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Genetics
Mendel
47
Biology
Undergraduate 1
10/23/2008

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Term
Heterozygote advantage
Definition
Carriers of a disease (ie sickle cell anemia) are resistant to another condition (malaria); more likely to survive and have babies.
Term
Cystic fibrosis: recessive or dominant?
Definition
Recessive trait.
Term
autosome
Definition
non sex chromosome; at least two of every autosome is required for survival
Term
Non-disjunction
Definition
Failure of chromosomes or sister chromatids to separate in anaphase; leads to an abnormal number of chromosomes, or aneuploidy
Term
Aneuploidy
Definition
Term
Monosomy
Definition
One less chromosome
Term
Trisomy
Definition
One extra chromosome
Term
Linked
Definition
Physically close together on the same chromosome; tend to be inherited together
Term
Unlinked
Definition
Term
SNP
Definition
single nucleotide polymorphism, change that happened in ancestry. 1% of the population has it. is one nucleotide different than another.
Term
STR
Definition
short tandem repeats. used for MODERN DNA fingerprinting
Term
PCR amplification
Definition
polymerase chain reaction. uses PRIMERS to double the DNA each cycle.
Term
pro's and con's of genetic engineering
Definition
Pros: pest resistance, herbicide resistance, farm animals can produce more milk, nutritious foods, waste clean-up, drugs

Cons: can harm environment because there's no diversity. weeds can become resistant to herbicides, may be harmful to people ie chicken engineering
Term
without a 3' OH, the DNA strand...
Definition
can't be extended by polymerase in replication
Term
DNA technology began by watching..
Definition
bacteria have sex. IE
1) Transformation 2)Transduction 3) Conjugation
Term
Restriction Enzymes
Definition
DNA-cutting enzymes found in bacteria (and harvested from them for use). They cut DNA at specific sequences.
Term
RFLP's
Definition
restriction fragment length polymorphisms. technique in which organisms may be differentiated- DNA fingerprinting (old version). If two organisms differ in the distance between sites of cleavage of a particular restriction endonuclease, the length of the fragments produced will differ when the DNA is digested with a restriction enzyme.
Term
genetic engineering
Definition
the process of moving DNA from one organism to another
Term
natural selection
Definition
the different reproduction of gametes comes from factors in the environment, and leads to evolutionary change through time
Term
steps to natural selection 1-5
Definition
1) individuals vary in many traits
2) variation often passed to offspring
3) resources are limited, so not all offspring survive
4)individuals are more likely to survive with better genes
5) over time, more favorable alleles become common instead of less favorable
Term
bacteria evolve much faster than eukaryotes because
Definition
-20 minute generation time
-population is huge with lots of genetic diversity
- can evolve quickly by getting genes with HORIZONTAL TRANSFER
-plasmids with multiple drug resistance
-antibiotics make bacteria resistant to them
Term
Forces that alter the allele frequencies of a population
Definition
1) Mutation
2) Migration
3) Genetic Drift
4) Non-Random mating
5) Selection
Term
Mutation
Definition
any change in the nucleotide sequence of DNA. Ultimate source of new variation.
Term
Migration
Definition
movement of individuals from one population to another. from a continent to an island. gene flow.
Term
Genetic Drift
Definition
occurs in a small population. is the random loss of alleles.
Term
Non-random mating
Definition
inbreeding
Term
selection
Definition
1)natural-environment selects for adapted characteristics
2) artificial- human
Term
Genetic diversity is important because
Definition
it provides the raw material for natural selection
Term
Stabilizing selection
Definition
eliminate both extreme phenotypes, so intermediate has advantage. ie, birthweight.
Term
Disruptive selection
Definition
extreme phenotypes survive at the expense of intermediate forms. (very big and very small beaked birds survive because they can eat the kinds of nuts)
Term
Directional selection
Definition
an extreme phenotype becomes more prevalent in a population
Term
where does evidence for evolution come from?
Definition
comparative anatomy, comparative physiology, comparative embryology, molecular biology, paleontology, biogreography
Term
Hardy-Weinberg Equilibrium
Definition
is a highly unlikely situation in which the allele frequencies do not change from one generation to the next. evolution does not occur.
Term
biological species concept
Definition
"species are groups of actually or potentially interbreeding natural populations, which are reproductively isolated from other such groups.
Term
micro-evolution
Definition
changes in allele frequency
Term
speciation occurs when..
Definition
there are changes to reproductive barriers
Term
reproductive isolating mechanisms
Definition
are barriers that prevent individuals of different species from interbreeding
Term
evolution
Definition
changes in an organism's traits over time
Term
ecology
Definition
how organisms live in their environment
Term
adaptation
Definition
improvement that is due to natural selection
Term
pre-zygotic isolating mechanisms
Definition
1)geographic isolation
2) ecological isolation (tree/base of tree)
3)Temporal isolation (species reproduce in different seasons/times of the day)
4)behavioral isolation (a bird sings better than another)
5)mechanical isolation (structural differences)
6) prevention of gamete fusion
Term
taxonomy
Definition
branch of biology that identifies and names organisms. Domain, Kingdom, Phylum, Class, Order, Family, Genus, species
Term
post-zygotic isolating mechanisms
Definition
1) Hybrid embryos do not develop properly
2) Hybrid adults are sterile/infertile
Term
How might instantaneous isolation occur?
Definition
Polyploidy- more than two homologous sets of chromosomes, due to a failure of meiosis and separated chromosomes.
Term
problems with the biological species concept?
Definition
works well for animals but not for plants, how can you apply it to populations that do not naturally occur in nature together,
Term
adaptive radiation
Definition
change in the environment causes poorly suited organisms to go extinct (dinosaurs), and other species flourish
Term
phylogeny
Definition
model that shows an evolutionary change and its relationship to other species
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