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General Pathology Chapter 6 Cytokines/mediators
Robbins and Contran Pathology
24
Pathology
Graduate
09/14/2011

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Term
CD2
Definition
found on T cells
Term
CD3
Definition
found on T cells
Term
CD4
Definition
found on T cells, bind MHC class 2
CD4+ T cells regulate other T cells, B cells, Macrophages, NK cells
Term
CD8
Definition
found on T cells, bind MHC class 1
Term
IL-2
Definition
secreted by Th1 cells, recruit more T cells, key in delayed type hypersensitivity
Term
IFN-y
Definition
secreted by TH1 cells
major macrophage activating factor
Term
IL-4
Definition
secreted by Th2 cells, turns on IgE-producing B cells, responsible for hypersensitivity type 1
Term
IL-5
Definition
secreted by TH2 cells and mast cells, activates eosinophils MOST POTENT!
Term
IL-13
Definition
secreted by TH2 cells, promotes IgE production and mucus secretion
Term
IL-17
Definition
secreted by TH17 cells
Term
IL-22
Definition
secreted by TH17 cells
Term
CD40
Definition
expressed on B cells, bind CD40 ligand for B cell activation
Term
CD40 ligand
Definition
Expressed on T cells, activate CD40 that is expressed on B cells and enable them to mature
Term
CD16
Definition
Fc receptor for IgG, expressed on NK cells for ADCC
Term
CD56
Definition
found on NK cells
Term
NKG2D
Definition
stimulatory protein expressed by virally infected or tumor cells and recognized by NK cells
Term
IL-3
Definition
secreted by TH2 cells and mast cells, activates eosinophils
Term
IL-12
Definition
produced by macrophages and critical for inducing the TH1 response, seen in delayed type hypersensitivity
Term
CD28
Definition
located on T cells, co-stimulation requirement for activation based on ligand on APCs
Term
CD25
Definition
on regulatory T cells (CD4+) that prevent immune reactions against self-antigens
Term
IL-7
Definition
responsible for the proliferation of lymphoid progenitors (especially T cell precursors)
Term
Histamine
Definition
PRIMARY MEDIATOR
smooth muscle contraction, increased vascular permeability, increased nasa, bronchial, and gastric secretion
Term
Leukotriene C4 and D4
Definition
most potent vasoactive and spasmogenic agents known
Term
leukotriene B4
Definition
highly chemotactic for neutrophils, monocytes, and eosinophils
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