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General Psychopathology
Mood, Eating, Substance Use, and Somatoform disorders, Schizophrenia
127
Psychology
Graduate
03/16/2011

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Term
MDD
Definition
5+ symptoms and depressed mood or loss of interest/pleasure
significant distress or impairment
2 weeks or more
represents decline
not accounted for by gmc/bereavement
weight loss/gain, insomnia/hypersomnia, psychomotor agitation/retardation, fatique, guilt, etc
Term
MDE
Definition
reference to only an episode
Term
MDD general issues
Definition
suicide assessment
somatization of symptoms
personal relativity of normal/decline
rational reaction to situation?
distinguishing from grief
Term
Grief & Depression
Definition
most severe with loss of spouse
50% of pop qualify for MDE following death
severity and longevity determine if grief can be coded as MDD: +2 months after death
risk factors for progression: previous MDE, poor coping skills, limited support network
Term
Dysthymia
Definition
lower level depression for 2+ years
Term
Seasonal Affective Disorder
Definition
Not currently a DSM diagnosis, just a specifier
Term
MDD Severity
Definition
Mild: symptoms barely meet criteria, little distress, no suicidal ideation
Moderate
Severe: # of symptoms exceed minimum, marked impairment
Term
MDD Psychotic Features
Definition
Psychotic features: automatically severe
Mood congruent: consistent with depressed mood
Mood incongruent: not consistent with mood or are more bizarre (very rare)
Term
MDD Specifiers of Most Recent Episode
Definition
Atypical: reactive, higher weight and eating, excessive sleep
Melancholic: somatic, guilt, lack of appetite, weight loss, typically worse in morning and wake up early
Catatonic: rare
Postpartum Onset

