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gi drugs
greenwood
17
Pharmacology
Graduate
01/13/2011

Additional Pharmacology Flashcards

 


 

Cards

Term

1. aluminium hydroxide

Definition
Antacid
se- constipation
Calcium antacids taste like chalk.
Term
Bulk Laxatives (fiber)
Saline/Osmotic Laxatives (glycerine,sorbitol)
Irritant or Stimulant Laxatives (bisacodyl, phenolphalein, seena, castor oil)
Stool Sofener (docusates)
Definition
ummm laxatives?
Term
Omeprazole
and other Prazoles
Definition
PPIs
Mech: Permanently disable H/P ATP pump on parietal cells.
Term
misoprostol
Definition
prostglandins- mucous layer protecting agent
Term
sucralfate
Definition

coating agents

 

mech: fills ulcers; protects from acid

Term
helicobacter pylori treatment
Definition

2 antibiotics (clarithromycin, amoxicillin)

and 

1 PPI

Term
bethanecol
Definition
prokinetic
Term

1. metoclopramide

 

2. domperidone

Definition

prokinetic

 

mech: D2 agonist

 

action: stim GI motility and anti emetic (central)

 

SE: tardive dyskinesia + stims prolactin release (leads to gynecomastia)

 

1. can pass BBB more SE

2. no passage thru BBB, less effective

Term

1. tegaserod

 

2. prucalopride

Definition
prokinetic
approved under restricted use- no heart probs, must sign waiver
Term
erythromycin
Definition

prokinetic

 

mech: motilin agonist on muscle and nerves

 

SE diarrhea

 

also antibiotic derp derp

Term
Alvimopan
Definition
post-operative ileus (hospital only)
Term

1. methylnaltrexone

 

2. alvimopan

Definition

μ-opoid antagonist

 

1. constipation - SE flatulence

 

2. post op ileus- 7 day use only (mi risk)

only used in hospital

 

only drug for IBS really

Term
loperamide
Definition

opiod w/ no cns activity

 

DO NOT USE WITH IBD

can cause toxic megacolon

Term

1. glucocorticoids ( budesonide)

 

2. sulfasalazine

Definition

IBD

 

2. maintains IBD remission

prodrug, cleaved by colonic bacteria

5A-salacylic acid derivative 

5(ASA)

 

tx- folate deficiency, reversible male infertility

Term

infliximab

Definition

immunosuppresants for IBD

 

mech: TNF-α inhibitors

Term
alosetron
Definition
5ht3 receptor agonist
female patients with diarrhea predominant IBS
Term

ondansetron

tropisetron

granisteron

palosetron

Definition

anti emetics

 

5-HT3 antagonist (vagal)

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