Term
|
Definition
Block Nm and Nn receptors
Ability to block all autonomic outflow |
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Term
|
Definition
Binary amine that is non-selective for sympathetic/parasympathetic sites
Higher degree, further extent of effect |
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Term
| Tissues primarily under parasympathetic tone |
|
Definition
Heart: Atria and SA node
Eye: Iris and Ciliary muscle
GI tract, Urinary, salivary |
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Term
| Tissues under sympathetic tone |
|
Definition
Ventricles
Sweat glands
Blood vessels |
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Term
| Clinical apps of Ganglionic blockers |
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Definition
Not many uses because of extensive side effects
Emergency hypertension
Bloodless surgical field (hypotension) |
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Term
| Neuromuscular antagonists |
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Definition
| Block Nm receptors on post-synaptic muscle end plate |
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Term
| Non-Depolarizing Nm blockers |
|
Definition
CURARIFORM DRUGS
Induce muscle weakness and paralysis
Not CNS-absorbed
Competitive reversible inhibition of ACh at Nm |
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Term
| Other effects of Non-Depolarizing Nm antagonists |
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Definition
| Stimulate histamine release, have nonselective blocking of Nm or M receptors |
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Term
| Drugs that prolong curariform action |
|
Definition
| Aminoglycosides, inhalation anesthetics, tetracyclines, CCBs |
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Term
| Curariform Overdose treatment |
|
Definition
ACHesterase inhibitors
Sugammadex (forms cone that envelops drug) |
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|
Term
| Non-depolarizing Nm antagonist uses |
|
Definition
1. Decreased spasm during electrotherapy
2. bronchial intubation
3. Muscle relaxation during surgery |
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Term
| DEPOLARIZING Nm Antagonists |
|
Definition
Only one:
SUCCINYL CHOLINE (super ACh)
No CNS effects
Not degraded by synaptic AChesterases but by PLASMA AChesterases |
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Term
|
Definition
Binds fairly tightly
Depolarizes muscle, causes initial fasciculations, then relaxation
SHORT DURATION |
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|
Term
| Depolarizing Nm antagonist side effects |
|
Definition
| Muscle soreness, Hyperkalcemia, respiratory paralysis, muscarinic responses |
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