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Gastrointestinal
Gastrointestinal COMLEX 2
274
Medical
Graduate
05/07/2015

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Term
where is ethanol absorbed
Definition
stomach
Term
where is folate absorbed
Definition
duodenum
Term
where is thiamine absorbed
Definition
ileum
Term
signs of perforation
Definition
sudden onset peritoneal signs (gaurding, rebound, silent abdomen), generalized, hematemesis, free air under diaphragm, limits movement, hypotension, tachycardia
Term
#1 cause perforation
Definition
peptic ulcer
Term
signs of peritonitis
Definition
generalized acute abdomen, fever, leukocytosis
parencentesis PMN >250, high protein, low glucose, LDH>serum LDH
Term
treatment of peritonitis
Definition
ceftriaxone and gentamycin
Term
#1 cause lower GI bleed >60yo
Definition
angiodysplasia
Term
indicators of upper GI bleeding
Definition
hematemesis, coffee groung emesis, melena
Term
indicators of lower GI bleeding
Definition
hematoschezia, increased HR, light headed, hypotension
Term
what mimics melena
Definition
bismuth, Fe, spinach, charcoal, licorice
Term
definition of diarrhea
Definition
bowel movements with increased liquid >200g/d stool
acute <2wk, chronic >2wk
Term
define and causes of secretory diarrhea
Definition
osmotic gap <50
VIPoma, gastrinoma, medullary thyroid CA, enterotoxic bacteria, laxative, carcinoid tumor
Term
define and causes of osmotic diarrhea
Definition
osmotic gap >50
malabsorption (celiac, whipple, pancreatic insufficiency, lactose), milk Mg
Term
define and causes of inflammatory diarrhea
Definition
osmotic gap <50
autoimmune, immune suppression, chronic infection
Term
what acid base disorder does diarrhea cause
Definition
metabolic acidosis and hypokalemia
Term
#1 cause of chronic diarrhea in adults
Definition
lactose intolerance or IBS
Term
#1 cause of acute diarrhea in adults and kids
Definition
adults norovirus
kids rotavirus
Term
what antacid causes diarrhea
Definition
Mg
Term
what virus causes diarrhea in the summer
Definition
cosackie and echo
Term
signs of adenovirus infection
Definition
URI, pink eye, diarrhea
Term
ETEC: diarrhea, fever, cause, length, leukocytosis, lactose, H2S, tx
Definition
watery
fever
travelers (water, food)
lasts 2d
no leukocytosis
lactose positive
no H2S
tx hydration
Term
EHEC: diarrhea, fever, cause, leukocytosis, lactose, H2S, culture, tx, complications
Definition
bloody diarrhea
fever
raw meat with poo
leukocytosis
lactose positive
no H2S
shiga like toxin
hydration (abx cause toxin release)
HUS, TTP
Term
salmonella: diarrhea, fever, cause, onset, length, leukocytosis, lactose, H2S, culture, tx
Definition
watery or bloody
possible fever
poultry, milk, produce
24-48h onset
lasts 1wk
leukocytosis
no lactose
makes H2S
black growth
hydration, abx prolong carrier, fluoroquinolone if compormised
Term
shigella: diarrhea, fever, cause, length, leukocytosis, lactose, H2S, culture, tx, complications
Definition
severe bloody
possible fever
food, water, crowding
lasts 1wk
leukocytes
no lactose
no H2S
actin polymerization and shiga toxin
cipro, TMP-SMX
HUS
Term
C. diff: diarrhea, fever, cause, onset, culture, tx, complications
Definition
watery or bloody
fever
clindamycin, ampicillin, any abx
onset in 6wk
C.diff toxin, pseudomembranes
metronidazole or vancomycin
toxic megacolon, perforation
Term
S. aureus: diarrhea, fever, cause, onset, length, leukocytosis, culture, tx
Definition
watery
no fever
mayo, meat
onset 1-6h
duration 24h
no leukocytes
preformed toxin
hydration
Term
C. perfringens: diarrhea, fever, cause, length, leukocytosis
Definition
watery
no fever
food
onset 12-24h
lasts 24h
no leukocytes
Term
camplobacter: diarrhea, fever, cause, length, leukocytosis, culture, tx, complications
Definition
bloody
fever
poultry, food
duration <1wk
leukocytes present
spirals in 3D (C/S in 2D)
erythromycin
guillian barre
Term
C. botulinium: diarrhea, fever, cause, culture, tx, complications
Definition
watery
no fever
disseminated from wound, honey, home canned food
gastric toxin, spores
gastric lavage, antitoxin in adults
descendning flaccid paralysis
Term
Y. enterolytica: diarrhea, fever, cause, treatment
Definition
bloody
fever
pork, puppy poo
hydration
Term
V. cholera: diarrhea, fever, cause, culture, treatment
Definition
rice water
fever
seafood, water
slight curve, GNB, flagellum
tetracycline
Term
V. parahemolyticus: diarrhea, fever, cause, treatment
Definition
watery
no fever
oysters
hydration
Term
giardia: diarrhea, fever, cause, culture, treatment
Definition
greasy, smelly
no fever
water, forest
cysts and trophites
metronidazole
Term
bacillus cereus: diarrhea, fever, cause, treatment
Definition
watery
no fever
rice
hydration
Term
E. histolytica: diarrhea, fever, cause, culture, treatment, other symptoms
Definition
bloody
no fever
water, forest
cysts and trophoites
metronidazole
LIVER ABSCESS
Term
cyptosporidium: diarrhea, fever, cause, culture, treatment
Definition
watery
no fever
food, water, AIDS
acid fast parasites
nitazoxanide
Term
trichhinella: diarrhea, fever, cause, culture, treatment, other symptoms
Definition
watery
fever
pork
eosinophilia
albendazole/melbendazole
periorbital edema
Term
taniasis (tanea solium): diarrhea, fever, cause, culture, treatment
Definition
watery
no fever
pork
tapeworm in gut
praziquantel, albendazole
Term
cysteriosis cause, tx
Definition
T. soleum cyst/egg ingestion, causes cysts in brain and muscle

tx praziquantel, albendazole, steroid if CNS
Term
how does shiga toxin work
Definition
irreversibly nicks 60S ribosome inhibiting protein synthesis causing cell death
Term
how does salmonella cause toxicity
Definition
elicts immune response that increases intracellular cAMP
Term
how does cholera cause toxicity
Definition
toxin binds to stimulatory G proteins increasing intracellular cAMP
Term
complications of constipation
Definition
hemorrhoids, rectal prolapse, anal fissures, fecal impaction
Term
manning criteria for IBS
Definition
pain relieved by defecation, stool frequency increases after onset of pain, stool becomes looser following onset of pain, visible abdominal distension, passage of mucous with stool feeling of incomplete defecation
Term
ROME II criteria for IBS
Definition
12wk symptoms + abdominal pain + 1 minimum from below...

