Term
| Gastrin stimulates what cells |
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Definition
1. parietal (HCl & IF)
2. Enterochromaffin-like cells--Histamine-- parietal cells--acid |
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Term
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Definition
| ph below 3, which also stimulates somatostatin prod. |
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Term
| Zollinger Ellison Syndrome |
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Definition
| small gastrinomas- produce lots of acid--test: give gastrin & see no increase in acid= tumor |
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Term
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Definition
| CCK is stimulated by fatty acids & peptides & is related to gastrin chemically |
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Term
| CCK stimulates/relaxes what |
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Definition
CCK stimulates gallbladder contraction, relaxes Sphincter of Oddi, & stimulates enzyme secretion & potentiates bicarbonate secretion caused by secretin.
Potentiations are important in combined effects of hormones |
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Term
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Definition
| CCK Feeds back & inhibits gastric emptying. Fat is the limiting foodstuff. If digestion is proceeding slowly, CCK is increased, feeds back & reduces rate at which food is coming out of stomach into duodenum, allowing complete digestion to occur |
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Term
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Definition
CCK not affected by whole proteins or whole fats
CCK has weak response to acid |
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Term
| Secretin stimulus for release |
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Definition
| reacts strongly to PH under 4.5- often called NATURE's ANTACID |
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Term
| Only hormone released in response to ALL three food stuffs (hydrolyzed fats, amino acids, glucose) |
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Definition
| Gastric Inh Peptide (GIP) [Peptide YY prob stronger inhibitor] |
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Term
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Definition
| Motilin is stimulated by fat & acid in duodenum. Occurs SPONTANEOUSLY during interdigestive periods |
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Term
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Definition
| strong stimulus for insulin release |
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Term
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Definition
| released during fasting, stimulates food intake (orexigenic) & GH release |
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Term
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Definition
| released from intestine by FATS and feedsback to inhibit gastric acid secr. & SUPPRESSES appetite (antiorexigenic). |
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Term
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Definition
| binds guanyly cylclase to up cGMP & open CFTR Cl- secretion [E.coli mimics effect to cause diarrhea). |
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Term
| Half of GI peptide tumors are? |
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Definition
| 50% gastrinomas (up secrete acid) |
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