What are the reversible anti-cholinesterases?

Which is a simple competitive inhibitor?

Which has the longest half life?

Which is essentially 2 neostigmines?

Edrophonium: Dx MG(competitive inhibitor)

Physostigmine: Wide-Angle together with Pilocarpine

Neostigmine: myasthenia gravis

paralytic bladder and GI tone loss

Pyridostigmine: Myasthenia Gravis(long-acting)

Ambenonium: Longest half-life

Demecurium: Two neostigmines linked

What is the mechanism of carbamates and Organophosphates?

What are the common drugs of each class?

Organophosphates: Irreversible AchE block

Echothiophosphate(glaucoma)

Malathion

Parathion

Sarin/Soman

Carbamates: Competitive substrates with slow degradation

Neostigmine

Physostigmine

Pyridostigmine

Ambenonium

Demecarium

Nicotinic Effects in addition to Dumbbelss

Hypotension

Confusion, Agitation, Convulsions, and Coma

Paralyis and Fasciculations

What are the major anticholinesterases used in alzheimer's?

Which is the drug of choice?

Donepizil(first choice)

Rivastigmine

Galantamine(nAchR enhacer and weak AchE block)