relief with defecation, change in frequency of stool, change in form of stool
Term
what do these types of vomiting indicate: bilious, feculent, undigested food, coffee ground or blood, with diarrhea, with headache or visual change, with abdominal pain
Definition
bilious: obstruction distal to ampulla of vater
feculent: distal intestinal obstruction, bacterial overgrowth, gastrocolic fistula
undigested food: increased ICP, pyloric stenosis
coffee/blood: GI bleeding
diarrhea: gastroenteritis
abdominal pain: peritonitis, cholecystitis
headache/visual: increased ICP
Term
#1 salivary gland tumor
Definition
pleomorhic adenoma, benign
Term
define nonulcer dyspepsia
Definition
multiple epigastric symptoms (heartburn, indegestion, bloating, pain), diagnosis of exclusion after all testing including endoscopy without cause, present for minimum 4wk
Term
treatment of GERD
Definition
1) avoid fatty foods, coffee, meals before bed, smoking, etc
2) antacids and meals and bed time
3) H2 blockers
4) SWITCH to PPI
5) add promotility agent (metocropramide, bethenchol)
6) add H2 blocker back on
6) nissen fundoplication
Term
pathogenesis of barretts esophagus, tx
Definition
stratified squamous replaced with columnar, risk of turning into adenocarcinoma
caused by chronic GERD
tx PPI
Term
cause and location of esophageal SCC
Definition
AA, male, alcohol, tobacco, nitrosamines, betel nuts, hot foods, plummer vinson, nasopharyngeal carcinoma
UPPER AND MID ESOPHAGUS
Term
cause and location of esophageal adenocarcinoma
Definition
GERD, barretts, caucasian, male, alcohol, tobacco
DISTAL 1/3, GE JUNCTION
Term
what are good prognostic indicators for esophageal cancer
Definition
stages 0-2a (invading lamina propria, submucosa, muscularis, or adventitia without any node involvement) because it allows for total esophagectomy
Term
achlasia pathogenesis and signs
Definition
motor disorder of esophageal smooth muscle, LES wont relax, no peristalsis

dysphagia of SOLIDS AND LIQUIDS, regurgitation, ASPIRATION, sitting up straight helps overcome it, twisting body or neck to air in peristalsis
Term
achlasia causes
Definition
idiopathic #1, adenocarcinoma of proximal stomach, chagas, scleroderma
Term
test of choice for achlasia
Definition
manometry with increased LES pressure, secondary is barium swallow with birds beak sign and megaesophagus
Term
achlasia treatment
Definition
nitro, CCB, botulism, dilation, heller myotomy
Term
diffuse esophageal spasm cause, sx, tx
Definition
non-peristaltic contraction, LES is normal

noncarciac CP, radiation to jaw, back, arm, dysphagia, NO REGURGITATION, manometrry with non-peristaltic contraction, barium with corkscrew pattern

nitrates, CCB, TCA
Term
explain two types of hiatial hernia
Definition
sliding/1: GI junction and some stomach herniate through (assoc GERD)

paraesophageal/2: stomach herniates into thorax, GE stays below (assoc strangulation)
Term
treatment of mallory weiss syndrome
Definition
90% stop on own, acid suppression promotes healing
can give epinepherine, vasopressin
severe electrocautery, laser procoagulation, angiographic embolization
Term
signs of borehaaves syndrome
Definition
CXR with pneumomediastinum initially, CT with contrast confirms, sternal pain, fever, leukoctosis
Term
complication of plummer vinson syndrome
Definition
SCC of oral cavity, hypopharynx, esophagus
Term
schatzki's ring cause and appearance
Definition
circumfrential, thin, upper to mid esophagus

alkali/acid, bleach, deteegent ingestion
Term
zenker's diverticulum cause, sx, tx
Definition
failure of crycopharyngeal muscle to relax increasing pressure and causing outpouching of UPPER 1/3 OF ESOPHAGUS

dysphagia, halatosis, regurgitation, change in voice, neck mass

CRYCOPHARYNGEAL MYOTOMY
Term
traction diverticulia cause, tx
Definition
traction from mediastinal inflammation and adenopathy (pulmonary TB) at MIDESOPHAGUS NEAR TRACHEA BIFURCATION
no treatment, asymptomatic
Term
epiphrenic diverticulia cause, tx
Definition
associated with spastic esophageal dismotility or achlasia
outpouch in LOWER 1/3 ESOPHAGUS ABOVE LES
esophagomyotomy
Term
treatment of esophageal perforation
Definition
small/contained/draining into lumen: IVF, NPO, ABX, H2 blockers

large/pleura communication: open thoracotomy within 24h
Term
signs of esophageal perforation
Definition
CP (retrosternal, chest, shoulder, neck), tachycardia, hypotension, dyspnea, fever, hamman's sign (mediastinal crepitus), pneumothorax, pleural effusion
dx contrast esophagram
Term
signs of candidia, drug, HSV, and CMV esophagitis
Definition
candidia: white plaques
drug: erosion or shedding of lining
HSV: volcano lesion, well circumscribed
CMV: longitudinal ulcer, abdominal pain and distension, watery diarrhea, inclusion bodies
Term
cause of curling and cushing ulcers
Definition
curling: severe burn
cushing: intracranial injury
Term
gastric ulcers: gastric acid, gastrin, eating, time after eating, nocturnal pain, blood type, malignancy risk, cause, age, prevalence
Definition
gastric acid low normal
gastrin high normal
eating increases pain
soon after eating
nocturnal pain uncomon
blood type A
high risk malignancy
H. pylori #1, smoking, NSAIDs
>40yo
more common than duodenal
Term
duodenal ulcers: gastric acid, gastrin, eating, time after eating, nocturnal pain, blood type, malignancy risk, cause, age, prevalence, location
Definition
gastric acid high
gastrin high
eating relieves pain
pain 2-4h after eating
nocturnal pain common
blood type O
low risk malignancy
#1 H. pylori
<40yo
less common than gastric
usually posterior wall
Term
locations of gastric ulcers
Definition
1 (75%)) lesser curvature
2) gastric and duodenal ulcer
3) prepyloric
4) near GE junction
5) gastric body (NSAIDS)
Term
diagnosis of peptic ulcers
Definition
endoscopy is most accurate but isn't needed unless >55yo (required to RO malignancy)
Term
treatment of peptic ulcers
Definition
NSAID: PPI or misprostol (COX2 inhibitor if must have NSAID)

