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Genes and Genetic Diseases
Section A
36
Health Care
Graduate
06/06/2013

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Term
Transcript the following:
TAT GGG CCC ATA TTA CAA ATC
Definition
AUA CCC GGG UAU AAU GUU UAG
Term
Translate the following:
AUA CCC GGG UAU AAU GUU UAG
Definition
start proline glyc tyro aspar valine stop
Term
Interphase
Definition
Consists of G1, S, and G2
Term
G1 phase
Definition
Involves cell growth and preparation of DNA replication
Term
S phase
Definition
DNA synthesis occurs during this phase
Term
G2 phase
Definition
Condensation of chromatin into chromosomes occurs
Term
M phase (Mitosis)
Definition
Cell divides into two daughter cells containing diploid number of chromosomes
Term
H2A, H2B, H3 and H4
Definition
Core histones
Term
Nucleosome
Definition
DNA wound around histone complexes 1.8 times
Term
Chromatin
Definition
A chain of nucleosomes held close together by H1 like "beads-on-a-string"
Term
Euchromatin
Definition
Chromatin regions undergoing gene expression that are more extended
Term
Heterochromatin
Definition
Chromatin regions with genes that are "quiet" and are more condensed
Term
Acetyl groups
Definition
The addition of these groups to histone tails alters the chromatin structure, creates separation, and increases accessibility for transcription factors and, therefore, gene expression
Term
Methyl groups
Definition
Adding these groups to histone tail make the chromatin region less accessible to transcription factors
Term
Which of the following statements is NOT true?
a. During the S phase, the centrosome replicates just as the chromosome material is replicated.
b. Centrosomes are composed of one centriole.
c. Cytokinesis is a process of cytoplasmic cleavage that completes the M phase and results in the formation of two daughter cells.
d. The mechanism of the mitotic spindle is responsible for orderly separation of chromosomes.
Definition
B. Centrosomes are composed of TWO centrioles
Term
The chemical, paclitaxel, binds to microtubules and causes disruption of the mitotic spindle. Which of the following cell types would be most affected by paclitaxel?
a. Bone marrow stem cells
b. Central nervous system neurons
c. Mature red blood cells
d. Outer layer of skin epithelial cells
Definition
A. Paclitaxel interferes with normal mitosis. To be affected by an antimitotic drug, a cell must either be capable of cell division or undergo relatively rapid cell division. Bone marrow stem cells are engaged in constant cell division to replenish the cells which originate from the bone marrow.
Term
Which of the following statements is NOT true regarding human mitosis and meiosis?
a. Mitosis involves one cell division resulting in two cells with the diploid number of chromosomes
b. Meiosis is necessary to produce the gametes (i.e., egg and sperm), consisting of the haploid number of chromosomes.
18
c. Male and female germ cells begin the first meiotic division during fetal growth and complete the second cell division at sexual maturation.
d. In mitosis, all of the 46 chromosomes line up randomly at the mitotic plate whereas in meiosis, all 23 pairs of chromosomes are paired at the equator of the spindle.
Definition
C. Male germ cells begin meiotic activity at pubery. Female germ cells begin the first meiotic division during fetal growth and complete the second cell division when the egg is released from the avary, or ovulated, 10 to 50 years later.
Term
Occurs when the homologous chromosomes have lined up on the meiotic equator
Definition
Crossing over (genetic recombination)
Term
The breaking and rejoining of DNA strands to form new molecules of DNA encoding a novel set of genetic information
Definition
Crossing over (genetic recombination)
Term
Chromosome pairs of approximately the same length, centromere position, and staining pattern, with genes for the same characteristics at corresponding loci
Definition
Homologous chromosomes
Term
Homologs or homologues
Definition
Homologous chromosomes
Term
Any chromosome not considered as a sex chromosome, or is not involved in sex determination
Definition
Autosomal chromosomes
Term
There are 22 pairs of these chromosomes
Definition
Autosomal chromosomes
Term
X and Y chromosomes
Definition
Sex chromosomes
Term
Referred to as a reductional division
Definition
Meiosis I
Term
The end result is production of four haploid cells (23 chromosomes)
Definition
Meiosis II
Term
At the end of this division, each daughter cell now has half the number of chromosomes but each chromosome consists of a pair of chromatids
Definition
Meiosis I
Term
Can produce a mosaic individual
Definition
Mitotic nondisjunction
Term
Occurs in humans in the form of triploidy (69 chromosomes) or tetraploidy (92 )chromosomes)
Definition
Polyploidy
Term
Aneuploid is the result of?
Definition
Meiotic nondisjunction
Term
Two non-homologous chromosomes break and exchange fragments with no loss or gain in genetic material
Definition
Reciprocal translocation
Term
A zygote having trisomy is the result of?
Definition
Meiotic nondisjunction
Term
Following this event, meiosis can produce gametes with a “balanced” genetic make-up or an “unbalanced” genetic combination, the later resulting in gametes with duplication and deletion of genetic material
Definition
Reciprocal translocation
Term
Results in the production of gametes having a single or extra chromosome
Definition
Meiotic nondisjunction
Term
This event can occurs during the initial stage of meiosis, when the homologous chromosomes have lined up on the meiotic equator and results in duplication of a gene (s) on one homologous pair and a deletion of the same gene (s) on the other
Definition
Uneven crossing over
Term
A zygote having monosomy is the result of?
Definition
Mitotic nondisjunction
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