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Fundamentals-Pharm
Sulfonamides, Trimethoprim, and Quinolones
7
Pharmacology
Graduate
02/18/2011

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Cards

Term

What are the topical Sulfonamides?

What are the uses of each

Definition

Silver Sulfadiazine: Burns

Sulfacetamide: Ocular Infections

Triple Sulfa: Vaginitis(Haemophilus vulgaris)

Term

What are the oral sulfonamides?

What are their major uses?

Definition

Sulfasoxasole: UTI's

Sulfamethoxazole: Used w/ trimethopirm for UTI's

Sulfadoxine/Pyramethamine: Malaria

Sulfadiazine/Pyramethamine: Toxoplasmosis

Dapsone: Leprosy

Sulfasalasine: IBD (5-aminosalicyclic acid)

Term

What is the mechanism of the sulfonamides?

What are the adverse effects?

What is the spectrum?

Definition

Mechanism: PABA analog Blocking Dihydropteroate Synthase

Spectrum:

Gram (+)

Gram(-)

Nocardia

Chamydia

Adverse

Hemolytic Anemia in G6P deficient patients

Kernicturus in newborns

Allergic Nephritis

Stephen Johnson

Term
Is trimethoprim or sulfonamides bacteriacidal
Definition
Neither
Term
What specific bacteria species is Trimethoprim and sulfamethoxazole used in combination for?
Definition

Pneumocystis Caryni

H. Flu Pneumonia

Strep pneumo Pneumonia

Shigella enteritis

Systemic Salmonella

Systemic Nocardia

Term

What is the mechanism of Trimethoprim

What are the major adverse effects of trimethoprim/sulfamethoxazole

How can these be prevented

Definition

Mech: Block bacterial dihydrofolate reductase

Adverse

Leukopenia

Megaloblastic Anemia

Prevention: Folate

 

Term

What is the mechanism of the Quinolones?

What substances should not be taken with the quinolones?

What are the adverse effects of the quinolones?

Definition

Mech: Inhibit Topoisomerase II and IV

Never with anacids

Adverse

Cartilage Damage

Prolonged QT

CNS disturbance

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