1) PPI
2) H2 blocker
3) protect mucosa: sucralfate, bismuth, misoprostol
4) kill H. pylori
5) if symptoms >2mo get EGD to RO adenocarcinoma
Term
treatment of H. pylori
Definition
PPI + clathromycin + amoxicillin x7-14d
alt metronidazole
if resistant add bismuth
Term
complications of duodenal ulcer
Definition
hemorrhage: erosion of posterior duodenal ulcer into gastroduodenal artery

perforation: usually of anterior duodenal ulcer
Term
zollinger ellison syndrome location, dx, tx
Definition
usually in DUODENUM, some in pancreas

serum gastrin, secretin stimulation test, localize with somatostatin scintigraphy or octreotide scan

resect, if not PPI THEN octreotide
Term
cause of acute gastritis, chronic gastritis 1, and chronic gastritis 2
Definition
acute: NSAID, H. pylori, alcohol, smoking, caffient, stress, shock, sepsis burns, toxin

1: anti-parietal or anti-intrinsic factor

2: H. pylori in antrum
Term
4 types of gastric cancer, describe
Definition
ulcerative: through all layers

polyploidy: soild, projects into lumen

superificial spreading: best prognosis, mucosa and submucosa only

linitis plastica: leather bottle like, thick, rigid, through all layers, decreased elasticity, poor prognosis
Term
risk factors for gastric cancer
Definition
H. PYLORI, pernicious anemia, preserved foods (nitrates, salt), BLOOD TYPE A, JAPANESE, tobacco, alcohol, vitamin C deficiency, male, family history
Term
tumor markers for gastric cancer
Definition
CEA, 2-glycornidase
Term
treatment of gastric cancer
Definition
distal 1/3 of stomach: subtotal gastrectomy and node dissection

middle or upper stomach or invasive: total gastrectomy
Term
5 sites of gastric cancer metastasis
Definition
kurnkenberg tumor: ovarian
blummer shelf: rectal pelvic cul de sac
sister mary joseph: periumbilica
virchow: supraclavicular
irish: left axillary
Term
complications of bariatric surgery
Definition
depression, suicide
Fe, B12, folate, thiamine, vitamin D deficnecy
GERD
dumping syndrome: food inst processed by stomach, it dumps into intestine causing bloating and diarrhea
Term
causes of small bowel obstruction
Definition
A- adhesions #1
B- bulge / incarcerated hernia (#1 in kids)
C- cancer usually colorectal
Term
define: partial, complete, closed loops, open loop, distal, proximal, and strangulated obstruction
Definition
partial: able to pass gas or stool
complete: occasional gas only
closed: lumen occluded at 2 points by band/hernia ring
open: no bands or hernia
distal: distension of proximal segment, vomiting, pain, minimal distension
proximal: minimal vomiting, lots of distension
strangulated: compormised blood, fever, leukocytosis, pain, peritonitis
Term
signs of small bowel obstruction
Definition
high pitched or no bowel sounds
visible peristaltic waves
colicly cramping
nausea and vomiting
dilated loops with lateral like air fluid levels and minimal gas in the colon
Term
treatment of small bowel obstruction
Definition
IVF, K, NG suction, NPO, monitor urine, surgery if no improvement in 12-24h or if complete or strangulated
Term
signs of paralytic ileus
Definition
abdominal pain, bloating
nausea and vomiting
no bowel movements and decreased sound
inability to tolerate meals
uniform gas distribution, air filled levels
Term
treatment of paralytic ileus
Definition
IVF, NPO, stop opioids
erythromycin, neostigmine, or metoclopramide
NG suction if persists
Term
how long does post-op ileus typically last
Definition
5d
SI 24h
stomach 48-72h
LI 3-5d
Term
what disease is celiac disease associated with
Definition
down syndrome
Term
what antibodies are used to diagnose celiac
Definition
transglutaminanse and endomysium
glidian is less specific and no longer used
Term
what is seen on endoscopy in celiac
Definition
flattened villi, crypt hyperplasia
Term
treatment of tropical sprue
Definition
folic acid
tetracycline or sulfa for 3-6mo
Term
signs of whipple disease
Definition
white european male, dementia, diarrhea, bloating, steatorrhea, vision abnormalities, new murmur, wasting, myoclonus, arthritis, hyperpigmentation, weight loss

foamy macrophages on PAS stain, villi atrophy, sudan positve for fat, abnormal d-xylose
Term
treatment of whipple disease
Definition
TMP-SMX or cephtriaxone 12mo
Term
treatment of appendicitis (infection)
Definition
ampicillin/sublactam
piperacillin/tazobactam
tacaricillin/clavulanate
levofloxacin + metronidazole
metronidazole + cephalosporin

