Term
|
Definition
t(8;14)
80% of cases
Translocation of c-MYC close to IgH gene (V region) |
|
|
Term
|
Definition
t(14;18)
~100%
BCL2-IgH affected |
|
|
Term
|
Definition
|
|
Term
|
Definition
Chronic myelogenous leukemia
t(9;22) Philadelphia chromosome
90-95%
BRC-ABL (can be blocked by Gleevec/Imatinib) |
|
|
Term
|
Definition
Acute lymphocytic leukemia
t(12;21)
Hyperploidy
~25%
CBF alpha and ETV 6 |
|
|
Term
|
Definition
Acute myeloid leukemia
AML (M2): t(8;21) CBF
AML (M4): Inv(16) |
|
|
Term
| Acute promyelocytic leukemia |
|
Definition
(AML-M3) t(15;17)
~95%
RARA-PML
good prognosis |
|
|
Term
|
Definition
Chronic lymphocytic leukemia
trisomy 12
del(17p) --> (p53 affected) |
|
|
Term
| Chronic myeloid disorders |
|
Definition
JAK2 V617 mutations
pv: 95-100% |
|
|
Term
|
Definition
| NOTCH 1 mutation, gain of function |
|
|
Term
|
Definition
M1P1 alpha
t(4;14) more aggresive
del(13), del(17) better prognosis |
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|