Course:
Single episode/recurrent/chronic
With or without full interepisode recovery
With seasonal pattern (SAD)
Term
MDD & Anxiety
Definition
Almost all pts are anxious but not all anxious pts are depressed
Anhedonia, slowing of motor & cognitive function, & feeling "keyed up"-- most common
"Pure" anxiety sx: apprehension, tension, trembling, excessive worry, nightmares
"Pure" depression sx: helplessness, depressed mood, loss of interest, loss of pleasure, suicidal ideation, diminished libido, rumination
Depression= loss of interest, less activity
Anxiety= increased unfruitful activity
Term
MDD Heritability
Definition
Related to increased risk for anxiety disorders
*Serotonin transporter gene:
short-short: susceptible w/ stress, decreased serotonin expression, (diathesis-stress model)
long-long: protected, increased serotonin expression
Term
MDD NTs
Definition
Low SE= less regulation of NE & DA
Low NE= less activity
Low DA= less pleasure
Term
MDD, Endocrine System, & Sunlight
Definition
Endocrine sytstem: increased cortisol, DST test bc DXM suppresses cortisol-indicates over-responsiveness of adrenal gland
Sunlight: melatonin suppresses SE, excessive daytime melatonin causes depressed affect, exposure to sunlight suppresses melatonin production (moreso for SAD)
Term
MDD Behavioral Etiology
Definition
Lewinsohn- depression is related to a decrease in reinforcement and/or an increase in punishment
Term
MDD Cognitive Etiology
Definition
Learned helplessness theory: attribution style to life events related to vulnerability to depression, no perceived control, common with high abuse and low SES situations), internal (thoughts), stable(over period of time), and global(far-reaching)
Negative cognitive styles (Beck):
cognitive errors- distorted thinking that leads to depressed mood
depressive cognitive triad- negative views about self, world, and future
Schemas- enduring negative core belief about some aspect of life which usually form at a young age
Term
Cognitive Errors
Definition
all-or-nothing thinking
mental filter: over-emphasizing negatives and discounting positives
taking feelings too seriously (as reality)
generalized "should"- should've dones
self-blame
jumping to conclusions: mind-reading, fortune telling
Term
MDD Cognitive Behavioral Tx
Definition
Beck
work on relationship btw thoughts, feelings, and behaviors
10-20 sessions, present-focused
homework given: monitoring thoughts, challenging beliefs, hypothesis testing, tracking symptoms
Eval: most widely studied tx, very effective/ over-simplistic, ignores past
Term
MDD Interpersonal (IPT) Tx
Definition
Klerman
15-20 sessions, present-focused
identify main interpersonal conflicts: interpersonal role dispute, loss of relationship, acquisition of new relationship/roles, deficits in social skills
identify stage: negotiation, impasse, resolution
better for people whose relationships are contributing to depression
Term
MDD Meds
Definition
MAOIs: older, side effects, diet restrictions, good for depression w/ atypical features
Tricyclics: inhibits reuptake of monoamines, narrow therapeutic window, good for depression w/ insomnia & weight loss
SSRIs: also effective for anxiety, take several weeks to work, weight gain, loss of libido, sleep disturbances, possible increase in suicidal ideation bc of gain in energy
Term
Bipolar Disorder General Features
Definition
can presently meet criteria for:
major depressive, manic, hypomanic, or mixed episode
requires at least one manic/hypomanic episode in lifetime
not mood swings
not 2/2 to psychostimulant
Term
Manic Episode General Features
Definition
1+ week or hospitalized before 1 week
abnormal mood: high, irritable, or expansive
main features (3+):
inflated self-esteem, high energy, low sleep, racing thoughts, pressured speech, impulsivity, poor judgement
*hypomanic episode assoc with less time (3-4 days), less sx, less psychosis
*mixed episode fulfill criteria for both MDE and manic episode nearly every day for at least 1 week.
Term
Bipolar Disorder Specifiers
Definition
Severity: mild, moderate, severe
severe with/without psychotic features
Most recent episode specifiers:
with catatonic features
with postpartum onset
course of recurrent episodes:
with or without full interepisode recovery
with rapid cycling: in 1 yr at least 4 episodes of MD, Mania, Mixed, or Hypomania
Term
Bipolar I
Definition
at least one manic episode in lifetime
typically more time spent in MDE than manic
most common is alternation of MDE and manic episodes
Term
Bipolar Disorder Addtl Features
Definition
mania usually experienced as pleasurable, desirable, and productive (to a point)
medication compliance problem
hypomanic can progress into full manic episode
roller-coaster ride into depression involves biological and psychosocial components
when psychotic features are prominent, difficult to diff from schizoaffective and to separate from substance use
Term
Bipolar II
Definition
MDE and hypomanic episodes w/out history of manic episode
onset slightly later (20s)
risk for developing Bipolar I
Term
Cyclothymia
Definition
involves periodic elevation and depression of mood w/out MDE or hypomanic episode
less frequently present to clinic
at risk for MDE or manic episode
Term
Bipolar Disorder Heritability & Biological Issues
Definition
50%, very high
increased glucose metabolism during mania seen in PET scans
low SE and high NE= mania: 'permissive theory'
lesions in right orbitofrontal lobe (stroke)
manic episodes may be damaging to the brain
disordered sleep assoc with high risk of manic episode w/ bipolar
Term
Bipolar Disorder Pharmacological Tx
Definition
Meds necessary to prevent manic episodes
lithium carbonate: naturally occurring salt (poisonous), very effective but narrow window, action unknown
antipsychotics
mood stabilizers: also used in tx of seizures, action unknown, increasingly more common
Term
Bipolar Disorder Psychological Tx
Definition
Psychoeducation
Medication management
IPT/CBT
Family-focused treatment (FTT)
Interpersonal and Social Rhythm Therapy: same components as IPT, grieve loss over 'healthy selves', track social routines and habits to see connections w/ mood states
Term
Suicide
Definition
Every mental disorder is linked with suicide
22% psychologists experience cl suicide
Risk Factors:
caucasian, men (for completion), over 70 (60 for men), family history (genetics), psychological disorder, limited social support, adolescents
Term
Suicide Assessment
Definition
SLAP Domains:
Specificity of plan
Lethality of method
Availability of means
Proximity of helpers

On a continuum
Term
Suicide Tx
Definition
Suicidal ideations are common
Risk minimalization:
enlisting support of others, removal of means, hospitalization
Contracting for safety:
written, signed, collaborative project
time-oriented
Term
Somatoform Disorder Types
Definition
*Hyesterical Type (Physical Change):
Somatization Disorder
Conversion Disorder
Pain Disorder
*Preoccupation Type (No Physical Change):
Hypochondriasis
Body Dysmorphic Disorder

