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Gene 302
Lecture 1
45
Other
Undergraduate 4
01/21/2012

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Term
Genetics
Definition
The study of biologically inherited traits.
Fixed genetic info passed from one generation to the next.
Term
Genetics must exlpain:
Definition
Overall constancy of inherited trait and uniqueness of each individual.
Term
Systematics
Definition
Categorization of organisms into species
Term
Species
Definition
The largest and most inclusive reproductive communities of sexual and cross fertilizing individuals that share in a common pool of genetic material.
Term
Each species has a:
Definition
Unique set/combination of inherited characteristics, which make it different from other species.
Term
The general criteria for species are:
Definition
Mating, divergence, and similar environments.
Term
Mating
Definition
A group of individuals or organisms that are held together by the ability to exchange genetic material (this is a 'cohesive force')
Predominance
Term
Divergence
Definition
Species divergence is irreversible (if two species can go back to interbreeding then they were not really seperate species)
No longer mate with eachother
Term
Similar environment
Definition
Live in or share similar environments (ecotypes) and have similar lifestyles.
Does not have to be in the same location.
Term
How to assign species classification to organisms that do not have a sexual life style?
Definition
To classify prokaryotes, as of 2002, classification is based on DNA sequence criteria.
Term
DNA sequence criteria
Definition
If two prganisms share >70% genome identity and less than 3% sequence difference in the 16S ribosomal RNA (important constituent of the translatonal machinery) then they are the same species
Term
Gene
Definition
A functional unit of inheritance
Term
Phenotype
Definition
All the observable properties (structural and functional) of an organism.
Represents everything in an organism.
Term
Genotype
Definition
The sum of the genetic info contained in an organism
Term
Partial phenotype
Definition
Eye color
Specific
Term
Partial genotype
Definition
All the genes affecting eye color.
Specific
Term
Genotype -> phenotype
Definition
Genotype does not translate to phenotype and the environment has an impact on phenotype.
A genotype specifies a range of possible phenotypes (no direct outcome to phenotype)
Term
How much does environment influence genotype and phenotype?
Definition
The environment may have a small contribution, a profound influence, or each stage of development determines the phenotype.
Term
Evolution
Definition
The gradual process by which the living world has been developing following the origin of life.
A change in the genetic composition of a population over time.
Term
Evolutionary changes occur from:
Definition
Primary evolutionary forces, which produce and sort out genetic variations and operate in field of space and time (very long time).
Term
Darwin's Tree of Life
Definition
Ancestors form the trunk of the tree and evolution and species diversity increases toward the top of the tree.
Term
Darwinian
Definition
"spontaneous variation" together with the "struggle for life" by natural selection
Term
Neo-Darwinian
Definition

the observed rate of molecular evolution (mutation) is too fast to be explained by natural selection alone.

Modern day view.

Term
Non-Darwinian
Definition
chance is more important than selection in producing natural diversity. other factors: population size, geographical isolation, genetic drift, etc.
Term

The cell theory

 

Three Criteria

Definition

the cell is the smallest building element of a multicellular organism, and as a unit is itself an elementary organism.

a cell can only be produced from another cell by cell division.

each cell in a multicellular organism has a specific task  to accomplish and represents a working unit.

Term
Living matter - properties (3)
Definition

metabolism (enzymology)

reproduction

evolvability (change)

Term
Won Nobel Prize
Definition
Thomas Cech and Sydney Altman
Term
"Robbed"
Definition
Norman Pace
Term
Metabolism
Definition
self splicing, peptidyl transferase
Term
Reproduction
Definition
with RNA template, new RNA strand can form without replication machinery
Term
Evolvability
Definition
target of mutation
Term
How does RNA meet the criteria for basic life?
Definition

Metabolic: enzyme

Reproduction: self replication

Evolves

Term

True or False:

 

RNA brings genotype and phenotype together.

Definition
True
Term
What is Jack Szostak known for?
Definition

"Clay molds" around RNA that helps with reactions.

Membrane bound compartment that began the hypothesis of cells.

Term
Similarities between prokaryotes and eukaryotes
Definition

Universal genetic code

Major metabolic pathways (N, P, C, and S metabolism) are virtually the same in all organisms.

Chemistry of energy transfer reactions (e.g. thioester bond formation)

Term
Prokaryotes Metabolism
Definition
Aerobic and anaerobic
Term
Eukaryotes metabolism
Definition
Aerobic
Term
Prokaryotes size
Definition
1-10 nm
Term
Eukaryotes size
Definition
5-100 nm
Term
Prokaryotes compartments and organelles
Definition
Few or none
Term
Eukaryotes compartments and organelles
Definition

Many

Always nucleus and mitochondrion

Term
Prokaryotes organization
Definition
Mostly unicellular
Term
Eukaryotes organization
Definition
Unicellular or multicellular
Term
Cyanobacteria
Definition
They can live on sunlight, air, and water alone: they use ("fix") CO2 and N2 straight from the atmosphere to produce oxygen.
Term
Cell to Cell communication
Definition
spatial pattern of organism
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