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Details

Fundamentals-Pharm
Dose-Response
7
Pharmacology
Graduate
02/17/2011

Additional Pharmacology Flashcards

 


 

Cards

Term
Describe efficacy and potency on dose-effect curves?
Definition

Left shift: increases potency

Upward Shift: increases efficacy

Term
Difference between Physiological and Pharmacological Antagonists
Definition

Physio: Counter effect by different mechanism

Pharmaco: Counter effect by blocking same mechanism

Term
Mechanisms of non-competitive antagonists
Definition

Irreversibly bing receptor site

Bind Allosterically

Term
How do competitive and noncompetive antagonists affect effacacy and potentcy
Definition

Competitive: Potency decreases

Non-competitive: Efficacy Decreases

Term
What are partial and inverse agonists
Definition

Inverse: Down regulates constituatively active receptors

Partial: Exhibit effect to a lesser degree that the physiological ligands decreasing effects, but maintaining some activity

Term
What are spare receptors
Definition
Enzymatic processes are saturated before the receptors are
Term
What is the Margin of Safety and the Therapedic Index
Definition

Margin of Safety: LD1/ED99

Therapeudic Index: TD50/ED50

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