Psychophysiological disorders
Term
Somatoform Hysterical Type Disorders
Definition
Shared features:
Physical sx/ concerns without physiological/ rational basis
Prominent relationship btw psychosocial stressors and symptoms
Secondary gain aspects (attention, excuse)
Family & employment complications
NOT INTENTIONALLY FAKING
(not malingering/ factitious disorder)
Term
Common Presenting Features Hysterical Somatoform Disorders
Definition
Disability status + utilization of health care svcs= high societal cost
experience physical symptoms w/out identifiable physical cause:
referral for psychological help after exhausting everything else
many meds
frustrated w/ physicians and visa versa
Psychiatric sx typically expressed in relation to physical sx
Term
Somatization Disorder Features
Definition
extensive history of sx
life revolves around sx
multiple and varied sx req'd:
pain x4
gi x2
sexual/reproductive
pseudoneurological
onset before age 30, chronic course- personality disorder?
Term
Somatization Disorder Demographics
Definition
DSM diagnosable rare, but subclinical w/ distress & disfunction common
(undifferentiated somatoform requires only 1 physical complaint)
typical= low SES, unmarried women; generally starts in teens
anxiety, depression, & substance abuse co-morbid
Term
Somatization disorder Psychological Components
Definition
Impulsivity, poor delay of gratification:
short-term gain from somatic problems and yeilds long-term isolation
pleasure seeking (sex, drugs)
manipulative behavior prominent:
sick role, parasuicidal
Term
Somatization Disorder Biological Components
Definition
genetic component w/ link to anti-social pd
low SE yields increased pain reception
Term
Somatization Disorder Tx
Definition
Difficult to treat, similarities to Cluster B personality disorders, no empirically-supported tx
Psychological Treatment Components:
accept somatic complaints as valid
stable level of contact regardless of symptom exacerbation
goal of minimizing utilization of health care services (exams, tests, meds, etc)
No Pharmacological Tx
Term
Conversion Disorder Features
Definition
at least one symptom or deficit of sensory or voluntary motor function
DSM specifiers:
motor symptom or deficit
sensory sx or deficit
with seizures or convulsions
with mixed presentation
Sx presentation assoc with significant psychosocial stressor-episodic
Presented dramatically w/out corresponding concern
Term
Conversion Disorder Demographics
Definition
relatively rare
much higher in developing countries
Term
Conversion Disorder Psychological Components
Definition
Primary gain- relief of anxiety "the symptom binds anxiety"
secondary gain- "sick role"
sexual abuse history
inability to cope with emotional distress
modeling relatives
personality disorders common (histrionic, passive-aggressive/dependant)
more short lived= easier to treat
Term
Conversion Disorder Tx
Definition
no empirically-supported tx
psychological tx components:
emotional support for precipitating stressor
explaining that not all sx have definite physical cause
expectation that sx will quickly wane
reinforce improvements & symptoms reduction
removal of secondary gain
Pharmacological:
anxiolytics or antidepressants for associated problems
Term
Pain Disorder Features
Definition
Psychological factors have "important role in onset, severity, exacerbation, or maintenance of pain"
DSM Specifiers:
"with associated psychological factors" when psych factors have major role
"with both psych factors and a general medical condition" when both play important roles
Acute/chronic= -/+ 6 months
Term
Pain Disorder Considerations
Definition
Current Meds: potential for abuse/dependence?, how long taking, motivation for pain relief, addicted?
legal issues?
nature of overt pain behavior: consistency, level of drama, contextual?
Term
Pain Disorder Demographics/Co-morbidity
Definition
Psychiatric co-morbidity very common:
Acute pain assoc w/ anxiety disorders
Chronic pain assoc w/ depressive disorders
Term
Pain Disorder Psychological Components
Definition
Pre-existing psychiatric condition as risk factor
Related to guilt- experience of pain is atonement for sins
"sick role"
coping strategies-helpful vs maladaptive
conversion of emotional distress to physical distress b/c more acceptable?
Term
Pain Disorder Biological Components
Definition
Gate control theory: pain signals from body entering spinal cord are modulated by signals sent from brain- SE modulates signals from brain
Endorphins:
levels are lower in Pain Disorder pts
levels are related to sense of self-efficacy
Term
Pain Disorder Gender Differences
Definition
Source of pain:
Women- fibromyalgia, migraines, arthritis, carpal tunnel, TMJ
Men- cardiac pain, backache
women report more pain, greater severity
Term
Pain Disorder Psychotherapeutic Tx
Definition
CBT effective for disability & distress:
support and validation of pain as real
relaxation training
activity scheduling
reinforcement of non-pain behaviors
cognitive restructuring
Biofeedback for migraines, tension headaches, and muscle tension states
Physical therapy for pain
Hypnosis: used for altered perceptual experiences, images assoc w/ pain modified to be less distressing
