Term
What is order of paralysing muscles as NMJ blockers take effect
What muscle is last |
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Definition
Fast and Large muscles first
Eye->Extremities->Trunk
Diaphram last |
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Term
Mechanism of Succinyl choline
How are fasciculations prevented
What are the adverse effects?
How is it degraded? |
|
Definition
Initial depolarizing block
Desensitization block(blocking ion channel)
Fasciculations: pretreat with non-depolarizing
Adverse
Hyperkalemia-Not to children bc undiagnosed cardiomyopathies
Ocular Pressure-Not to ocular injured patients
Malignant Hyperthermia
Degradation
Plasma cholinesterases(variants, or liver damage can prolong activity) |
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Term
What are the long-acting NMJ blockers
Which exhibits Heart block?
How are they eliminated?
Which block autonomic ganglia?
Which increase Histamine release? |
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Definition
Doxacuronium
Pancuronium: Heart block
Pipecuronium
Metocurine: Hist release and Autonomic block
Tubocurarine: Hist release and Autonomic block
All are eliminated by the kidney |
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Term
What are the Intermeadiate-acting NMJ Blockers?
Which have a fast onset?
Which is eliminated by the liver and kidney |
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Definition
Atracurium
Cistracurium
Rocuronium: Fast-onset
Vecuronium: Liver and kidney |
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Term
What are the short-acting NMJ blockers
How are they degraded? |
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Definition
Mivacurium
Succinylcholine
Degradation: Plasma Esterases |
|
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Term
| If an NMJ blocker other than succinylcholine or mivacurium is used, how can reversal be accelerated? |
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Definition
Addition of Neostigmine
Also, Atropine to prevent the overshoot |
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