Term
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Definition
H2-Receptor Antagonist
Reduces gastric acidity in PUD (NOT H. pylori), GERD, gastritis (take BEFORE meals)
Side Fx: Confusion, Antiandrogenic, potent CYP inhibitor, avoid in preg/nursing |
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Term
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Definition
H2-Receptor Antagonist
Reduces gastric acidity in PUD (NOT H. pylori), GERD, gastritis (take BEFORE meals)
Side Fx: Avoid in preg/nursing |
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Term
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Definition
H2-Receptor Antagonist
Reduces gastric acidity in PUD (NOT H. pylori), GERD, gastritis (take BEFORE meals)
MOST POTENT
Side Fx: Avoid in preg/nursing |
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Term
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Definition
H2-Receptor Antagonist
Reduces gastric acidity in PUD (NOT H. pylori), GERD, gastritis (take BEFORE meals)
GREATER BIOAVAILABILITY
Side Fx: Avoid in preg/nursing |
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Term
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Definition
PPI (irreversible ATPase inhibitor)
Lipophilic weak base, Prodrug
GERD, PUD (moreso DU) (take BEFORE meals)
Side Fx: Diarrhea, HA, Ab pain, ^enteric infection (i.e. C. diff) |
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Term
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Definition
For H. pylori PUD:
PPI BID
Clarithromycin BID
Amoxicillin/Metronidazole BID |
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Term
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Definition
PPI (irreversible ATPase inhibitor)
Lipophilic weak base, Prodrug
GERD, PUD (moreso DU) (take BEFORE meals)
HIGH bioavailability
Side Fx: Diarrhea, HA, Ab pain, ^enteric infection (i.e. C. diff) |
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Term
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Definition
PPI (irreversible ATPase inhibitor)
Lipophilic weak base, Prodrug
GERD, PUD (moreso DU) (take BEFORE meals)
HIGH bioavailability
Side Fx: Diarrhea, HA, Ab pain, ^enteric infection (i.e. C. diff) |
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Term
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Definition
PPI (irreversible ATPase inhibitor)
Lipophilic weak base, Prodrug
GERD, PUD (moreso DU) (take BEFORE meals)
Side Fx: Diarrhea, HA, Ab pain, ^enteric infection (i.e. C. diff) |
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Term
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Definition
PPI (irreversible ATPase inhibitor)
Lipophilic weak base, Prodrug
GERD, PUD (moreso DU) (take BEFORE meals)
LONGEST t1/2
Side Fx: Diarrhea, HA, Ab pain, ^enteric infection (i.e. C. diff) |
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Term
| Magnesium Hydroxide (Mg(OH)2) |
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Definition
Antacid
Weak bases -> React with HCl -> Form salt+H2O
Heal DU (not shown for GU)
Side Fx: Diarrhea |
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Term
| Aluminum Hydroxide (Al(OH)3) |
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Definition
Antacid
Weak bases -> React with HCl -> Form salt+H2O
Heal DU (not shown for GU)
Side Fx: Constipation |
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Term
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Definition
Selective binds ulcer tissue + bile salts, ^PGE
Activated via acid
Heal DU |
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Term
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Definition
Selective binds ulcer tissue, inhibit pepsin, ^PGE, ^mucus
Antimicrobial against H. pylori
+Antibiotics -> GREAT ulcer healing (Pylera) |
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Term
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Definition
PGE1 analog
^mucus, decreased acid
NSAID-induced ulcer PREVENTION
Side Fx: Diarrhea, abortifacient |
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Term
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Definition
D2-receptor Antagonist
^LES tone, ^motility
Treats gastroparesis, GERD, antiemetic
Side Fx: Extrapyramidal symptoms, ^prolactin |
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Term
| Psyllium, Methylcellulose, Polycarbophil |
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Definition
Bulk-forming Laxatives
Indigestible
Absorb water -> Form bulky gel -> ^Peristalsis
Side Fx: Bloating, flatus |
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Term
| Docusate, Glyercin Suppository, Mineral Oil |
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Definition
Stool softeners
^H2O + lipid penetration in stool |
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Term
| Magnesium Hydroxide, Sorbitol, Lactulose |
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Definition
Osmotic Laxatives
^stool liquidity |
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Term
| Magnesium Citrate, Sodium Phosphate |
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Definition
Osmotic Laxatives
RAPID bowel evacuation |
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Term
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Definition
Stimulant Laxatives
Stimulate ENS + ^secretion of fluid/electrolytes
FASTER if given rectally |
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Term
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Definition
Antidiarrheal Agent (Opioid agonist)
Inhibit ACh release
DO NOT give with fever/bloody diarrhea
Side Fx: HIGH DOSE -> CNS |
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Term
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Definition
OTC Antidiarrheal Agent (Opioid agonist)
Inhibit ACh release
DO NOT give with fever/bloody diarrhea |
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Term
| Amitriptyline, Desipramine |
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Definition
Low dose TCAs
Chronic ab pain with IBS |
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Term
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Definition
5-HT3-receptor Antagonist
Inhibit visceral pain sensation in IBS |
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Term
| Sulfasalazine, Olsalazine, Balsalazide, Mesalamine |
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Definition
5-ASAs (Anti-inflammatory)
FIRST LINE for Mild-Moderate IBD
Sulfasalazine -> ^Side Fx |
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Term
| Prednisone, Prednisolone, Hydrocortisone |
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Definition
Glucocorticoids (steroids)
Moderate-Severe IBD
Hydrocortisone may be an enema/foam/suppository prep -> ^local effects |
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Term
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Definition
Controlled-release Glucocorticoid
Rapid FPHM
Treat CD |
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Term
| Azathioprine, 6-Mercaptopurine, Methotrexate |
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Definition
Purine Antimetabolites
Immunosuppressive
Induce/maintain remission in UC/CD (Methotrexate more for CD) |
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Term
| Infliximab, Adalimumab, Certolizumab |
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Definition
Anti-TNF MAbs
Moderate-Severe CD (Infliximab also for UC)
Side Fx: ^Opportunistic infection |
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Term
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Definition
Anti-integrin a4 Mab
Prevent diapedesis -> Decreased inflammation
Moderate-Severe CD
Side Fx: Leukoencephalopathy |
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