Term
Pain Disorder Pharmacological Tx
Definition
Analgesics not effective & assoc w/ serious potential for abuse
TCA's better than old SSRIs
Cymbalta very effective (SE & NE)
Neurontin/ Tegretol for neuropathic pain
Term
Hypochondriasis Features
Definition
anxiety surrounding fears of having a serious illness 2/2 misinterpretation of bodily sx
cannot be convinced that nothing is wrong
frequent visits to doctor
usually comorbid w/ anxiety/depression
relationship to Panic Disorder:
misinterpretation of physical sx
panic has fear of immediate consequences, Hypochondriasis has fear of long-term consequences
Term
Hypochondriasis Biological Components
Definition
Non-specific genetic contribution for anxiety
deficit in autonomic down-regulation
aberrant cortisol levels
Term
Hypochondriasis Cognitive Components
Definition
focused attn on physical sensations
hypersensitivity to threat
espousal of Western concept of health as being "free from sx(sensations)"
Possible learned component:
modeling from parents
benefits of "sick role"
Term
Hypochondriasis Contextual Components
Definition
onset during stressful life event
high incidence of verifiable medical illness in family
psychological sx
increasing prevalence w/ age related to fear of aging and dying
Term
Hypochondriasis Tx
Definition
Not well studied
Psychotherapy:
CBT
Reassurance/Explanation
(similar to tx for anxiety)
Pharacological:
antidepressants and anxiolytics
Term
Body Dysmorphic Disorder (BDD) Features
Definition
preoccupied w/ something being wrong or misshapen about body part (usually involves face)
not delusional, but overvaluing
not a phobia (no irrational fear)
often seek dermatologist or plastic surgery to "correct"
rates of suicide are high
overlap with OCD
PDs common
Term
Evolutionary Aspects of Eating
Definition
humans are opportunistic eaters
survival required exercise
body developed to process rough food
natural draw toward calorie dense food
Term
Biological Aspects of Eating
Definition
Neuroscience view is that the "resting state" of system is hunger and food consumption provides temporary satiety
Satiety signals to brain **hypothalamus*:
stomach distension and emptying food into small intestine release CCK
*Ghrelin secreted when stomach is empty
*Leptin secreted when stomach is full
Vomiting:
natural rxn to over-eating, consuming spoiled food
enorphin release- sense of relief
Term
Psychological Aspects of Eating
Definition
provides breaks/structure to the day
Classical conditioning/learning:
family gathering for meals, pleasnat sensation when eating and full
Modeling behavior:
parent & children, peers
Term
Social Aspects of Eating
Definition
focal point of celebrations, context for developing interpersonal relationships- distractor/ barrier, age and gender expectations
Term
Modern Society and Eating
Definition
Body image:
trend over last 50 years for thinner, ideal physique
mass media
Modern society promotes obesity:
processed calorie-dense food
sedentary lifestyle
less time- more meals out & less exercise
Term
Anorexia & Bulimia Nervosa Shared Elements
Definition
Intense preoccupation with food
Intense fear of weight gain
Obsessive thinking & Compulsive behavior
Lack of interoceptive awareness/body cues:
-I get confused about what emotion I'm feeling
-I don't know what's going on inside me
I get confused as to whether or not I'm hungry
Serious health consequences: high rates of death
Term
Anorexia & Bulimia Nervosa Frequent Family Dynamics
Definition
Perfectionistic parents
Over-involved parents: father domineering, high sense of importance placed on external evaluation, restrictive eating and purging as means of exerting control, child's sense of self enmeshed w/ parents- lack of body cues
Lack of conflict resolution:
open/expressed conflict levels low, not ok to talk about feelings, etc
*family tx important
Term
Anorexia & Bulimia Nervosa Sociocultural Components
Definition
relatively new phenomenon
most are female, caucasian, upper-middle class- this is changing
onset age for anorexia (13), bulimia (17)
almost non-existent in non-western societies- but this is changing
Term
Anorexia Nervosa Primary Criteria
Definition
Failure by choice to maintain adequate weight "Refusal"
85% of normal weight
due to restricted eating, purging, and exercise
weight loss does not reduce fear of gaining weight
distorted perception of body weight and size
amenorrhea for at least 3 months (DSM V proposed to remove this)
Term
Anorexia Nervosa Subtypes
Definition
Restricting Type: dieting, fasting, exercise (most typical)
Binge-eating/Purging type: vomiting, laxatives, diuretics, enemas & 85% normal body weight (less common)
Term
Anorexia Nervosa Physiological Fallout
Definition
damage to brain & heart=death
lethary
lower calcium=brittle bones
hypothyroidism
brittle nails & hair
lunago (tiny hairs to warm)
dehydration=constipation
mild anemia
swollen joints
2-6% die*
Term
Anorexia Nervosa Psychological Issues
Definition
depression (either first or 2/2 starvation)
shame: baggy clothes, hiding food, etc
frequent co-morbidities:
anxiety disorders
intermittent explosive disorder
personality disorders
substance-abuse disorders
suicide risk

