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G-protein-linked 2nd messengers
Pharmacology - Autonomic Drugs
13
Medical
Graduate
06/12/2011

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Cards

Term
Alpha2
Definition
G-protein class: i
Major functions:
Decrease sympathetic outflow
Decrease insulin release
Term
Alpha1
Definition
G protein class: q
Major functions:
Increase vascular smooth muscle contraction
Increase pupillary dilator muscle contraction (mydriasis)
Term
Beta1
Definition
G-protein class: s
Major functions:
Increase heart rate
Increase contractility
Increase renin release
Increase lipolysis
Term
Beta2
Definition
G-protein class: s
Major functions:
Vasodilation
Bronchodilation
Increase heart rate
Increase contractility
Increase lipolysis
Increase glucagon release
Decrease uterine tone
Term
M1
Definition
G-protein class: q
Major functions:
CNS
enteric nervous system
Term
M2
Definition
G-protein class: i
Major functions:
Decrease heart rate
Decrease contractility of atria
Term
M3
Definition
G-protein class: q
Major functions:
Increase exocrine gland secretions
Increase gut peristalsis
Increase bladder contraction
Bronchoconstriction
Increase pupillary sphincter muscle contraction (miosis)
Ciliary muscle contraction (accommodation)
Term
D1
Definition
G-protein class: s
Major functions:
Relaxes renal vascular smooth muscle
Term
D2
Definition
G-protein class: i
Major functions:
Modulates transmitter release, especially in the brain
Term
H1
Definition
G-protein class: q
Major functions:
Increases nasal and bronchial mucus production
Contraction of bronchioles
Pruritus
Pain
Term
H2
Definition
G-protein class: s
Major functions:
Increases gastric acid secretion
Term
V1
Definition
G-protein class: q
Major functions:
Increases vascular smooth muscle contraction
Term
V2
Definition
G-protein class: s
Major functions:
Increases water permeability and reabsorption in collection tubules of the kidney
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