GI drugs
For the GI block quiz, 12/7/09
9
Medical
Graduate
12/06/2009

Additional Medical Flashcards

 


 

Cards

Term
HAV vaccine
Definition
  1. Antibodies develop 2-3 wks, booster 6-12 months after initial dose.
  2. Indicated in travelers, health care providers, military personal, populations at high risk
  3. IM immunoprophylaxis
Term
HBV vaccine
Definition
Recombinant vaccine. Three IM injections. Booster not recommended unless immunosuppressed. If exposed, give vaccine of antibody levels are <10 mIU/ml
Term
Lamivudine and adefovir
Definition

Used for chronic hep B. Nucleoside analog activated in vivo. Requires lower doses than HIV due to higher effect.

 

Competitively inhibits HBV reverse transcriptase, causes termination after incorporation.

Term
Entecavir and telbivudine
Definition

Nucleoside analogue of guanosine

 

Used in chronic HBV, inactive against HIV. Lower incisdence of drug resistance, with higher effectivity compared to lamivudine and adefovir

Term
What is the standard treatment for HCV? What are some factors associated with favorable response? Side effects? Counter indications?
Definition
  1. Pegylated interferon alfa 2b and ribovarin
  2. HCV genotype 2 and 3, abscence of cirrhosis, low pre-treatment HCV RNA levels
  3. Flu like symtpoms within 6 hours; thrombocytopenia, granulocytopenia, high neuropsychiatric effect
  4. Psychosis, depression, neutropenia, decompensated cirrhosis, uncrontrolled seizures, organ transplant
Term
Dicyclomine and hyosycamine
Definition

Anti-spasmodics (anticholinergic) for diarrhea-related IBS

 

Used infrequently due to side effects (dry mouth, visual iurbance, urinary retention)

Term
Alosetron
Definition

Used for diarrhea releated IBS. Serotonin antagonist. Longer duration than other 5-HT3.

 

SEVERE side effects (constipation in 30%), ischemic colitis (0.3%)

Term
Tegaserod
Definition
Partial 5-HT4 agonist (resembles serotonin). Used in constipation IBS. Relieves pain and stimulates peristalsis. Well-tolerated.
Term
Ursodial
Definition
Bile acid used to treat gallstones. Dissolves small cholesterol gallstones.
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