Perfectionistic
Term
Bulimia Nervosa Primary Criteria
Definition
binge eating
sense of loss of control while eating
compensating action: vomiting, laxatives, diuretics, enemas, fasting, excessive exercise ( last two non-purging type)
at least twice/week for 3 months (DSM V change to once/week)
self-eval unduly influenced by body shape & weight
normal or higher weight (not anorexia)
specify purging and non-purging types (DSM proposed removal of subtypes)
Term
Bulimia Nervosa Biological Fallout
Definition
From purging (also in Anorexia Nervosa Purging Type)
stomach rupture
loss of vital minerals (e.g., potassium)=heart failure
stomach acid corrodes teeth and esophagus
scarring to backs of hands
irregular menstruation
Term
Bulimia Nervosa Psychological Issues
Definition
shame/secretiveness:
multiple binges in different groups, hiding food, hiding laxatives, hiding vomit
frequent co-morbidities:
anxiety disorders
depression
OCD
substance abuse
impulsivity problems
cluster B personality
suicide risk
Term
Biological Perspective Bulimia Nervosa
Definition
genetic component
dysfunction in hypothalamus
hypersensitivity to endorphins from purging-yields net gain in pleasure
low levels of SE and NE: assoc w/ binging, ssris increase SE activity and counter binging and purging
Term
Bulimia Nervosa Specific Psychological Perspectives
Definition
Learning:
binge-eating associated with relief from anxiety & negative affect
pleasant sensation following purging
purging regains sense of control

