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Geriatrics
PA CLin Med
114
Health Care
Graduate
03/02/2010

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Term
gerontologist vs geriatrician
Definition
gerontologist: sociology
geriatrician: certified practitioner
Term
increased life expectancy is mostly due to:
Definition
improved infant mortality rate
Term
philosophy of geriatric care revolves around:
Definition
increasing/maintaining independance
Term
ageism:
Definition
unfair judging of elderly adults
Term
capacity for cell division, growth, and function is lost over time ultimately leading to death:
Definition
senescence
Term
microscopic changes in aging skin:5
Definition
1. epidermal thining
2. elastic fiber degeneration
3. thickening of collagen
4. reduced sebaceous and sweat glands
5. diminished vascularity
Term
changes in aging heart:
Definition
1. diminished cardiac responsiveness to B-adrenergic stimulation
2.
Term
creatinine clearance declines at a rate of:
Definition
10ml per decase
Term
by what age do many adults have osteoarthritic changes?
Definition
40
Term
what osteoarthritic changes are visible on xray
Definition
cervical spine
Term
changes in the nervous system with aging:
Definition
1. decrease in peripheral vibratory sensation
2. decrease in sweat production
3. slower processing
4. small decrease in brain mass
Term
most comon age related vision eye problem
Definition
presbyopia
Term
presbycusis
Definition
age related, high frequency sensorineural hearing loss
Term
acute change in mental status w attn deficit accompanied by disorganized thinking or a change in alertness
Definition
delirium
Term
hypoactive delirium must be differentiated from:
Definition
depression
Term
3 types of deliriium:
Definition
hyperactive hypoactive and mixed
Term
"acute brain failure"
Definition
delirium
Term
considered the cornerstone of delirium pathogenesis
Definition
stress
Term
the main stress induced modification of brain neurotransmitters:
Definition
cholinergic defficiency and dopaminergic excess
Term
delirium risk factors:
Definition
1. drugs
2. lytes abnormal
3. infection
4. urinary retention/fecal impaction
5. cardiac issues
6. reduced sensory input
Term
meds play a very important role in the development of delirium as a predisposing and precipitating factor:
Definition
anticholinergic meds: (diphenhydramine, oxybutynin)
Term
assessment for delirium requires:
Definition
1. face to face interview w pts to identify the presence of emergent situations such as hypoxia, hypotension, or sepsis
2. extensive hx to investigagte causes
Term
delirium tx:
Definition
1. tx underlying cause
2. low dose anti-psychotic
3. benzodiazepines for etoh or sedative withdrawls
Term
when is imaging indicated for delirium?
Definition
only when positive findings present during hx, physical exam or chart review
Term
2 types of interactive therapies to prevent delirium from reoccuring:
Definition
1. tx underlying causes; dehydration, infection, anti-cholinergic meds
2. supportive pharmacologic & nonpharmacologic therapy
Term
first choice of depression meds:
Definition
SSRIs
Term
anti-depression med: used less frequently due to anti-cholinergic effects:
Definition
tricyclics
Term
anti-depression med: best used under direction of the psychiatrist
Definition
MAOI
Term
neurotransmitters implicated in the pathophysiolofy of delirium:
Definition
cholinergic deficiency & dopamine excess
Term
meds that are risk factors for delirium:5
Definition
1. benzodiazepines
2. anti-depressants (amytriptyline, imipramine)
3. anti-cholinergics (diphenhydramine and oxybutynin)
4. anti-convulsants
5. H2 blockers
Term
2 meds to treat delirium:
Definition
1. low dose antipsychotic (haloperidol)
2. Delirium from ETOH withdrawl benzodiazepines
Term
3 somatic complaints of depression:
Definition
1. fatigue
2. abd pain
3. HA
Term
pseudodemintia:
Definition
common presentation of depression in the elderly
Term
medications that can cause depression in the elderly:3
Definition
digitalis, propanolol, and benzodiazepines
Term
which labs should be checked when evaluating a patient for depression:
Definition
CBC
Chemistry
T4 & TSH
VB12
Folate
Term
anti-depressant that should not be used in the elderly:
Definition
AMITRYPTALINE due to sedation and anti-cholinergic effects
Term
which med for first line tx of depression:
Definition
SSRIs
Term
SE of SSRIs:
Definition
insomnia... dose in the mornings to avoivd insomnia & GI distress
Term
SE of TCAs:
Definition
anticholinergic effects (drowsiness, constipation, blurred vision, dry mouth, orthostatic hypotension
Term
which TCA is considered first line in the elderly?
