Term
| What are the factors the affect drug absorption |
|
Definition
PH
Solubility
Surface Area of absorption site
Blood flow
Dissolution rate |
|
|
Term
| What factors determine bioavailibility |
|
Definition
Absorption Rate/Mode of Administration
First-pass Effect |
|
|
Term
What are the enteral and parenteral routes of administration?
Which Enterals bypass the liver?
Which Parenterals rely on bloodflow?
Which Parenterals rely on solubility?
Which can be used for large doses? |
|
Definition
Enteral
Oral
Rectal-less first pass
Sublingual-bypass first pass
Buccal-bypass first pass
Parenteral
IV
Subcut-Blood flow
IM-Blood flow, Large Doses possible
Topical-Solubility
Pulm
Intrathecal
|
|
|
Term
| How do you calculate half life and volume of distribution? |
|
Definition
Half life=0.693Vd/Cl
Vd =Dose/Initial blood Concentration |
|
|
Term
How do you determine the dosage rate?
How long will it take to reach steady state? |
|
Definition
Clearance Rate x [Steady State] desired
4-5 Half Lifes |
|
|
Term
What are the phase reactions for drug elimination?
Which completely inactivates drugs? |
|
Definition
Phase 1: unmask polar groups(OH, SH, NH2)
Phase 2: Conjugation(acids or glycine)
Complete inactivation: Phase 2 |
|
|
Term
| Factors affecting elimination of drugs by the kidney? |
|
Definition
GFR
Protein Binding Capacity
PH
Polarity |
|
|
Term
| What drugs are degraded by CYP2D6? |
|
Definition
B-block
Class I Anti-Arrythmics
Tricyclics
SSRI's, SNRI's
Opiods |
|
|
Term
| What are the major inducers of CYP3A4 |
|
Definition
Phenobarbitol
Primidone
Phenytoin
Carbamezine
NNRTI's
Rifampin |
|
|
Term
| Drugs showing flow limited metabolism |
|
Definition
| Tricyclic Antidepressants |
|
|