Modeling Behavior:
learning techniques from friends, teammates, TV
websites w/ techniques
Term
Anorexia Nervosa Tx
Definition
Goals:
healthy eating habits
healthy weight
resolve psychological problems

venues:
majority outpatient (freq w/ hospitalizations)
inpatient
Term
Anorexia Nervosa Outpatient Tx
Definition
cognitive-behavioral
interpersonal
family-based therapy:
behavioral family systems therapy- control over eating, cognitive restructuring, problem-solving, communication
individual based therapy produces improved family functioning
Educational
Term
Anorexia Nervosa Inpatient Tx
Definition
Effective for restoring weight
Behavioral psychotherapy- token economies
Short-term improvement not predictive of long-term outcome
Term
Anorexia Nervosa Pharmacological Tx
Definition
usually co-morbid disorders
MUST restore weight first
not effective by itself
antidepressants (ssris)
antipsychotics (severe OCD)
Term
Bulimia Nervosa Psychological Tx
Definition
Cognitive Behavioral Therapy:
preferred by pts over antidepressants
superior to antidepressants
may not be better w/ antidepressants

Interpersonal psychotherapy: similar results as CBT after 1 yr
Term
Bulimia Nervosa Pharmacological Tx
Definition
Antidepressants: ssris, high doses prozac
Mood stabilizers: lithium
other meds for co-morbidities
Term
Binge Eating Disorder
Definition
proposed for DSM V
recurrent episodes of binge eating & 3+:
eating more rapidly
until uncomfortably full
large amounts when not hungry
alone out of embarrassment
feeling disgusted or guilty over eating

a sense of loss of control when binging
distress over binge eating
occurs at least 1/week for 3 months
no compensatory bx
Term
Substance Use Levels of Involvement
Definition
Use
Intoxication
Abuse-less serious, but will become..
Dependence: physiological
psychological='without physiological'
Term
DSM-IV Criteria Abuse
Definition
Maladaptive pattern of substance use leading to significant impairment &/or distress during same 12 month period, includes 1+ from recurrent use:
failure to fulfill major role obligations
use in situations when it is physically dangerous
despite legal problems
despite persistent social/interpersonal problems caused by substance
Term
DSM-IV Criteria Dependence
Definition
maladaptive pattern of substance use leading to significant impairment &/or distress
includes 3+:
tolerance
withdrawals (substance specific)
substance taken in larger amts than intended
unsuccessful efforts to cut down/control
sig time spent acquiring, using, recovering
social, occupational, recreational activities sacrificed
continued use despite physical & psychological problems caused/exacerbated by substance
Term
Substance Use Disorder Proposed for DSM V
Definition
encompasses both abuse and dependence
maladaptive pattern of substance use leading to significant impairment &/or distress during 12 month period, includes 2+:
failure to fulfill major role obligations
use in physically hazardous situations
despite persistent social/interpersonal problems caused
tolerance
withdrawal
substance taken in larger amts than intended
unsuccessful efforts to control use
sig time spent acquiring, using, or recovering
social, occupational, recreational activities sacrificed
Term
Effects of Substances
Definition
increased release of DA in mesolimbic area of brain (learning, reward, motivation)
-psychological dependence may involve 2/2 elevations in DA

Adaptive physiological changes in brain and organ systems to accommodate use:
tolerance
withdrawal (symptoms opposite primary effects)
conditioned compensatory response
Term
Substance Use Disorder Common Presenting Issues
Definition
tremendous co-morbidity w/ axis-I and II disorders (chicken-egg)
polysubstance disorder very common
may not be presenting issue/complaint
?s:
current intoxication
acute withdrawal symptoms
honesty/accuracy in reporting
motivation for tx
legal issues
financial instability
primary soical support network: using/non-using, instability or lack of, co-dependency issues
restricted social/recreational activities
cognitive impairments
Term
Substance Use and Genetics
Definition
may be more important in males: males w/ adhd and alcoholic father at highest risk
reciprocal gene-environment
environment plays role in use, genetics important for abuse/dependence
physiological response to substances
everyone reacts differently bc of different brain structures, genes
Term
Substance Use Brain Systems
Definition
DA critical in use/abuse/dependence:
pleasure pathway=VTA-NA-frontal lobe
stimulated by most abused drugs
natural experiences cannot cause same effects
GABA system:
reduces fear/inhibition
increased GABA-increased DA in Pleasure Pathway
Term
Substance Use Psychological Perspectives
Definition
Positive reinforcement:
direct from substance
perceived psychosocial benefit
Negative reinforement:
removal of negative state (affect/anxiety)
removal of withdrawal symptoms

