Shared Flashcard Set

Details

GI drugs
pharm final
38
Health Care
Graduate
05/05/2009

Additional Health Care Flashcards

 


 

Cards

Term
H2RA's
Definition

cimetidine

ranitidine

famotidine

nizatidine

Term
drugs to tx PUD and gerd
Definition

H2RA's

PPI's

Antacids

PPG's

Prokinetic agents

Term
MOA H2RA's
Definition
block H2 receptors to inhibit gastric acid secretions
Term
do pts on H2RA's develop tolerance
Definition
YES!
Term
Cimetidine AE's
Definition

LOTS OF DI's!!!!! all they CYP enzymes!

confusion in elderly

gynecomastia in men

Term
most potent H2RA
Definition
famotidine
Term
PPI's
Definition

Omeprazole

Lansoprazole

Rabeprazole

Pantoprazole

Esomeprazole

Term
PPI's MOA
Definition

bind and irreversibly inhibit H+/K+ ATPASE pump

-> decr acid secretion

Term
which PPI's should be avoided in liver and renal probs
Definition

omeprazole

 

lansoprazole (liver)

Term
effect of which PPI are decr by smoking
Definition
pantoprazole
Term
Anti-Muscarinics
Definition

antispasmotics

 

dicylcomine

glycopyrrolate

Term
Antacids
Definition

MgOH

AlOH

calcium carbonate +simethicon

sodium bicarb

 

Term
Antacids can cause ______ in pts w/ renal dz
Definition
hypermagnesemia (MOM)
Term
which antacid works the quickest
Definition
sodium bicarb (not used much bc of sodium)
Term
prob w/ PPI's tx PUD and GERD?
Definition
pH must be kept at 3.5-4.0 around the clock so reg PRN dosing needed
Term
SE's antacids
Definition

diarrhea/constipation

hypermagnesemia

"milk-alkali sx"

Term
which antacid effect urine pH
Definition

calcium carbonate

 

effects renally excreted drugs

Term
cytoprotective drugs
Definition

Sulcralfate

misoprostol

arthrotec

 

**protect GI mucosa

Term
misoprostol should not be used in these pts
Definition
preggo -> uterine cxns!
Term
Antidiarrheal drugs
Definition

Opiods

bulk-forming agents

others

Term
opiods for diarrhea
Definition

loperamide

paregoric

diphenoxylate + atropine

Term
loperamide is a structural analogue of what drug?
Definition
meperidine
Term
bulk-forming agents
Definition

attapulgite

polycarbophil

Term
other diarrhea drugs
Definition

bismuth subsalicylate

 

***PUD***

Term
Laxatives
Definition

bulk-forming agents

surfactants

contact agents

saline laxatives

Term
bulk-forming laxatives
Definition

methylcellulose

psyllium

bran

Term
bulk-forming laxatives should always be taken w/?
Definition
a full glass of h2o
Term
surfactant laxatives
Definition

docusate + Na, Ca

doxidan

Term
contact agent laxatives
Definition

senna

cascara sagrada

phenolphthalien

biscodyl

cator oil

Term
saline laxatives
Definition

MgOH

Mg sulfate/citrate

Na phosphate

Na bisphosphate

phosphate

Term
misc laxative agents
Definition

glycerine

lactulose

mineral oil

polyethylene glycol

Term
which misc laxative is goof ro pts w/ portal encephalopathy bc it decr ammonia?
Definition
lactulose
Term
which misc laxative agent is good for pts where straining is contraindicated?
Definition
mineral oil
Term
which misc laxative agent impairs abs of oral meds?
Definition

mineral oil

fat sol vits, BCPs and anticoags

Term
anti-emetics for motion sickness
Definition

anti-histamines

anticholinergics

Term
anti-emetics for central cause
Definition

phenothiazine

cannabinoid

metoclopramide

Term
anti-emetics for chemo
Definition

ondansetron

granisetron

dolesetron

Term
drugs that incr gastric motility
Definition
metoclopramide
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