Definition
Nortrotyline at bedtime- has less anticholinergic effects
Term
indications for nortryptyline:
Definition
depression assoc w chronic pain, insomnia, psychomotor agitation
Term
major consideration for prescribing MAOIs:
Definition
dietary restriction - low tyramine foods due to risk of HTN crisis or orthostatic hypotension
Term
antidepressant that is also used as an appetite stimulant:
Definition
Mirtazipine
Term
premonitory falls:
Definition
falls that occur as a prodrome to an illness
Term
apathetic thyrotoxicosis:
Definition
tiredness and slowing down caused by HYPERthyroidism
Term
hypothyroidism in the elderly presents as:
Definition
agitation and confusion
Term
screening tool used to asses ADLs:
Definition
PSMS - physical self maintenance scale
Term
screening tool used to asses instrumental ADLs:
Definition
FAQ - functional activities questionaire
Term
age group where orthostatic hypotension is common:
Definition
over 85
Term
2 respiratory findings that dont necessarily indicate a pathology:
Definition
1. decreased breath sounds
2. dry basilar crackles
Term
which heart sound always indicates CHF
Definition
S3
Term
3 processes indicated in the cause of dementia:
Definition
1. B-amyloid plaques
2. Tau proteins metabolism and neurofiber tangles
3. depletion of NTs, particularly in the cholinergic p-ways
Term
6 RF for AD:
Definition
1. FHx
2. Down's syndrome
3. head trauma
4. CVD
5. HRT
6. Age
Term
5 factors that may decrease risk for AD:
Definition
1. higher education
2. leisure activities
3. exercise
4. statins
5. maintaining lab values (Glu, BP, etc.)
Term
conditions and defects that may reflect intermediate and possibly transient states between normal aging and dementia
Definition
mild cognitive impairment
Term
5 features of mild cognitive impairment:
Definition
1. memory loss
2. objective deficit in a cognitive domain
3. no impairment in ADLs
4. no dementia
5. no delirium
Term
4 conditions of reversible dementia:
Definition
1. hypothyroidism
2. B12 def
3. neurosyphilis
4. SDH
Term
most common etiology of dementia:
Definition
AD
Term
4 cognitive declines of dementia:
Definition
1. memory
2. language
3. visuospacial
4. executive function
Term
what is required for definative dx of AD?
Definition
brain Bx
Term
requirements for probable dx of AD:
Definition
deficits in memory and absence of comorbidities that would explain sx. present >6mo, slow onset
Term
Lewy Body dementia:
Definition
fluctuating cognitive deficits, parkinsonian signs, attn deficits and visual halucinations
Term
when does dementia from parkinson's occur?
Definition
late in the dz
Term
disinhibition, apathy, ececutive dysfunction:
Definition
fronto-temporal dementia
Term
describe primary progressive aphasia:
Definition
progressive aphasia, hand/motor abnormalities, resembles frontal/prefrontal CVA
Term
triad: urinary incontenance, dementia, apraxic gait:
Definition
normal pressure hydrocephalus; pressures can be decreased with shunt
Term
chorea, progressive cognitive decline, behavioral/psych problems:
Definition
Huntington's dz
Term
etiology of Creutzfeld-Jakob dz:
Definition
prion
Term
MMSE score for mild dementia:
Definition
>17
Term
MMSE score for moderate dementia:
Definition
11-17
Term
MMSE score for severe dementia:
Definition
<10
Term
dull flat facies and cogwheel rigidity
Definition
parkinson's
Term
2 classes of drugs approved for dementia tx:
Definition
1. cholinesterase inhibitors
2. NMDA receptor antagonist (memantine)
Term
2 common types of advanced directives:
Definition
1. appoint surrogate
2. living will
Term
elderly patients account for what portion of flu deaths?