Cues for cravings: relapse part of disorder
Term
Substance Use Cognitive Perspective
Definition
Cognitive abilities:
recognize problem, problem-solve, flexibility all impaired w/ usage

risk vs. reward perception
Term
Substance Use Social Perspectives
Definition
availability/acceptability in community
parental use:
limited supervision of children, justify parent's lifestyle
co-dependency in relationships
social sphere: social network activities formed around use
Term
Substance Use Tx
Definition
Prochaska & Diclemente- Stages of Change:
pre-contemplation, contemplation, preparation, action, maintenance--relapse or stable behavior

inpatient:
detox (often in jail or hospital)
rehab- usually after acute detox, stay 2-6 weeks, wide range in effectiveness, theoretical orientation, professional staffing, costs
Term
Motivation Interviewing/Enhancement for Substance Use
Definition
idea is enhance intrinsic motivation for change in behavior
focus on ambivalence
central tenets:
subtly directive, acknowledge benefits of use "devil's advocate", non-confrontational
evidence suggests very effective, occasionally w/ single session
Term
Alcoholism & Narcotics Anonymous
Definition
12 step program
central tenets:
abstinence-based
no professional oversight or political affiliations
anonymity
sponsorship
effective when followed, but high dropout rate
Term
Cognitive-behavioral Tx Substance Use
Definition
Cognitive:
objective evaluations of benefits of use vs abstinence, identifying & challenging thoughts, slowing down "rush to recovery"
Behavioral:
avoidance of "high-risk" situations/relationships
encourage activities incompatible w/ use
rewarding abstinence
develop refusal skills via role-playing
typically, AA involvement
Term
Alcohol Tx Pharmacological
Definition
Antabuse (disulfram): disrupts metabolism of ETOH-produces flushing, throbbing headache, nausea, etc.
Term
Pharmacological Tx Other Substances
Definition
Opiates: Methadone, buprenorphine
Cocaine: ssris for dysphoria
Methamphetamine: Buproprion (Wellbutrin)
Nicotine: Nicotine replacement, chantix very effective
Marijuana: n/a
Term
definition of schizophrenia
Definition
"split-mind"
splitting of personality
emotion and intellect incongruent
fundamental break w/ reality that is out of the rang of "normal"--psychotic
NOT more violent
DSM-IV:
6+ months with 1+ month active phase
2 or more Positive/Negative symptoms
social/occupational dysfunction
subtypes
Term
positive symptoms schizophrenia
Definition
delusions
hallucinations: usually auditory
disorganized speech: loose associations, tangentiality, derailment, neologisms, "clang"
bizarre/disorganized behavior: appearance, affect, actions
Term
negative symptoms schrizophrenia
Definition
alogia: not speaking
affect flattening
avolition: no motivation
anhedonia: lack of pleasure
Term
other common problems w/ schizophrenia
Definition
attention
dysphoria
memory
poor emotion recognition
absence of insight
sleep disturbance
suicide attempts
Term
Paranoid subtype schizophrenia
Definition
most common
appear the most "normal"
later average onset
absence of disorganized speech/behavior
symptoms tend to wax and wane
Term
disorganized (hebephrenic) subtype
Definition
problems present at early age
most obviously psychotic
must have disorganized speech/behavior and flat affect
less symptom fluctuation
Term
catatonic subtype
Definition
rare
motor immobility, mutism or marked negativism, peculiar behavior, echolalia
Term
undifferentiated subtype
Definition
meets crit for none of the other subtypes
Term
residual criteria schizophrenia
Definition
pt no longer meets criteria
rarely used; better to use original diagnosis w/ "episodic w/ interepisode residual symptoms" or "single episode in partial remission"
*DSM-V to remove subtypes
Term
schizophrenia course specifiers
Definition
*used only after one year since onset:
continuous
episodic with interepisode residual symptoms
episodic with no interepisode residual symptoms
single episode in partial remission
single episode in full remission
Term
schizophrenia course
Definition
Prodromal: peculiar behavior, social isolation/withdrawal, decreased role function, not unlike social phobia
Active
Residual: decreased positive symptoms, negative symptoms remain*
Term
schizophrenia prevalence
Definition
more severe in men
greater in lower SES and blacks
age onset: late teens, early 20s
-related to stress of emancipation
-"prodromal period"-time from initial presentation of symptoms to diagnosis (usually first psychotic break)
generally seen as lifetime disorder
Term
impact of schizophrenia
Definition
individual: interruption of education, loss of independence, loss of social network, employment difficulties, substance abuse, homelessness, imprisonment, suicide
family: economic & emotional burden, guilt, stress, "friction", mood disorders
society: unemployment, extended and chronic hospitalizations, imprisonment, homelessness, loss of valuable contributing members
$20,000-$100,000+ patient/yr
Term
genetics schizophrenia
Definition
clear genetic & environmental issues
mz twins 50% concordance
17% parent-child transmission
risk increases w/ increased number of affected family members
Term
brain differences schizophrenia
Definition
increase in size of ventricles
decrease in size of subcortical structures
asymmetry
altered neurochemistry: DA most widely known, but not sole precipitant
Term
etiology DA schizophrenia
Definition
higher # of D2 receptors: positive symptoms
underactive D1 in prefrontal cortex: negative symptoms
Term
etiology other neurochemicals schizophrenia
Definition
SE: well-supported, explains efficacy of atypical antipsychotics
Glutamate: explains cognitive deficits & developmental changes, provides causal mechanism for DA
GABA: explains glutamate dysfunction
Neurotensin: master modulator for all systems
Term
etiology neurodevelopment schizophrenia
Definition
childhood: extensive white matter tracts and synapses from connecting gray matter
*synaptic pruning: process occurring in adolescence where number of synapses decrease based on use...
**in schizophrenia: excessive/inappropriate synaptic pruning may take place-
frontal lobes=problem solving, organized thought
temporal lobes=auditory hallucinations
thalamus=sensory gating
Term
etiology environmental influences schizophrenia
Definition
cold mother=NO
double-bind communication: inconsistent messages=NO

