Term
| #1 Triple therapy H-pylori |
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Definition
Clarithromycin, amoxicillin, omeprazole
SKIN RASH NOT ALWAYS ALLERGY to amoxicillin
peripheral neuropathy, disulfiram reaction to alcohol
Clarithro may cause GI upset |
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Term
| H-pylori therapy allergic penicillin |
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Definition
| Clarithromycin, metroniadazol, ompeprazol |
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Term
| quadruple therapy H-pylori |
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Definition
Metronidazol, tetracylin, omeprazole, bismuth subsalicate
Tetracylin may be hepatoxic and effect bone structure |
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Term
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Definition
Proton pump inhibitor
absorbed in the small intestine, secreted into acid caniliculus, converted to OM-sulfonemide, blocks H/K-ATPase
COVALENT AND IRREVERSIBLE!!!!!
remember proton pumps move into lumen in response to meal therefore TAKE 30-60 MINS PRIOR EATING
METABOLIZED AND INHIBITS CYP2C19!! GENETIC DEFICIENCY MAY BE PRESENT
INCREASES RESPIRATORY INFECTION AND DECREASES B12 + potential rebound hypersecretion
may inhibit ketoconazol and digoxin absorbtion
CLOPIDOGREL ALSO CYP2c19 THEREFORE MAY CAUSE BUILDUP |
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Term
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Definition
Zantac - H2 receptor antagonist
OK 1 large dose/day
Confusion, depression, hallucinations in elderly
Hepatic and renal excretion |
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Term
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Definition
H2 receptor antagonist
ok 1 large dose/day
hepatic and renal secretion
Confusion, depression, hallucinations in elderly
Inhibits some CYp450's
ANTI-ANDROGENETIC |
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Term
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Definition
simple buffer
Mg++ causes diarrhea then CNS
Al+++ causes constipation and hypophosphotemia
Na+ = sodium retention
CO3 --> CO2 plus gas
HCO3 --> systemic alkylosis
Ca2+ --> calcium supplement |
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Term
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Definition
cytoprotective agent
may stimulate pge
causes black tongue or black feces
salicylate allergy |
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Term
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Definition
In acidic pH, forms viscous, paste-like layer protecting
mucosal cells. STIMULATED PGE PRODUCTION
PPI reduce efficacy
SAFE IN PREGNANCY
CONTAINS ALUMINUM |
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Term
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Definition
Synthetic PGE which stimulated bicarb and mucous secretion
ABORTIFACTIVE
least effective except for NSAID USE |
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Term
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Definition
is a prodrug – converted to mesalamine
(5ASA) & sulfapyridine by bacteria
does NOT act like aspirin via COX acetylation
Inhibits the synthesis of inflammatory mediators such as IL-1, TNF-a, NF-κB as well as inhibition of
lipoxygenase pathway and scavenging of free radicals.
works as colonic enema
Adverse Effects: Primarily from sulfapyridine breakdown product (Stevens Johnson syndrome)
SAFE PREGNANCY |
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Term
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Definition
does NOT act like aspirin via COX acetylation
Inhibits the synthesis of inflammatory mediators such as IL-1, TNF-a, NF-κB as well as inhibition of
lipoxygenase pathway and scavenging of free radicals.
SAFE PREGNANCY |
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Term
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Definition
does NOT act like aspirin via COX acetylation
Inhibits the synthesis of inflammatory mediators such as IL-1, TNF-a, NF-κB as well as inhibition of
lipoxygenase pathway and scavenging of free radicals.
works in colon
SAFE PREGNANCY |
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Term
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Definition
does NOT act like aspirin via COX acetylation
Inhibits the synthesis of inflammatory mediators such as IL-1, TNF-a, NF-κB as well as inhibition of
lipoxygenase pathway and scavenging of free radicals.
best with slow release pharmacokinetics
SAFE PREGNANCY |
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Term
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Definition
NK1 Antagonists –
blocks the neurokinin receptor for substance P
ANTIEMETIC |
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Term
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Definition
| anti-muscarinic for motion sickness |
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Term
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Definition
mixed antagonist/agonist
D2/5-HT3 Antagonist, M agonist
antiemetic AND prokinetic
Parkinson-like,
acute dystonic reactions, extrapyramidal reactions |
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Term
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Definition
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Term
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Definition
| osmotic laxitive (purgative) |
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Term
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Definition
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Term
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Definition
| softening of feces, act in 1-3 days (low dose osmotic) |
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Term
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Definition
opioid anti-diarrheal (doesnt cross BBB)
BEST IBS + DIARHHEA |
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Term
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Definition
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Term
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Definition
| antimuscarinic anti-diarrheal |
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Term
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Definition
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