severe: ampicillin + levofloxacin + metronidazole OR imipenem/cliastatin OR mirapenem
Term
bugs causing infection in appendicitis
Definition
bacteroides, E. coli, pseudomonas
Term
signs of carcinoid syndrome
Definition
flushing, diarrhea, sweating, bronchospasm, wheezing, abdominal pain, right heart dysfunction JVD, murmurs
urinary 5-HIAA, serum serotonin, octreotide sinctigraphy to localize
Term
treatment of carcinoid syndrome
Definition
resection, if not..
octreotide: symptomatic relief
INFa: symptomatic relief alt
crytoheptadine: for diarrhea and anorexia
albuterol: for asthma
cholestyramine: for diarrhea
valve surgery
Term
causes of large bowel obstruction
Definition
#1 cancer
#2 diverticulitis
#3 volvus
Term
signs of large bowel obstruciton
Definition
feculent vomiting
high pitched bowel sounds or none
abdominal distension and pain
Term
treatment of constipation
Definition
if >10cm decompress immediatly due to risk of rupture
if has HTN or tachycardia admit and give IVF, dont give motility or antinausea medications, make NPO
Term
FAP: gene, signs, when to get colonoscopy, tx
Definition
APC, hundreds of colon adenomas, begin colonoscopys at puberty, colectomy before 25yo
Term
gardner syndrome: gene, signs, when to get colonoscopy, tx
Definition
APC
colon polyps, osteomas, dental abnormalities, benign soft tissue tumors, desmoid tumors, sebaceous cysts
begin colonoscopy at puberty
prophylactic colectomy before 25yo
Term
turcots syndrome: gene, signs, when to get colonoscopy, tx
Definition
APC
colon polyps, medulloblastoma, glioblastoma multiform
begin colonoscopy at puberty
prophylectic colectomy before 25yo
Term
putz jeger syndrome signs
Definition
benign harmatomas, pigmented spots around lips and oral mucosa, face, genitalia
cancer: stomach, ovary, breast, cervix, testicle, lung
risk of intussception
Term
familial juvenile polyposis coli signs
Definition
10-100s harmatoms in colon, SI, stomach
GI bleeding
small risk of cancer
Term
hereditary nonpolyposis colorectal cancer - lynch 1 signs, tx
Definition
early onset colorectal cancer, colon cancer forms from normal tissue not harmatomas
begnin colonoscopy q1-2y begining at 20yo or 5y before earliest family case
Term
hereditary nonpolyposis colorectal cancer - lynch 2 signs, tx
Definition
lynch 1 plus other cancer (female genital, skin, stomach, pancreas, brain, breast, biliary tract)
begnin colonoscopy q1-2y begining at 20yo or 5y before earliest family case
Term
tumor marker for colon cancer
Definition
CEA
Term
staging of colon cancer
Definition
A/1: confined to bowel wall
B/II: penetrates into colonic serosa of perirectal fat
C/III: node involvement
D/IV: distant metastasis
Term
treatment of colon cancer
Definition
right/left colon: right/left hemicolectomy

sigmoid/proximal rectum: anterior resection and anastomosis to rectal stump

within 5cm of anal verge: abdominal perianal resection and colostomy

dissect 12 regional nodes, if any are positive also gets chemo
Term
follow up for colon cancer
Definition
guiac yearly, CEA q3mo for 3y, CT body yearly, colonoscopy at 1, 3, and 5, years
Term
#1 location of mets for colon cancer
Definition
portal circulation to the liver
Term
colon cancer screening
Definition
colonoscopy: 50yo or 10y before family case
FOBT: annual starting at 50yo
flexible sigmoid and double contrast barium enema: q5y
CT colonography: not recommended, better than nothing
screening stops: when life expectancy <5y or age 75
Term
what type of adenomatous polyps are worrisome
Definition
tubular have low risk, their usually pedunculated

villious have high risk and are sessile or flat
Term
treatment of diverticulitis
Definition
PO abx and NPO for 3d, then PO abx 7-10d
fluoroquinolone + metronidazole
TMP-SMX + metronidazole
amoxicillin/clavulanate
Term
angiodysplasia: signs, risk factors, location, tx
Definition
risk: aortic stenosis, vWD, ESRD
location: usually proximal wall
cherry radiating vessels on colonoscopy
tx none, observe, coagulation if hemorrhage
Term
causes/risks for acute mesenteric ischemia
Definition
arterial emboli: AFib, MI,
arterial thrombi: PAD
hypoperfusion: shock
venous thrombosis: OC, portal HTN, malignancy, panmcreatitis
vasopressors in ill or hemo unstable
Term
signs of acute mesenteric ischemia
Definition
hypotension, lactic acidosis with anion gap metabolic acidosis, tachypnea, altered mental status, non overt bloody diarrhea, abdominal distension, absent bowel sounds, peritoneal signs, feculent breath, periumbilical pain out of proportion to exam, vomiting, thumbpringing of submucosa, pneumatosis of bowel wall
Term
risks/causes of ischemic colitis
Definition
aortic/cardiac bypass, prolonged physical activity, low CO, hypercoaguability, vasoconstrictors
Term
signs of ischemic colitis
Definition
>60yo, uregnt need to defecate, LLQ pain, overt rectal bleeding, tenderness without gaurding or rebound, segmental hemorrhagic nodules and ulcers in watershed regions on colonoscopy
Term
treatment of ischemic colitis
Definition
IVF, NPO, abx to cover anaerobes and gram negatives
Term
treatment of acute mesenteric ischemia
Definition
IVF, NPO, abx to cover anaerobes and gram negatives
NG decompression
heparin and papavine
embolectomy or thrombectomy
removal of necrotic bowel
Term
signs of chronic mesenteric ischemia
Definition
abdominal angina post parandial subsiding in 2h, weight loss, nausea, vomiting, early satiety, ABDOMINAL BRUIT
Term
signs of oligive's syndrome
Definition
radiologic LBO without mechanical obstruction
nausea, vomiting, distension, constipation, labored breathing, bowel sounds present, tympanic abdomen, EVEN GAS DISTRIBUTION
Term
treatment of colonic pseudo-obstruction
Definition
IVF, electrolytes, NG decompression, neostigmine
Term
signs of colonic voluvs
Definition
colicky abdominal pain, obstipation, abdominal distension, vomiting, palpable mass, omega loop (sigmoid), coffee bean (cecal), whril sign, double bubble sign, birds beak on barium, UNEVEN GAS DISTRIBUTION

