Term
| Name 3 constitutional sx in a pt presenting w/ hepatitis. |
|
Definition
| Malaise, anorexia, and fever |
|
|
Term
| Name 3 clinical sx of jaundice. |
|
Definition
| Nausea, abd pain, and jaundice |
|
|
Term
| What is route of transmission of hepatitis A? What is a major risk factor? |
|
Definition
| Fecal-oral. International travel. |
|
|
Term
| What is the diagnostic test for Hep A? |
|
Definition
| IgM Ab against HAV 5-10d /p exposure and elevated LFTs |
|
|
Term
|
Definition
| No, only acute, self-limited infxn. |
|
|
Term
| What is the route of transmission of HBV? What are risk factors? |
|
Definition
| Blood/STD. Unprotected sex, MSM, tattooing, IVDU, healthcare workers,perinatal transmission. |
|
|
Term
| What complication of HBV has a 60% mortality rate and is the massive necrosis of hepatocytes? |
|
Definition
|
|
Term
| The chronic (carrier) state of HBV is most common in who? Are LFTs abnormal? |
|
Definition
| Immunodeficient, IVDU, HD pts. Normal LFT. |
|
|
Term
| What are the sx of chronic persistent hepatitis? |
|
Definition
| Asymptomatic, self-limited. Will have elevated AST/ALT. |
|
|
Term
| Describe the hepatic sx of chronic active (aggressive) hepatitis? How is it diagnosed? |
|
Definition
| Chronic inflammation w/ hepatocyte destruction (cirrhosis and liver failure), elev. LFTs. Liver bx. |
|
|
Term
| 25% of cases of fulminant hepatitis are caused by what? 50% are caused by what? |
|
Definition
| Hepatotoxic drugs (acetaminophen). Hepatitis A-E. |
|
|
Term
| How is the route of transmission for hep C? Risk factors? |
|
Definition
| Blood/STD. Being a slut or anything associated w/ being in prison. |
|
|
Term
| Name 5 factors associated w/ HCV disease progression. |
|
Definition
| 1)>40yo at dx 2)Male 3)High Etoh use 4)Daily marijuana 5)Viral co-infection (HIV, HBV) |
|
|
Term
| Name 3 indications for antiviral tx for HCV. |
|
Definition
| 1)>18yo 2)(+) anti-HCV & HCV RNA 3)Liver bx showing chronic hepatitis |
|
|
Term
| What is the antiviral for HCV? |
|
Definition
| Pegylated interferon alfa + ribavirin x 6mo |
|
|
Term
| What is the route of transmission for Hep D? |
|
Definition
|
|
Term
| Hep D only causes hepatitis in association w/ what? |
|
Definition
| Hep B infection (can co-infect or superinfect) |
|
|
Term
| What is the difference b/t of co-infection vs superinfection in regards to HBV/HDV? |
|
Definition
| Co-infect at same time (lower chronic rate, higher risk fulminant hepatitis). Super-HDV /p HBV (60% dev. cirrhosis). |
|
|
Term
| What is the route of transmission for hep E? Risk factors? |
|
Definition
| Fecal-oral. International travel. |
|
|
Term
| Does hep E typ. evolve into chronic hepatitis or CA? What type of pt may dev. fulminant hepatitis? |
|
Definition
|
|
Term
| A benign tumor of the liver associated w/ the use of oral contraceptives and anabolic steroids? |
|
Definition
| Liver cell (hepatic) abscess |
|
|
Term
| A benign tumor of the liver w/ large vascular endolethial-lined spaces filled w/ RBCs. |
|
Definition
|
|
Term
| A very common benign tumor of the liver w/ small white nodules. |
|
Definition
|
|
Term
| What is the most common malignant tumor? |
|
Definition
| Metastatic CA to the liver |
|
|
Term
| A malignant tumor of the liver that is caused by exposure to vinyl chloride and arsenic? |
|
Definition
|
|
Term
| Malignant tumor of the intrahepatic duct. |
|
Definition
|
|
Term
| Who does hepatoblastoma occur in? |
|
Definition
|
|
Term
| 90% of primary liver neoplasms are ____. |
|
Definition
|
|
Term
| What is HCC strongly associated with? (5) |
|
Definition
| HBV, cirrhosis, alfatoxin B (fungus), androgens, and oral contraceptives. |
|
|
Term
| What lab finding is present in 50-90% of pts w/ HCC? |
|
Definition
|
|
Term
| Name 6 s/sx associated w/ HCC. |
|
Definition
| Tender hepatomegaly, ascites, wt loss, fever, polycythemia, and hypoglycemia. |
|
|
Term
| What is the typical cause of death in HCC? |
|
Definition
| GI bleed and liver failure |
|
|
Term
| Which of the hepatitis viruses have a vaccine? |
|
Definition
|
|