Definition
3/4
Term
how does chantix work?
Definition
blocks nicotine receptors; reduces withdrawl and no pleasure from smoking
Term
why do the elderly have increased sensativity to etoh?
Definition
smaller vol of distribution and decreased liver fxn
Term
med for alcoholism that is contraindicated in the elderly:
Definition
antabuse: hypotension SE
Term
what are the first 2 choices in BP medications:
Definition
1. HCTZ
2. ACE/ARB
Term
LDL goal for heart dz pt:
Definition
<70
Term
are statins useful in elderly?
Definition
yes
Term
quantitative dx for osteoporosis:
Definition
>2.5 SD below the young adult peak for bone density
Term
distribution of meds is altered in the elderly due to:
Definition
decreased lean to fat ration and total body water
Term
medications that are affected by decreased distribution in the elderly:
Definition
digoxin and lithium
Term
meds that are affected by increased fat content (vol dist.
Definition
psycoactive medications (valium increases concentration)
Term
phase I rxn in liver metabolism: increased or decreased in elderly?
Definition
decreased CYP450; affects diazapam
Term
Phase II rxns in elderly: increased/decreased?
Definition
do not diminish with age;
Term
loarzapam: phase I or II rxns?
Definition
II
Term
4 meds to consider renal fxn:
Definition
1. FQs
2. AGs
3. Vanco
4. Cephs
Term
why should caution be used in prescribing NSAIDs to the elderly?
Definition
increased risk for gastritis and GI bleeds
Term
tylenol doses should not exceed:
Definition
3.2g/day
Term
diabetic meds in elderly run the risk of:
Definition
hypoglycemia
Term
which diabetic med in particular should be avoided?
Definition
glyburide
Term
when is metformin contraindicated?
Definition
circulatory failure or renal insufficiency
Term
first line HTN med and dose:
Definition
HCTZ 12.5mg/day max dose 25mg/d
Term
which CCB for HTN should be avoided?
Definition
nifedipine
Term
SE of CCBs:
Definition
peripheral edema and constipation
Term
which B-blockers are to be used if no other choice?
Definition
atenolol or metropolol NOT propanolol
Term
what are considerations for anti-psychotic agents:
Definition
pick ones that have low anticholinergic side effects least sedating
Term
what is the DOC for antipsychotics? dose?
Definition
Risperidal <2mg/d
Term
which antipsychotic meds should be avoided?
Definition
haldol and mellaril
Term
prefered H2 antagonists:
Definition
zantac & pepcid
Term
H2 antagonists that shoudl be avoided:
Definition
tagamet; multiple Rx interactions and 70% renally eliminated
Term
describe the get up and go test:
Definition
rise from a chair and walk 10ft return to the chair and sit most elderly within 11-20s, >14s = increased risk for falls, >20 needs further eval
Term
gait disorders considered low sensorimotor level:
Definition
peripheral sensory
peripheral motor
Term
gait d/o included in middle sensorimotor level:
Definition
1. spacticity
2. parkinsonism
3. cerebellar ataxia
Term
gait d/o considered high sensorimotor level:
Definition
cautious gate and frontal related gait d/o
Term
class of medications that are implicated in increasing the risk for falls>
Definition
1. benxodiazepines
2. Antidepressives
3. antipsychotics
Term
wide based gate w increased trunk sway & irregular stepping:
Definition
cerebellar ataxia
Term
use of __ or more meds is a RF for dizziness:
Definition
>3
Term
syncope that occurs in any position and has <5second warning, faint pulse, flaccid tone
Definition
syncope caused by arrhythmia
Term
syncope with seconds to minutes of warning and precipitate nausea, sweating, visual changes:
Definition
vasovagal syncope
Term
syncope: no warning, rigid tone, rapid pulse, elevated BP, tonic eye deviation:
Definition
syncope due to seizure
Term
recommendations for post prandial syncope:
Definition
1. avoid Etoh
2. avoid high carb meals
3. remain recumbent after meals
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