sigmoidscopy prefered for diagnosis and treatmennt
Term
signs of chrons disease
Definition
transmural, skip lesions, cobblestoning, noncaseating granulomas, apothus ulcers, watery diarrhea, anal fissures and fistulas, STRING SIGN ON BARIUM ENEMA, HLA-B27, ASCA
Term
signs of ulcerative colitis
Definition
mucosa and submucosa, continous, crypt abscesses, pseudopolyps, friable mucosa, bloody diarrhea, weight loss, frequent small BM, tenesmus, LEAD PIPE SIGN DUE TO HASTURA LOSS, P-ANCA
Term
complications and associated conditions with chrons disease
Definition
malabsorption: B12, bile acids
fistulae, fissures, abscesses, SBO
cholelithiasis
nephrolithiasis
erythrma nodosum
Term
complications and associated conditions with ulcerative colitis
Definition
cholangiocarcinoma
colorectal cancer
malabsorption: Fe, electrolytes
TOXIC MEGACOLON #1 COD
LBO, hemorrhage, stricture
sclerosing cholangitis
ankylosing spondylitis
pyoderma gangrenosum
Term
signs and treatment of hemmhorids
Definition
internal: painless
external: thrombosed painful and swollen, felling of incomplete defecation, painful BM, puritis
Term
anal cancer: risk factos, type, signs, complication
Definition
HPV, anal intercourse, smoking, HIV
SCC
bleeding, pain, visual growth
mets to inguinal nodes
Term
where is the normal location of anal fissure, what does it mean if it isnt there
Definition
usually posterior midline
if midline suggests chrons, infection, or chancer
Term
treatment of anal fissure
Definition
stool softener, hydration
topical nitro
warm stiz bath
diltiazem, nifedipine, bethanechol cream
botox injection
partial sphincterotomy
Term
risk factor for ischiorectal abscess
Definition
HIV, necrotizing risk DM, internal hemorrhoids
Term
risk factors for fistula-in-ano
Definition
chrons, anorectal abscess, diverticulitis, foreign body reaction, infection, radiation, HIV
Term
pilonidal disease signs
Definition
cutaneous sinus tract superior midline gluteal cleft due to obstruction of tracts by hair or debris leading to cysts and abscess
mild pain with drainage, small cysts and progress to abscess
Term
LFTs for alcoholic liver damage
Definition
AST:ALT >2:1
Term
how can you make sure ALK-P is really talking about hepatobilliary
Definition
if GTT is elevated too
Term
if ALT/AST are super high and ALK-P isnt what should you suspect
Definition
hepatic necrosis
Term
which hepatitis is a retrovirus
Definition
B
Term
which hepatitis causes hepatocellular carcinoma
Definition
B
Term
which hepatitis causes cirrhosis and hepatitis
Definition
C
Term
how does hepatitis C infect
Definition
coats itself with LDL to enter hepatocytes
Term
which diseases is hep B associated with
Definition
polyarteritis nodosa and membranous nephropathy
Term
which diseases is hep C associated with
Definition
cryglobinemia, membroproliferative GN, lymphoma, thyroiditis, prophyria cutanea tardia, lichen planus, DM
Term
how does hep D infect
Definition
co infection: transmitted with B
superinfection: transmitted after B
Term
which hepatitis can be fulminent, what does that mean
Definition
B, D, E
hepatic encephalopathy, hepatorenal syndrome, bleeding diathesis
Term
how is hep B diagnosed in the window period
Definition
core antigen, viral load
Term
how is hep C diagnosed
Definition
viral load, antibodies take a long time to see
Term
how is hepatitis B and C treated
Definition
B: INFa or lamivudine
C: INFa and ribivarin, INFa alone in pregnancy
Term
how is fatty liver disease treated
Definition
pioglitazone improves LFTs and inflammation
avoid alcohol, control glucose, loose weight
metformin
Term
what are the top causes of cirrhosis
Definition
alcohol #1, hep C #2, hep B, acetminophen, methotrexate, autoimmune hepatitis, PBC, wilsons, ATT, hematochromatosis
Term
how are esophageal varices treated
Definition
EGD and ligation or octreotide, prevent with BB
Term
bugs causing peritonitis in cirrhosis
Definition
#1 E. coli, #2 klebsiella, s. pneumo
Term
treatment of hepatic encephalopathy
Definition
laculose excretes ammonia in colon, rifamaxin/neomycin kills bowel flora making ammonia
Term
what is the #1 COD in cirrhosis
Definition
esophageal varices
Term
what causes SAAG <1.1
Definition
nephrotic syndrome, pancreatitis, pseudomyxoitia peritonei (mucin producing tumor of appenxix), serositis, peritoneal carcinomatosis, peritoneal TB
Term
what causes SAAG >1.1
Definition
portal HTN: cirrhosis, hepatitis, heart failure, constrictive pericarditis, hepatic metastasis, budd-chiari
Term
when do you do a transjugular intrahepatic protosystemic shunt
Definition
patients with liver failure and bleeding that is continued despite medical and endoscopic treatment
Term
when do you do a decompressive surgical shunt in liver disease
Definition
end stage disease with surgical bleeding to prevent rebleeding, can cause hepatic encephalopathy
Term
signs of wilsons disease
Definition
kayser fleischer rings, parkinsonian (resting tremor, rigidity, bradykinesia, dysphagia, drooling, incoordination), depression, personality change, psychosis, nephrocalcinosis

LOW CERULOPLASMIN, LOW/NORMAL TOTAL CU, HIGH FREE CU, HIGH URINARY CU, livery biopsy with copper
Term
treatment of wilsons disease
Definition
d-penicillamine, zinc to prevent Cu uptake, B6, liver transplant
Cu restriction (organ meat, shellfish, chocolate, nuts, mushrooms)
Term
sighs of hematochromatosis
Definition
restrictive cardiomyopathy, hepatomeagly, INCREASED RISK HEPATOCELLULAR CARCINOMA X200, DIABETES, HYPERPIGMENTATION, impotence, testicular atrophy, arthritis

