Term
| Which pharmacokinetic property decreases the least in the elderly? |
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Definition
|
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Term
| Alzheimers disease is related to a decrease in which neurotransmitter? |
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Definition
|
|
Term
| What classes of drugs can worsen alzheimers disease? |
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Definition
Antidepressants
Antiparkinsonian agents
Antipsychotics
antispasmodics
antihistamines
antiemetic-antivertigo |
|
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Term
|
Definition
Tacrine
Usual dosage 10-20 mg bid
capsules
cholinesterase inhibitor
Alzheimers Drug |
|
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Term
|
Definition
Donepezil
5-10 mg at bed time ONCE DAILY
23 mg tablet now approved for moderate to severe
Alzheimers Drug
Tablets, oral solution, disintegrating tablet
cholinesterase inhibitor |
|
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Term
|
Definition
Rivastigmine
1.5 - 6 mg BID
capsule, transdermal patch
cholinesterase inhibitor
Alzheimers Drug |
|
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Term
|
Definition
Galantamine
4-12 mg BID
tablets, ER capsule, oral solution
cholinesterase inhibitor
Alzheimers Drug |
|
|
Term
|
Definition
Memantine
10 mg BID
tablets and oral solution
NMD-receptor antagonist, blocks glutamine effects
Alzheimers Drug |
|
|
Term
| Parkinsons disease is due to a decrease in which neurotransmitter? |
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Definition
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Term
|
Definition
Carbidopa-levodopa
give multiple times a day
Available as tablet, sustained release tablet, oral disintegrating tablet
MOA: levodopa increases dopamine concentration, carbidopa prevents peripheral metabolism of levodopa
Anti-Parkinsonion drug |
|
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Term
|
Definition
Bromocriptine
Available as tablets given BID
MOA: directly stimulates dopamine receptors
Anti-Parkinsonion drug |
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Term
|
Definition
Pramipexole
tablets TID
MOA: directly stimulates dopamine receptors |
|
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Term
|
Definition
Ropinirol
tablets and ER tablets avilable
max 24 mg/d given TID
Anti-Parkinsonion drug |
|
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Term
|
Definition
Apomorphine
0.2-0.6ml SC
must give trimethobenzamide (anti-emetic with the drug)
MOA: directly sitmulates dopamine receptors
Anti-Parkinsonion drug |
|
|
Term
|
Definition
Selegiline
Give BID
Available as tablet, ODT
MOA: Inhibits monomamine oxidase B and increases dopamine and seratonin
Anti-parkinsonian drug |
|
|
Term
|
Definition
Selegiline
Give BID
Available as tablet, ODT
MOA: Inhibits monomamine oxidase B and increases dopamine and seratonin
Anti parkinsonian drug |
|
|
Term
|
Definition
Selegiline
Give BID
Available as tablet, ODT
MOA: Inhibits monomamine oxidase B and increases dopamine and seratonin
Anti parkinsonian drug |
|
|
Term
|
Definition
Selegiline
Give BID
Available as tablet, ODT
MOA: Inhibits monomamine oxidase B and increases dopamine and seratonin
Anti parkinsonian drug |
|
|
Term
|
Definition
Rasagiline
given once daily
tablets avilable
MOA: inhibits monoamine oxidase B increases dopamine and serotonin
Anti-parkinsonian drug |
|
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Term
|
Definition
Entacapone
MUST BE GIVEN WITH EACH DOSE OF LEVODOPA
tablets
MOA: COMT inhibitor, increases dopamine
Anti-parkinsonian drug |
|
|
Term
|
Definition
Tolcapone
Given with levodopa TID
tablets
MOA: COMT inhibitor, increases dopamine
Anti-parkinsonian drug |
|
|
Term
|
Definition
Amantadine
Give BID
Tablets, capsules, syrup
MOA: increase presynaptic release of dopamine; blocks reuptake
Anti-parkinsonian drug |
|
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Term
|
Definition
Benztropine
give PO, IM, IV at bedtime
MOA: blocks acetylcholine, may balance dopamine
Anti-parkinsonian drug |
|
|
Term
|
Definition
Trihexyphenidyl
Give in divided doses up to 5mg/d
tablets, elixir
MOA: blocks ach, may balance dopamine
Anti-parkinsonian drug |
|
|
Term
|
Definition
Carbidopa-entacapone-levodopa
UP to 8 tablets a day
3 dose combinations available
Anti-parkinsonian drug |
|
|
Term
| With parkinson's disease, if you notice suboptimal response after increasing the dose of levodopa you can? |
|
Definition
| Add a dopamine agonist, selegiline or COMT inhibitor |
|
|
Term
| With parkinson's disease, if you notice "on and off" phneomenon you can? |
|
Definition
| use more frequent doses of sustained release levodopa |
|
|
Term
| With parkinson's disease, if you notice acute intermittent hypomobility "off"episodes, you can? |
|
Definition
|
|
Term
| With parkinson's disease if you notice end of dose wearing off you can? |
|
Definition
| give levodopa more frequently or use Sustanined release levodopa. |
|
|
Term
| Dose of levodopa lasts for about? |
|
Definition
|
|
Term
| Apomorphine interacts with |
|
Definition
