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Ganglionic Antagonists
Ganglia
14
Pharmacology
Professional
11/16/2010

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Term
Ganglionic antagonists
Definition
Block Nm and Nn receptors
Ability to block all autonomic outflow
Term
Mecamylimine
Definition
Binary amine that is non-selective for sympathetic/parasympathetic sites
Higher degree, further extent of effect
Term
Tissues primarily under parasympathetic tone
Definition
Heart: Atria and SA node
Eye: Iris and Ciliary muscle
GI tract, Urinary, salivary
Term
Tissues under sympathetic tone
Definition
Ventricles
Sweat glands
Blood vessels
Term
Clinical apps of Ganglionic blockers
Definition
Not many uses because of extensive side effects
Emergency hypertension
Bloodless surgical field (hypotension)
Term
Neuromuscular antagonists
Definition
Block Nm receptors on post-synaptic muscle end plate
Term
Non-Depolarizing Nm blockers
Definition
CURARIFORM DRUGS
Induce muscle weakness and paralysis
Not CNS-absorbed
Competitive reversible inhibition of ACh at Nm
Term
Other effects of Non-Depolarizing Nm antagonists
Definition
Stimulate histamine release, have nonselective blocking of Nm or M receptors
Term
Drugs that prolong curariform action
Definition
Aminoglycosides, inhalation anesthetics, tetracyclines, CCBs
Term
Curariform Overdose treatment
Definition
ACHesterase inhibitors
Sugammadex (forms cone that envelops drug)
Term
Non-depolarizing Nm antagonist uses
Definition
1. Decreased spasm during electrotherapy
2. bronchial intubation
3. Muscle relaxation during surgery
Term
DEPOLARIZING Nm Antagonists
Definition
Only one:
SUCCINYL CHOLINE (super ACh)
No CNS effects
Not degraded by synaptic AChesterases but by PLASMA AChesterases
Term
Depolarizing mechanism
Definition
Binds fairly tightly
Depolarizes muscle, causes initial fasciculations, then relaxation
SHORT DURATION
Term
Depolarizing Nm antagonist side effects
Definition
Muscle soreness, Hyperkalcemia, respiratory paralysis, muscarinic responses
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