HIGH FE, FERRITIN, TRANSFERIN SATURATION, LOW TBIC, biopsy of liver with high Fe in hepatocytes
Term
treatment hematochromatosis
Definition
phlebotamines, avoid alcohol, deferoxamine
Term
cause of autoimmune hepatitis
Definition
type 1: anti-smooth muscle ab
type 2: anti-LKM (liver, kidney, microsome), anti-liver cytosol
Term
risk and appearance for hepatocellular adenoma
Definition
OC, female, steroids, glycogen storage disease
incidental small mass, remove if >5cm
Term
risk and appearance of cavernuous hemangioma
Definition
OC, pregnancy, estrogen, female
very vascular, dont biopsy can cause hemorrhage, remove if >5cm
Term
risk and appearance of focular nodular liver hyperplasia
Definition
female, reproductive age
CT shows mass with central scar
Term
risk factors for hepatocellular carcinoma
Definition
hep B, hep C, vinyl chloride, thorotrast, ATT deficiency, hematochromatosis, wileons, schistosomiasis, hepatic adenoma, smoking, glycogen storage disease 1, alfatoxin from aspergillus infected food
Term
signs of hepatocellular carcinoma
Definition
weight loss, fever, malaise, diarrhea, BRUIT OVER LIVER, hepatomeagly, abd pain, jaundice, ERYTHROCYTOSIS, HYPERCALCEMIA, CARCINOID SYNDROME, HYPOGLYCEMIA, thrombosis, high cholesterol
Term
tumor marker for hepatocellular carcinoma
Definition
AFP
Term
most common metastasis to the liver
Definition
breast, lung, colon
Term
define hemobilia
Definition
blood draining into duodenum bia common bile duct due to bleeding along biliary tract, liver or ampullary region
Term
cause of polycystic liver cysts
Definition
AD, associated with polycystic kidney disease
Term
cause of hydatid liver cysts
Definition
Echinococcus granulosus or multilocularis tapeworm in right upper lobe (DONT BREAK IT CAUSES ANAPHYLAXIS)
Term
cause, sx, tx of pyogenic liver abscess
Definition
bile flow obstruction, E. coli, klebsiella, proteus, enterococcus, anaerobes

foul smelling aspirate, RUQ pain, fever, malaise, jaundice, vomiting

need to drain it
Term
amebic liver abscess cause, risks, sx, tx
Definition
E. histolytica
risk: male, homosexual, mexico

RUQ pain, vomiting, hepatomeagly, diarrhea, ANCHOVY PASTE ODORLESS ASPIRATE

metronidazole
Term
budd chiari risks
Definition
hypercoaguability, polycythemia, pregnancy, OC, infection, cancer, trauma, hepatocellular carcinoma
Term
budd chiari diagnosis
Definition
best initial: US shows inability to visualize junction of major hepatic veins with IVC, thick hepatic veins and abnormal flow

gold standard: hepatic venography
Term
budd chiari treatment
Definition
anticoagulation, thrombolytics, and diuretics
shunt if refractory
Term
signs of unconjugated hyperbilirubinemia
Definition
indirect
tight on albumin
toxic
can cross BBB
Term
signs of conjugated hyperbilirubinemia
Definition
direct
loose on albumin
water soluble
non toxic
makes urine dark and poo pale
Term
causes of unconjugated hyperbilirubminemia
Definition
hemolysis
erythropoesis
internal hemorrhage reabsorption
physiologic of newborn
gilberts
crigler-nijjar
Term
causes of conjugated hyperbilirubinemia
Definition
dubin johnson
rotor
hepatocellular disease
drug (OC)
intrahepatic bile duct (PCS, PSC)
gallstone obstruction
pancreatic or biliary cancer
biliary atresia
Term
gilbers cause, sx, tx
Definition
mild glucuronosyl-transferase deficiency, mild jaundice after fast, exercise, stress
no treatment
Term
crigler-najjar 1 cause, sx, tx
Definition
AR severe deficiency in glucuronosyl transferase
persistent jaundice, kinicterus

phototherapy, plasmophoresis, transplant
Term
crigler-najjar 2 cause, sx, tx
Definition
AR mild glucuronosyl transferase deficiency
mild jaundice after fast, exercise, stress

phenobarbital induces hepatic synthesis of enzyme
Term
sx dubin johnson
Definition
abdomin pain, fatigue, jaundice, scleral icterus, black liver
INCREASED CORPOPRPHYRIN I BY 80% AND III BY 20% IN URINE
CANNOT SEE GALLBLADDER ORAL CHOLECYSTOGRAM
Term
rotor syndrome signs
Definition
INCREASED COROPORPHYRN III BY 80% AND I BY 2-% IN URINE
Term
cause and signs cholestasis
Definition
blockage of bile flow increases bilirubin levels causing malabsorption of fat and fat soluble vitimins

puritis, xanthomas, dark urine, pale stool, jaundice
Term
cause and signs, tx of cholelithiasis
Definition
stone in gallbladder

biliary colic, RUQ pain, boas sign (Refered to R scapula), vomiting, indigestion, flatulence

diet modification, bile salts, cholecystectomy if recurrent
Term
gallstone ileus sx, cause, dx
Definition
gallstone enters bowel lumen via cholecystoenteric fistula and gets stuck in termina ileum causing obstruction

episodic obstruction, old woman, vague recurrent abdominal pain, vomiting

CT with pneumobilia, visualized stone in bowel, dilated loops proximal to obstruction
Term
acute cholecystitis cause, sx, tx
Definition
obstruction of cystic duct causes inflammation of gallbladder wall

RUQ pain, radiation to scapula, nausea, murphys sign, palpable gallbladder, low fever, leukocytosis, US showing thick gallbladder and sludge, HIDA positive

ECRP to remove any stones, cholecystectomy within 48h, IVF, NPO, ABX
Term
choledocholithiasis cause, sx, tx
Definition
gallstone in common bile duct
jaundice, courvoisiers sign, NO FEVER OR LEUKOCYTOSIS

ERCP AND SPHINCTEROTOMY WITH STONE EXTRACTION AND STENTING
Term
cholangitis case, sx
Definition
infection of biliary tract secondary to obstruction

RQU pain, jaundice, fever, septic shock, altered mental status, hyperbilirubinemia, leukocytosis, high amylase
Term
cholangitis diagnosis
Definition
HIDA is most sensitive
US detects obstruction
ERCP is best to confirm
Term
cholangitis treatment
Definition
IV ABX
ERCO and drain ducts
cholecystectomy follows
Term
signs of adenocarcinoma of gallbladder
Definition
gallstones, gallbladder infections, CALCIFIED PORCELAIN GLALLBLADDER, jaundice, biliary colic, RUQ mass, pain radiating to back, AMPILLARY CANCER CAN BLEED INTO GI TRACT, hyperbilirubinemia
Term
signs primary sclerosing cholangitis
Definition
p-ANCA, associated with uc
string of pearls on ERCP
jaundice, puritis, fatigue, xanthomas, portal HTN, liver failure, cirrhosis
Term
signs primary biliary cirrhosis
Definition
ANTI-MITOCHONDRIAL AB
HYPERCHOLESTEROLEMIA
associated with autoimmune diseases
fatigue, puritis
HYPERPIGMENTATION
ZANTHELASMA/XANTHOMAS
dermatographism
RUQ PAIN
steatorrhea, malabsorption, hepatomeagly
Term
causes of secondary sclerosing cholangiits
Definition
intraductal stones, trauma, chemotherapy, AIDS, autoimmune pancreatitis
Term
treatment of primary biliary cirrhosis
Definition
ursodeoxycholic acid: delays progression and enhances survival
Term
cholangiocarcinoma: 3 types
Definition
bile duct adenocarcinoma

klatiskin tumor when in proximal 1/3 of CBD and causing confluence of hepatic ducts

distal extrahepatic: best for resection

intrahepatic: least common
Term
cholangiocarcinoma: risk factors
Definition
70s, primary sclerosing cholangitis, UC, choledochal cysts, chloronichis sinenisis, opisthorchis viverrini, cholelithiasis
Term
cholangiocarcinoma signs and diagnostic method
Definition
obstructive jaundice, weight loss, RUQ pain, CEA, CA 19-9

