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Fundies test 4
12/10 anti inflammatory
27
Dentistry
Graduate
12/11/2013

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Cards

Term
What are the 3 groups of anti-inflammatory medications
Definition
nonsteroidals
steroids
biologics (targeted medications)
Term
Which NSAID blocks platelet formation irreversibly?
Definition
ASA (aspirin)
Term
What syndrome occurs when you give children under 12 aspirin?
Definition
Reye syndrome (can cause ringing in your ears)
Term
What are the major groups of NSAIDS?
Definition
salicylates
proprionic acid
oxicams
acetic acid
pyrazole
Term
What propionic acid NSAID causes pseudoporphyria in fair skinned people?
Definition
Naproxen (aleve)-COX 1 and 2 inhibitor
Term
Is aspirin or ibuprofen safer in terms of platelets?
Definition
ibuprofen is safer because it blocks platelet aggregation REVERSIBLY
Term

Oxaprozin or Ketoprofen:

 

Which proprionic acid NSAID is more toxic than effective? Which one is sometimes used for joint pain and taken daily?

Definition
Ketoprofen Oxaprozin
Term
Of the oxicam NSAIDS (meloxicam, piroxicam, and nabumetone), which one causes GI bleeding?

How often are these drugs taken?
Definition
Piroxicam

daily
Term
*Which acetic acid NSAID is very strong, can used to treat Still's disease, arthritis, and inflammation but causes GI bleeding
Definition
Indomethacin
Term
What is pyrazole NSAID that is a COX-2 inhibitor that down regulates prostaglandins in the endothelium, people got more heart attacks and clots, and good to use only if person does not have a heart condition?
Definition
Celecoxib
Term
What would you use for the following (codeine, naproxen, ibuprofen, morphine or ketorolac tromethamine/toradol)?

Pain, but not undergoing surgery
Pain and undergoing surgery
A lot of pain
Definition
ibuprofen (rake 2, taking more won't give more pain control but will make it last longer) - ibuprofen gives better pain control than codeine

naproxen

toradol (gives equal pain relief as morphin and stronger through an IV)- don't use toradol more than 3 consecutive days
Term
What drugs should you NOT give to a patient undergoing surgery?

What drug should you NOT give a patient with asthma and nasal polyps?
Definition
ibuprofen and aspirin (can give naproxen instead)

aspirin (can increase asthma)
Term
What are the different types of steroids?
Definition
Mineralocorticoids (blood pressure)
glucocorticoids (stress)
androgens and estrogens
Term
What happens when people take steroids for a long time? (ex: lupus patients)
Definition
they get infections easier, they cannot fight them
Term
What are the 2 places that steroids act?
Definition
they block inflammation (block lipids going to arachidonic acid)

they get into the nucleus of the cell to block transcription/translation of certain genetic material

(makes it longer to heal because blockin collagen synthesis)
Term
What drug is the standard when comparing relative doses and equivalent potencies of glucocorticoids?
Definition
hydrocortisone (more mineralocorticoid-will affect Na/K pressure channel)
Term
What are the 3 intermediate glucocorticoids?

What is their approx hydrocortisone dose, relative anti-inflammatory potency and relative sodium retain potency?
Definition
Prednisone
prednisolone
methylprednisolone

hydrocortisone dose (4-5)
relative anti-inflammatory potency (4-5)
relative sodium retain potency (0.5-0.8)
Term
In uveitis, what type of drops should you use?
Definition
steroid drops

(use antibiotics before)
Term
What may you see in the mouths of patients who inhale steroid for asthma?

Patients who use steroid drops in their eyes?
Definition
thrush

cataracts

(steroids can also restrict growth and cause edema, acne)
Term
What syndrome is it when patients taking steroids get hypertension, become fatter, moon face, buffalo hump, stretch marks?
Definition
Cushing syndrome
Term
What happens when a patient (ex:lupus) decides to completely not take their steroids?
Definition
Taking steroids suppresses your own steroid production (hypothalamus and anterior pituitary) so you don't have adrenal production which can cause infection and become very sick
Term
What are the important cytokines for inflammation?
Definition
IL-1, TNF, IL-6
Term
Which cytokine is block in anti-inflammatory medication that is used mostly in systemic inflammatory conditions.
Definition
IL-1
Term
Which cytokine is blocked in arthritis, some of the vasculitis but mostly arthritis
Definition
IL-6
Term
what drug is used for arthritis but can cause granulomatous uveitis because it picks up the soluble TNF-alpha in the eye?
Definition
Enbrel
Term
What antibody is used for antibody-induced disease; it blocks cytokines of inflammation and gets rid of adult B cells that activates T cells that promotes inflammation
Definition
CD20 antibody and CTLA4
Term
What can help with TMJ disorders?

What helps with SYMPTOMS of arthritis?
Definition
systemic anti-inflammatory

nonsteroidals
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