viral infection: exposed during 2nd trimester
childhood exposure to toxoplasma gondii, cat feces
major life stressors/trauma
parental influences
Term
etiology symptom relapse schizophrenia
Definition
social withdrawal early warning sign, isolation as precipitant
high psychosocial stressors
much higher risk when alcohol/drugs involved
can be effectively managed w/ meds to avoid fallout
Term
treatment schizophrenia meds
Definition
Typical antipsychotics/neuroleptics: mechanism of action- block DA
reduce positive symptoms but ignore or make worse negative symptoms
side effects- difficulty initiating movement, tardive dyskinesia (involuntary facial movements)
used in severe cases and for crisis intervention
cigarette smoking assoc w/ better outcome and med compliance

Atypical antipsychotics:
mechanism of action- decrease sensitivity of DA & SE in specific pathway, may alter physiology of neurons
reduce positive symptoms, indirectly reduce negative symptoms
less risk for tardive dyskinesia
VAST improvements for many patients, less side effects, de-institutionalization
Term
treatment schizophrenia inpatient
Definition
very expensive
temporary (7-30 day) stays for psychotic breaks
many facilities are state-funded, house 30-1000+ patients
strict rules, various levels of security
mixed-gender community activities, token economies
Term
treatment schizophrenia residential homes
Definition
typically non-descript in residential neighborhoods
state/local funds to house patients previously hospitalized
idea is to teach patients skills necessary for independent living: cooking, cleaning, meds, hygiene, communication, problem-solving, etc
Term
treatment schizophrenia family-based- history I
Definition
first family therapies in 1950s
negative change in patient behavior when interacting w/ family=family system as pathological entity
results:
family contact prohibited, confrontational approach to therapy
poor-negative outcome, dangerous
Term
treatment schizophrenia family-based history II
Definition
renewed interest in 70's due to inability of meds to prevent relapse
*Expressed Emotion (EE) in family and relapse
theory shift: family environment affects course rather than onset, family beliefs, interactions, and behaviors as target for tx
medication improvements especially Atypicals, many patients living w/ family
Term
family-based tx general description (schizophrenia)
Definition
main goals: psychoeducation & stress reduction
treatment length: 9+ months, weekly to monthly
setting: clinic & home
group: single & multi-family
inclusion of extended family
Term
family-based tx major issues (schizophrenia)
Definition
beliefs & attitudes toward patient and mental illness
reduce shame & guilt
stress management
family interaction style-EE
coping skills
community resources
Term
family-based tx benefits (schizophrenia)
Definition
patient:
symptom reduction
med compliance, less meds needed
improve social functioning

family:
increase knowledge of illness & change beliefs
decrease EE
change in interaction style
improve problem solving skills
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