PCT/ERCP to determine resectability
usually found on US
Term
choledocal cysts cause and tx
Definition
cystic dilation of biliary tree due to duct obstruction

resect and restore proper connections
Term
bile duct stricture cause and tx
Definition
iratogenic injury leading to recurring choledocholithiasis, chronic pancreatitis, and PSC

treat with stenting or bypass
Term
biliary dyskinesia cause, dx, tx
Definition
motor dysfunction of sphincter of oddi causes biliary coli without gallstones

diagnosis with HIDA

tx cholecystectomy or sphincterotomy
Term
causes of acute pancreatitis
Definition
#1 gallstones
#2 alcohol
#3 post-ERCP
#1 kids abdominal trauma
other: didanisine, furosemide, hcTZ, valproic acid, azathioprine, estrogens, sulfa, hypercalcemia, hyperTG, cosackie B, mumps, scoroion bite, pancreatic divisium, pancreatic cancer, uremia
Term
signs of pancreatitis
Definition
epigastirc and midabdominal pain after meal, constant, radiating to back, nausea, vomiting, rebound tenderness of epigastrum

elevated amalyase and lipase (more specific), LFTs

sintenial loop (air filled bowel), colon cut off sign (Air filled transverse colon), pleural effusions, hemidiaphragm elevation, thoracentesis with high amalyase
Term
most accurate imaging for pancreatitis
Definition
CT
Term
treatment of acute pancreatitis
Definition
NPO, IVF, NG suction, pain control with fentanul/meperidine because morphine increases oddi pressure
Term
signs of hemorrhagic pancreatitis
Definition
rapid onset epigastric pain, radiating to back, worse supine and after meals, paralytic ileus, vomiting, abdominal distension
low grade fever, tachycardia, hypotension, shock
GRAY TURRNER SIGN: flank ecchymosis
CULLENS SIGN: periumbilical echymosis
FOXS SIGN: inguinal lig ecchymosis

LOW HEMATOCRIT
high amalyase and lipase
metabolic acidosis
Term
what is ransons criteria on admission
Definition
on admission with pancreatitis if glucose >200, >55yo, LDH >350, AST >250, WBC >16 then prognosis is bad
Term
treatment of hemorrhagic pancreatitis
Definition
NPO, IVF, electrolytes, NG suction, fentanyl/mepiridine
ICU with TPN
prophylactic antibiotics (imipenem)
daily CT scans
Term
signs tx of suppurlative pancreatitis
Definition
acute or hemorrhagic pancreatitis with a CT showing collection of puss and leukocytes

abscess drainage, daily CT scans
Term
what is ransons criteria in 48h
Definition
Ca <8, HCT >10% decrease, PaO2 <60, BUN >5 increase, base deficit >4mL, fluid sequestration >6L
3+ indicates poor prognosis
Term
treatment of pancreatic necrosis
Definition
sterile: resolves spontaneously, prophylactic antibiotics to avoid infection

infected: surgical debridement and abx
Term
pancreatic pseudocyst cause, sx, tx
Definition
encapsulated ensyme rich fluid 2-5wk post pancreatitis without epithelial lining

usually asymptomatic, epigastric pain, fever, palpable, increased amylase, aspirate with high amylase, leukocytosis

<6cm <6wk observe, >6cm >6wk drain percutaneous or surgically int GI or stomach
Term
pancreatic pseudo aneurysm cause
Definition
digestion of adjacent tissue and blood vessel and bleeding into pancreatic pseudocyst
Term
causes of chronic pancreatitis
Definition
#1 alcoholis, narcotics, DM, hereditary, tropical pancreatitis, idiopathic
Term
signs of chronic pancreatitis
Definition
fibrosis, epigastric pain worse with food, radiating into back, nausea, vomiting, malabsorption, steatorrhea, cosntipation, recurring acute pancreatitis

calcifications of pancreas, enlargement, pseudocysts, LOW FECAL ELASTASE IS MOST SPECIFIC AND SENSITIVE
Term
pancreatic cancer location, risk factors
Definition
usually on head

tobacco, DM, family history, chronic pancreatitis, high fat diet, male, bese, sedentary, AA, >60, alcoholism, b-naphthylamine, bzidine
Term
pancreatic cancer signs
Definition
abdominal pain radiating to back, anorexia, nausea, vomiting, weight loss, courvoisers sign if at head, splenomeagly if at tail, painless jaundice early then painful later
MIGRATORY THROMBOPHLEBITIS (TROSSEAU SYNDROME)
Term
pancreatic cancer tumor marker
Definition
CEA, CA19-9
Term
most specific and sensitive test for pancreatic cancer diagnosis
Definition
ERCP specific
CT most sensitive
Term
treatment of pancreatic cancer
Definition
whipple: removal of pancreatic head, duodenum, proximal jejunum, common bile duct, gallbladder, distal stomach
Term
most common type of tracheoesophageal fistula
Definition
esophageal atresia with distal esophageal fistula: blind pouch in upper esophagus and fistula between lower esophagus and tracheobronchial tree
Term
signs of tracheoesophageal fistula
Definition
associated with VATER, salivation, choking at first feed, coughing, cyanosis, abdominal distension with air, aspiration pneumonia, malnutrition. NG tube curls in upper chest, imperforate anus, drooling (when esophageal atresia)
Term
how is imperforate anus treated
Definition
repair delayed to any time before toilet training if fistula, if no fistula colostomy done for high rectal pouches then later repair, primary repair if blind pouch is almost at anus
Term
congenital diaphragmatic hernia signs
Definition
hernia on left and bowel in chest leads to hypoplastic lung with fetal type circulation

