Term
aluminum hydroxide
magnesium hydroxide
calcium carbonate |
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Definition
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Term
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Definition
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Term
| the "-tidines" drug class |
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Definition
Histamine-2 Receptor Blockers
compete with histamine at H2 receptors of parietal cells-
inhibits gastric acid secretion |
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Term
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Definition
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Term
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Definition
proton pump inhibitors
inhibits proton pump of parietal cells- decreases acid secretion |
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Term
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Definition
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Term
| increases the rate of gastric emptying by an unknown mechanism |
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Definition
| Metoclopramide- promotility agent |
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Term
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Definition
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Term
| a synthetic prostaglandin E1 analog, replaces protective PGs consumed w/ PG- inhibiting therapies |
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Definition
| Misoprostil- prostaglandin |
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Term
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Definition
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Term
| forms a protective barrier in stomach and is a weak acid neutralizer |
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Definition
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Term
bismuth subsalicylate
ranitidine bismuth citrate |
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Definition
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Term
| may have a local gastroprotective effect, stimulates PGs, and suppresses H. pylori |
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Definition
| bismuth subsalicylate or ranitidine bismuth citrate- bismuth prepartation |
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Term
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Definition
hypercalcemia, hypermagnesemia
Mg2+ Hydroxide- diarrhea
Aluminum hydroxide- constipation
Calcium carbonate- constipation |
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Term
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Definition
D/N/V
rare bone marrow suppresion, hepatotoxicity
REDUCE DOSE W/ MODERATE TO SEVERE RENAL IMPAIRMENT! |
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Term
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Definition
confusion, hallucinations, seizures w/ IV
gynecomastia, impotence w/ prolonged or high doses |
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Term
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Definition
D/N/C, HA, dizziness, skin rash
rebound acid hypersecretion (taper or step down to H2RA)
increased fracture risk w/ overuse
increased risk of pneumonia of C. diff diarrhea |
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Term
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Definition
extrapyramidial effects (EPSE)
BLACK BOX WARNING: TARDIVE DYSKINESIA
N/D, restlessness, drowsiness, fatigue |
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Term
| prophylaxis of extrapyramidal effects of metoclopramide |
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Definition
| diphenhydramine (benadryl) |
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Term
| AE of synthetic prostaglandin Misoprostil |
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Definition
CONTRAINDICATED IN PREGNANCY: uterine contraction
D (30-40%)
abdominal pain, nausea, flatulance |
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Term
| how would you minimize diarrhea in pt just put on misoprostil |
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Definition
| start w/ low dose and titrate up |
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Term
AE is constipation
is SAFE in pregnancy
weak acid neutralizer that forms a protective barrier in the stomach
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Definition
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Term
| AE of bismuth preparations |
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Definition
black stool/tongue
may cause salicylate sensitivity |
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Term
| this medication is CI in ppl with herpes zoster (Reye's syndrome) and use with caution in older pts, pts w/ renal failure, children, and influenza |
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Definition
bismuth subsalicylate
ranitidine bismuth citrate
(pepto-bismol) |
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Term
drug intrxn causing chelation of tetracyclines, FQs, and iron
also decreases absorption of drugs that are absorbed at low pHs (ketoconazole, TCs) |
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Definition
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Term
| inhibits CYP450 (causing an increase in serum concentration levels of anti-coagulants, theophylline, phenytoin, etc.) |
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Definition
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Term
| omeprazole inhibits the isoenzyme 2C19 of CYP450 causing what drug intrxns |
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Definition
-decreases clopidogrel's active metabolite levels and antiplatelet activity by up to half (no proof that this worsens CV outcomes though)
-alters medications absorbed at low pH |
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Term
| drug intrxns of promotility agent Metoclopramide |
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Definition
increases risk of HTN with concomitant use of MAOI
increases toxicity of antipsychotics
decreases absorption of many drugs |
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Term
| possible drug intrxn of misoprostil |
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Definition
| may increase effect of oxytoin |
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Term
| drug causing chelation of phenytoin, warfarin, FQs, thyroxine |
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Definition
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Term
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Definition
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Term
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Definition
metoclopramide
omeprazole
ranitidine |
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Term
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Definition
prochlorperazine
ondansetron |
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Term
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Definition
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Term
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Definition
moxifloxacin
loratadine
fluticasone |
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Term
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Definition
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Term
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Definition
EPSE
tardive dykinesia
N/V/fatigue
CI: gi perf, obstruc, hemorrhage
pheochromocytoma, hx of seizures |
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Term
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Definition
N/V/C/HA
increased fracture risk
rebound hypersecretion |
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Term
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Definition
N/V/D
bone marrow suppression
hepatotox |
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Term
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Definition
| EPSE, dystonia, sedation, bone marrow aplasia |
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Term
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Definition
coma
CNS depresssion
Reye's syndrome
<2yrs or <9kg |
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Term
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Definition
| diarrhea and abdominal cramps |
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Term
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Definition
C/D/HA
asthenia
dizziness |
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Term
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Definition
maculopaplar rash w/ mono, N/V/D/HA, dizzy
CI: PCN allergy |
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Term
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Definition
N/V/HA
abdominal pain
CI: use with anti-fungals |
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Term
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Definition
N/V
tendon inflammation
QT prolongation
dizzy |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
nose bleed
runny nose
burning
sneezing
HA |
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Term
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Definition
increase HR and BP
CNS stimulation
stroke |
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Term
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Definition
<6yrs
use of MAO in past 14 days
pt w/ HTN |
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