Term
| what binds to family 1a GPCR's? |
|
Definition
| retinal odorants, catecholamines, ATP, opiates enkephalins anandamide. |
|
|
Term
| what binds to family 1b GPCR's? |
|
Definition
| peptides, cytokines, AA's, thrombin |
|
|
Term
| what binds to family 1c GPCR's? |
|
Definition
| glycoproteins hormones (LH, TSH, FSH) |
|
|
Term
| what binds to family 2 GPCR's? |
|
Definition
| calcitonin, secretine, PTH, VIP, GnRH |
|
|
Term
| what binds to family 3 GPCR's? |
|
Definition
| Glutamate (metabotropic), Ca+, GABA |
|
|
Term
| what happens once nucleotide exchange occurs? |
|
Definition
| the alpha unit on the G protein leaves with a GTP |
|
|
Term
| what effect does PKA have on CREB and gene transcription? |
|
Definition
| it goes into the nucleus and activates gene transcription |
|
|
Term
| what state is glycogen synthase in when phosphorylated? |
|
Definition
|
|
Term
| cholera toxin targets what? |
|
Definition
| Gas by inhibiting the ATPase of the alpha subunit leading to continuous action. |
|
|
Term
| what the mech of action for Pertussis Toxin? |
|
Definition
| targets Gai by inhibiting it. |
|
|
Term
| what is the purpose of BARK? |
|
Definition
| the desensitizes the receptor when phosphorylated |
|
|
Term
| what is the purpose of BARK? |
|
Definition
| the desensitizes the receptor when phosphorylated |
|
|
Term
| what is the purpose of BARK? |
|
Definition
| the desensitizes the receptor when phosphorylated |
|
|
Term
| what is the purpose of BARK? |
|
Definition
| the desensitizes the receptor when phosphorylated |
|
|
Term
| what is the purpose of BARK? |
|
Definition
| the desensitizes the receptor when phosphorylated |
|
|
Term
| what is the purpose of BARK? |
|
Definition
| the desensitizes the receptor when phosphorylated |
|
|
Term
| what is the purpose of BARK? |
|
Definition
| the desensitizes the receptor when phosphorylated |
|
|
Term
| what is the purpose of BARK? |
|
Definition
| the desensitizes the receptor when phosphorylated |
|
|
Term
| what is the purpose of BARK? |
|
Definition
| the desensitizes the receptor when phosphorylated |
|
|
Term
| what is the purpose of BARK? |
|
Definition
| the desensitizes the receptor when phosphorylated |
|
|
Term
| what is the purpose of BARK? |
|
Definition
| the desensitizes the receptor when phosphorylated |
|
|
Term
| what is the purpose of BARK? |
|
Definition
| the desensitizes the receptor when phosphorylated |
|
|
Term
| what is the purpose of BARK? |
|
Definition
| the desensitizes the receptor when phosphorylated |
|
|
Term
| what is the purpose of BARK? |
|
Definition
| the desensitizes the receptor when phosphorylated |
|
|
Term
| how is cAMP conc. decreased? |
|
Definition
|
|
Term
| what dephosphorylates PKA |
|
Definition
|
|
Term
| what three things causes CREB activation? |
|
Definition
|
|
Term
| Phosphorylase kinase activation requires |
|
Definition
|
|
Term
| what are the two ways PKC activates transcription? |
|
Definition
It can activate MAPK phoshphorylating it
It can phosphorylate Ik-B which releases nf-kb to transcribe |
|
|
Term
| how does MAPK activation happen |
|
Definition
|
|
