Term
What is the mechanism of amantidine. rimantidine?
What is the use?
Which one needs to be dose for renal clearance?
What are the adverse effects? |
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Definition
Mech: blocks the M2 proton channel in viral envelope
Use: Parkinson's, Influenza A
Renal dosing: for amantidine
Adverse
CNS dopamine
Livido Reticularis
Peripheral Edema |
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Term
What is the effect of Zanamivir and Oseltamivir?
Use?
Administration
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Definition
Mech: Blocks Neuramidase causing viral aggregation
Use: A and B flue, Oseltamivir(DOC bird flue)
Admin: Zanamivir(inhaled), Oseltamavir(PO)
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Term
Mechanism of Acyclovir and Valacyclovir?
Adverse effects? |
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Definition
Mech: Substrate inhibitor that is phosphorylated by Thymidine Kinase and inhibits DNA polymerase, and DNA chain elongation
Adverse effects
Encephalopathy
Nephrotoxicity |
|
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Term
|
Definition
Encephalitis
Primary Herpes
Keratitis from Herpes
Mucocutaneous
Varicella-Zoster |
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Term
What is the mechanism of ganciclovir?
The uses?
Adverse effects of ganciclovir? |
|
Definition
Mech: same as Acyclovir
Use: CMV Retinitis
W/ CMVAb for pneumonia in renal transplant
Adverse
Marrow Suppression |
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Term
What is mechanism of foscarnet?
What are the uses?
Adverse effects?
|
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Definition
Mech: Phosphate derivative Blocking the DNA polymerase and the RT
Use: Ganci resistant CMV Retinitis
Adverse: Reduce Renal Function |
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Term
What is the mechanism of Cidofovir?
What are the uses?
What are the adverse effects? |
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Definition
Nucleotide analog givin IV with probenecid
Uses:
CMV Retinitis
Acyclovir-Resistant Herpes
Adverse:
Nephrotoxicity must be used with probenecid
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Term
What is the mechanism of Ribavirin
When is it used?
What are the adverse effects? |
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Definition
Mechanism
Competes with GTP/ATP for RNA Polymerase
Blocks Inosine Monophosphate Dehydrogenase
(depleting GTP
Block N7 methyl transferase(RNA capping)
Use
Influenza A and B
Respiratory Synctial Virus
W/ IFN for Hepatitis C
Adverse
Teratogenic
W/ IFN Neutropenia(IFN) and Hemolytic Anemia(Ribiviren) |
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Term
| A virus is least likely to develop resistance to what anti-viral drug |
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Definition
| Ribivirin bc of the multiple sites of action |
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Term
What is the mechanism of Fomivirsen?
How is it Administered?
When is it used? |
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Definition
Anitsense to CMV mRNA needed for replication
Admin: Intravitreally
Use: CMV Retinitis |
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Term
What is the mechanism of IFN?
What are the Uses?
How is it Administered?
What are the adverse effects? |
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Definition
Inactivates(phosphorylation of) Initiation Factor
Activates Phosphodiesterase to cleave terminal aa's from tRNA
Activates Cellular Endonuclease(degrade RNA)
Uses:
Hep B
W/ Ribivirin for Hep C
Hairy cell Leukemia
Karposi Sarcoma
Vericella Zoster in cancer Patients
Herpes Keratoconjunctivitis
Administration: IM or Sub-cut
Adverse
W/ ribiviren Neutropenia(IFN) and Hemolytic Anemia(Ribiviren) |
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