Term
| micrognathia, low-set ears, limited hip adduction, mental retardation, short neck, overlapping fingers; rocker bottom feet, heart defects, kidney defects |
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Definition
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Term
| microcephaly, microphthalmia, polydactyly, umbilical hernia; rocker bottom feet, heart defects, kidney defects |
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Definition
| Patau syndrome = trisomy 13 |
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Term
| blindness; PDA, pulmonary stenosis, microcephaly |
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Definition
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Term
| blindness; hepatosplenomegaly, thrombocytic purpura |
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Definition
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Term
inheritance:
1. hemochromatosis
2. G6PD deficiency
3. hereditary spherocytosis |
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Definition
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Term
| vitamin needed for collagen tensile strength and hydroxylation of prolines |
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Definition
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Term
storage disease:
1. wrinkled cell in bone marrow, hepatosplenomegaly, pancytopenia
2. mental retardation, peripheral neuropathies
3. mental retardation, motor weakness, cherry red macula
4. mental retardation, coarse facies, CAD, corneal clouding
5. mental retardation, psychomotor retardation, hepatosplenomegaly, soap bubble macrophages |
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Definition
1. Gaucher: glucocerebrosidase
2. metachromatic leukodystrophy: arylsulfatase
3. Tay Sachs: hexosaminidase
4. Hurler's: iduronidase
5. Niemann Pick: sphingomyelinase |
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Term
| cirrhosis, ascites, dependent edema are examples of... |
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Definition
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Term
| leukotriene that activates neutrophil migration, chemotactic |
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Definition
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Term
| leukotriene that causes vasoconstriction, bronchospasm, increased vessel permeability |
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Definition
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Term
| DKA and excessive sweating causes what kind of fluid loss? |
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Definition
| hypotonic salt-containing fluid loss |
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Term
| increased hydrostatic pressure causes ___ but not ___, in contrast to decreased oncotic pressure |
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Definition
| ascites but not dependent pitting edema |
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Term
1. ABL
2. HER
3. MYC
4. N-MYC
5. RAS
6. RET
7. SIS |
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Definition
1. CML
2. breast cancer
3. Burkitt's lymphoma
4. neuroblastoma
5. leukemia; lung colon pancreas
6. MEN IIa, IIb
7. osteosarcoma, astrocytoma |
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Term
1. TGF-beta ->cancer?
2. TP53 -> cancer? |
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Definition
1. pancreatic, colorectal carcinoma
2. lung, colon, breast; Li Fraumeni (breast, brain, leukemia, sarcoma) |
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Term
cancers caused by...
1. alkylating agents
2. arsenic
3. benzene
4. cyclophosphamide
5. diethylstilbestrol
6. beta-naphthylamine
7. polyvinyl chloride |
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Definition
1. lymphoma
2. liver angiosarcoma; squamous cell carcinoma of skin, lung cancer
3. leukemia
4. transitional cell carcinoma of bladder
5. clear cell carcinoma of vagina or cervix
6. transitional cell carcinoma of bladder
7. liver angiosarcoma |
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Term
protein affected by... in cancer:
1. HTLV-1
2. HPV-16, HPV-18 |
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Definition
1. activate TAX, inhibit p53
2. 16: E6 inhibits p53; 18: E7 inhibits Rb |
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Term
paraneoplastic syndromes
1. acanthosis nigricans
2. Eaton-Lambert
3. hypertrophic osteoarthropathy
4. nonbacterial thrombotic endocarditis
5. seborrheic keratosis
6. superficial migratory thrombophlebitis
7. nephrotic syndrome |
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Definition
1. stomach cancer
2. small cell lung cncer
3. bronchogenic cancer
4. pancreatic, colorectal cancer
5. stomach cancer
6. pancreatic cancer
7. lung, breast, stomach cancer |
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Term
paraneoplastic endocrinopathies
1. ACTH
2. hCG
3. PTH-RP
4. insulin-like factor
5. EPO |
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Definition