respiratory distress in 1st 24h, circulatory insufficiency, bowel sounds in anterior thorax, scaphoid abdomen, shift cardiac sounds to right, lung hypoplasia, air filled bowel loops in left chest, mediastinum shift left
Term
treatment of congenital diaphragmatic hernia
Definition
1) NG decompression
2) intubation and ventilation
3) surgical correction
Term
gastroschisis cause, tx
Definition
gastric contents pushed out, no protective membrane, angry matted bowel

obtain vascular access for parenteral nutrition, immediate surgical repair, bowel will work within 1mo
Term
omephalocele cause, tx
Definition
bowel sticking out, cord goes to defect that has thin membrane with normal bowel

small defects close paimairly, large require constriction of stiastic silo to protect bowel and push it in a bit every day for a week
Term
risk factors for gastroschisis
Definition
cocaine, meth, aspirin, ibprofen, young mother
Term
extrophy of bladder cause, sx, tx
Definition
abdominal wall defect over non fused pubis
medallion of red bladder mucosa, wet shining urine

transfer for repair within 1-2d of life
Term
duodenal atresia signs
Definition
assoc down syndrome

green vomit, <1mo (usually within first few hours), double bubble, duodenal stenosis, midgut bolbus
Term
midgut volvus signs
Definition
<1MO, green vomit, BLOOD PER RECTUM, abdominal pain, obstruction
barium swallow with CORKSCREW coiled
double bubble at duodenum due to obstruction
Term
intestinal atresia signs
Definition
green vomit, associated with genital abnormalities, multiple air filled fluid levels in abdomen
Term
necrotizing enterocolitis signs
Definition
mucosal necrosis and epithelial sloughing in preme

feeding intolerance, distension, low platelets, bilious vomit, lethargy, poor feeding, diarrhea, hematoschezia, shock, metabolic acidosis, air in bowel wall, portal vein gas or free air
Term
treatment necrotizing enterocolitis
Definition
TPN, NG suction, ABX, IVF, surgical intervention if wall erythema, air in portal vein, intestinal pneumatosis, pneumoperitoneum
Term
signs of meconium ileus and tx
Definition
feeding intolerance, vilious vomiting
dilated loops of small bowel, ground glass lower abdomen, gastrografin enema with microcolon, pelets in terminal ileum

gastrografin dissolves it
Term
risk factors for intussception
Definition
meckel diverticulum, henoch scholein purpura, adenovirus, peyers patch inflammation, CF, adults cancer
Term
diagnosis of intussception and tx
Definition
barium or air enema is diagnostic and theraputic
Term
signs neonatal jaundice is pathological
Definition
in 1st 24h
rise in bili >0.5 mg/dL/h
rise in bili >5mg/dL/d
direct >20% of total or >1.5
total >13 if term
jaundice after 2-3wk old
Term
physological jaundice of the newborn cause, sx
Definition
does not have enough udgt enzyme yet
starts day 2-3, peaks at <10 dL on day 3-5, resolves in 2wk, jaundice should not pass nipple line
Term
exaggerated pysiologic jaundice of newborn cause, sx, tx
Definition
has physiological jaundice and is drink breast milk that isnt ready yet and is dehydrated
starts 1wk, peaks 12-15mg/dL due to dehydration
make sure >10 feeds/d, phototherapy
Term
breast milk jaundice cause, signs
Definition
due to substances in the milk
starts days 4-14, continues for wks-mos while breastfeeding, improves with formula for 48-72h (diagnostic)
Term
biliary atresia cause signs
Definition
biliary tract fails to canalize
jaundice 2wk after birth, pale stools
direct >20% of total which is 6-12
Term
cause of kernicterus
Definition
deposition of bilirubin in basal ganglia and hippocampus that may cause permanent damage due to high bilirubin in infants
Term
define failure to thrive
Definition
weight <3rd percentile or >1 occasion
weight <80% ideal for age
crosses 2 major percentiles on growth chart
weight to length <10th percentile
rate daily weight gain less than expected for age
Term
layers of abdominal wall
Definition
epidermis and dermis
SC/hypodermis
campers fascia
scarpas fascia
external oblique
inernal oblizue
rectus abdominus
transverse abdominus
pyrmidalis
fascia transversalis
peritoneum
Term
arcuate line
Definition
linea semicircularis, douglas liine

superior to it: internal oblique aponeurosis splits to envelop rectus abdominus

inferior to it: internal oblique and transverse abdominus aponeurosis merge anterior to rectus abdominus
Term
sliding hernia
Definition
contains organ
Term
armands hernia
Definition
contains appendix
Term
litteres hernia
Definition
contains meckels diverticulum
Term
ricthers hernia
Definition
only has portion of bowel circumference, high strangulation risk
Term
indirect inguinal hernia
Definition
through deep inguinal ring, lateral to inferior epigastrics, due to congenital defect to processus vaginalis or lifting
Term
direct inguinal hernia
Definition
through hesselbachs (lateral rectus abdominus, inferior epigastric latera, inguinal lig)
acquired in old men
Term
umbilical hernia treatment
Definition
if not closed before 8yo then close surgically (usually 4-8yo)
Term
spigelain hernia
Definition
semilunar line lateral to rectus at junction of douglas due to fascial deficit
high incidence incarceration
Term
complications of obturator hernia
Definition
intermittent bowel obstruction, paresthesias of anterior medial thich (howship rhomberg sign)
Term
grynfelts hernia
Definition
wide mouth at superior lumbar triangle
low risk incarceration
Term
petitis hernia
Definition
wide mouth at inferior lumbar triangle
low risk of incarceration
Term
treatment of asymptomatic hernia
Definition
decrease intrabdominal pressure before elective surgery (BMI <35, decrease COPD, no ocnstipation, pregnancy, ascites, urinary obstruction)
Term
cholanal atresia cause, signs
Definition
blockage of nasal passage

unable to pass NG tube, no gastric distension, respiratory distress if bilateral, discharge if unilateral
Term
electrolyte changes in pyloric stenosis
Definition
hypochloremic, hypokalemic, metabolic acidosis
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