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Genetics Basics Experiments
the experiments of Griffith, Avery & Macleod, Hershey & Chase, Menelson& Stahl, and Taylor, Woods, & Hughes.
5
Biology
Undergraduate 2
12/18/2025

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Term
Griffith: exp, resp, hyp, and results
Definition
Exp: Type of bacterial mixture injected into mice
Resp: If the mousing died (transformation occurred)
Hyp: A transforming principle in heat-killed virulent transformed avirulent to virulent.
Results: Avirulent=lives, virulent=dies, heat killed virulent=lives, heat killed virulent+avirulent=dies
Term
Avery & McLeod: exp, resp, hyp, and results
Definition
Exp: Type of molecule (protein, RNA, DNA) functioning after enzyme treatment
Resp: whether or not an avirulent was able to be transformed into virulent by the treated heat killed virulent
Hyp: A specific molecule is heat killed virulents are responsible for the genetic transformation of avirulents
Results: Heat kill virulent couldn't transform avirulents into virulent when DNA was destroyed.
Term
Hershey & Chase: exp, resp, hyp, and results
Definition
Exp: Which compound (protein or DNA) is labeled
Resp: Where the isotope is detected following the bacteriophage's attack of a cell
Hyp: DNA, not proteins, carry genetic info
Results:
-when protein labeled: not found in cell, found in phage
-when DNA labeled: found in cell, not found in phage
Term
Meselson & Stahl: exp, resp, hyp, and results
Definition
Exp: heavy and regular nitrogen isotopes
Resp: Density of the extracted DNA in a gradient
Hyp: DNA replication follows a semi-conservative model
Results:
After 1st replication: only one hybrid (both isotopes) band
After 2nd replication: one hybrid band and one light-isotope-only band
Term
Taylor, Woods, & Hughes: exp, resp, hyp, and results
Definition
Exp: number of sell divisions
Resp: Pattern and location of 13H isotope on chromosome
Hyp: DNA replication follows a semi-conservative model
Results:
After 1st replication: both have isotope
After 2nd replication: only one sister chromatid in a homologous chromosome has the isotope.
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