| ondansetron and Serotonin receptor antagonists leading to severe hypotension |
|
|
Term
| Selegiline interacts with? |
|
Definition
| Sertonergics, SSRis, buspirone, mirtazapine leading to seratonin syndrome |
|
|
Term
| COMT inhibitors interact with |
|
Definition
nonselective MAOI: phenelzine
leading to serotonin syndrome |
|
|
Term
|
Definition
Timolol
eye drop BID for solution, QD for gel
solution
gel forming solution
nonselective beta antagonists
first choice for open angle glaucoma |
|
|
Term
|
Definition
Carteolol
eye drop BID
solution
nonselective beta blocker
glaucoma |
|
|
Term
|
Definition
Levobunolol
eye drop
1-4 times daily
solution
nonselective beta blocker
glaucoma |
|
|
Term
|
Definition
Metipranolol
eye drop
BID
solution
nonselective beta blocker
glaucoma |
|
|
Term
|
Definition
Betaxolol
eye drop
solution BID
Selective beta blocker: less effect on HR and bP
glaucoma |
|
|
Term
|
Definition
Acetazolamide
1-4 times daily
tabelts and ER formulation (1-2 x daily)
do not use with sulfa allergy
Carbonic anhydrase inhibitor |
|
|
Term
| Do not use carbonic anhydrase inhibitors with what allergy? |
|
Definition
| do not use with sulfa allergy |
|
|
Term
|
Definition
Dorzolamide
eye drop solution
TID
do not use with sulfa alergy
Carbonic anhydrase inhibitor |
|
|
Term
|
Definition
Brinzolamide
eye drop solution
TID
do not use with sulfa alergy
Carbonic anhydrase inhibitor |
|
|
Term
|
Definition
Methazolamide
tablets 1-3 times a day
do not use with sulfa alergy
Carbonic anhydrase inhibitor |
|
|
Term
|
Definition
Latanoprost
eye drop solution
QHS
Drug can change color of blue eyes to brown
Prostaglandin analogues
glaucoma |
|
|
Term
|
Definition
Bimatoprost
eye drop solution
QHS
drug can cause darkening of eyelids and lashes
Prostaglandin analogues
glaucoma |
|
|
Term
|
Definition
Travoprost
eye drop solution
QHS
ocular hyperemia frequently occurs
Prostaglandin analogues
glaucoma |
|
|
Term
|
Definition
Unoprostone
eye drop solution
BID
Prostaglandin analogues
glaucoma |
|
|
Term
|
Definition
Brimodidine
eye drop solution
TID
what 15 mins before place soft contacts in the eye
alpha 2 adrenergic agonist
glaucoma |
|
|
Term
|
Definition
Dipivefrin
eye drop solution
BID
prodrug of epinephrine
alpha 2 adrenergic agonist
glaucoma |
|
|
Term
|
Definition
Pilocarpine
eye drop solution and gel
soltuion: 3-4 x daily
gel: 1/2 in gel at bedtime
once weekly dose of Ocuserts available
Cholinergic
glaucoma |
|
|
Term
| Beta adrenergic antagonists help glaucoma by: |
|
Definition
| decreas in aqueous humor formation with slight increase in outflow (Beta selective) |
|
|
Term
| Miotics (cholinergics): pilocarpine help glaucoma by: |
|
Definition
| increase in aqueous humor outflow |
|
|
Term
| Carbonic anhydrase inhibitors help glaucoma by: |
|
Definition
| decrease in aqueous humor formation |
|
|
Term
| Prostaglandin analogs help glaucoma by: |
|
Definition
| increased uveoscleral outflow without effect on aqeous humor formation |
|
|
Term
| Alpha 2-adrenergic agonists help glaucoma by: |
|
Definition
| decrease in aqueous humor formation |
|
|
Term
| other alpha adrenergic agonists (epinephrine, dipivefrin)help glaucoma by? |
|
Definition
| increase in aqueous humor outflow |
|
|
Term
|
Definition
Terazosin
alpha-adrenergic receptor blocker
for overflow urinary incontinence
tablets |
|
|
Term
|
Definition
Doxazosin
alpha-adrenergic receptor blocker
for overflow urinary incontinence
tablets |
|
|
Term
|
Definition
doxazosin
alpha-adrenergic receptor blocker
for overflow urinary incontinence
extended release tablets |
|
|
Term
|
Definition
prazosin
alpha-adrenergic receptor blocker
for overflow urinary incontinence
capsules |
|
|
Term
|
Definition
Tamsulosin
alpha-adrenergic receptor blocker
for overflow urinary incontinence
tablets |
|
|
Term
|
Definition
Alfuzosin
alpha-adrenergic receptor blocker
for overflow urinary incontinence
extended release tablets |
|
|
Term
|
Definition
Finasteride
5-alpha reductase inhibitor
for over flow urinary incontinence
tablets |
|
|
Term
|
Definition
Dutasteride
5-alpha reductase inhibitor
for over flow urinary incontinence
gel capsules |
|
|
Term
|
Definition
Oxybutynin
anticholinergic
for urge urinary incontinence tablets and syrup |
|
|
Term
|
Definition
Oxybutynin
anticholinergic
for urge urinary incontinence
extended release tablets
max 30 mg/d |
|
|
Term
|
Definition
Oxybutynin
anticholinergic
for urge urinary incontinence
transdermal patch
change every 3 days |
|
|
Term
|
Definition
Oxybutynin
anticholinergic
for urge urinary incontinence
transdermal gel once daily |
|
|
Term
|
Definition
Tolterodine
anticholinergic
for urge urinary incontinence
immediate and extended release capsules |
|
|
Term
|
Definition
Trospium
anticholinergic
for urge urinary incontinence
immediate release tablets |
|
|
Term
|
Definition
Trospium
anticholinergic
for urge urinary incontinence
extended release capsules |
|
|
Term
|
Definition
Darifenacin
anticholinergic
for urge urinary incontinence
extended release max 15 mg/d |
|
|
Term
|
Definition
Solifenacin
anticholinergic
for urge urinary incontinence
tablets |
|
|
Term
|
Definition
Fesoterodine
anticholinergic
for urge urinary incontinence
extended release tablets |
|
|