1. small cell lung cancer, medullary carcinoma of thyroid
2. choriocarcinoma of testis
3. squamous cell carcinoma, lymphoma, renal cell carcinoma
4. liver cancer
5. kidney, liver cancer |
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Term
tumor markers
1. AFP
2. CA 15-3
3. CA 19-9
4. CA 125
5. CEA
6. LDH |
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Definition
1. liver, yolk sac
2. breast
3. pancreas, colorectal
4. ovaries
5. pancreas, colorectla
6. lymphoma |
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Term
| Smoking cessation does not reduce the risk for ... |
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Definition
| hepatocellular carcinoma. |
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Term
1. short QT, wide T wave
2. peaked T wave |
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Definition
1. hypercalcemia
2. hyperkalemia |
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Term
1. 8;14
2. 9;22
3. 15;17
4. 12;21
5. 14;18
6. 11;14
7. 11;22 |
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Definition
1. Burkitt's
2. CML
3. AML (M3)
4. ALL
5. follicular B cell lymphoma
6. mantle B cell
7. Ewing's sarcoma |
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Term
1. no lipoprotein lipase, no apoCII
2. no LDL receptors
3. no apoE
4. high VLDL
5. decreased CPL |
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Definition
1. type I, eruptive xanthomas
2. type II (familial hypercholesterolemia), tendon xanthomas and xanthelasmas
3. type III (familial dysbetalipoproteinemia), palmer xanthomas
4. type IV (familiarl hypertriglyceridemia), eruptive xanthomas
5. type V, DKA, eruptive xanthomas, turbid infra and supranates |
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Term
| PAN is associated with what infectious disease? |
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Definition
|
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Term
| functions of lipoprotein lipase |
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Definition
| breaks down chylomicrons and VLDLs |
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Term
1. vWF carries...
2. protein C breaks down...
3. antithrombin inactivates... |
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Definition
1. factor 8
2. factors 5a and 8a
3. factors 2, 7, 9, 10, 11, 12 |
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Term
|
Definition
| Strep pneumo, Haemophilus influenza, Salmonella, Neisseria meningitidis |
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Term
|
Definition
| Ras, myc, ERB, sis, ABL, TGF-a |
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Term
| what is the cardiac tamponade triad? |
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Definition
| hypotension, muffled heart sounds, JVD |
|
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Term
| pericardial knock, pulsus paradoxus, Kussmaul's sign --> dx? |
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Definition
| constrictive pericarditis |
|
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Term
| serofibrinous pericarditis can follow... (4) |
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Definition
| uremia, MI, viral infection, rheumatic fever |
|
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Term
| acute heart failure, hx of viral infection -> dx? |
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Definition
| viral myocarditis -> dilated cardiomyopathy |
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Term
nephrotic or nephritic?
1. minimal change
2. thin basement membrane
3. IgA nephropathy
4. Alport's
6. focal segmental glomerulosclerosis
7. post-strep GN
8. amyloidosis
9. diabetic nephropathy
10. SLE |
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Definition
1. minimal change - nephrotic
2. thin basement membrane - nephritic
3. IgA - nephritic
4. Alport's - nephritic
5. FSGN - nephrotic
6. RPGN - nephritic
7. post-strep GN - nephritic
8. amyloidosis - nephrotic
9. diabetes - nephrotic
10. SLE - nephritic |
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Term
liver histology in...
1. a1-antitrypsin deficiency
2. reye's syndrome
3. wilson's |
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Definition
1. PAS+ globules
2. microvesicular fatty change
3. rhodamine+ cytoplasmic granules |
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Term
triads...
1. ascites, hydrothorax, ovarian fibroma
2. gastrinoma, ulcers, high HCl
3. HTN, low HR, irregular breathing
4. jaundice, fever, RUQ pain |
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Definition
1. Meig's
2. Zollinger-Ellison
3. Cushing's
4. Charcot's cholangitis |
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Term
1. MEN 1
2. MEN 2a
3. MEN 2b |
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Definition
1. hyperParathyroid, Pancreatic tumor, Pituitary tumor
2. Parathyroid tumor, Pheochromocytoma, medullary carcinoma of thyroid
3. Pheochromocytoma, medullary carcinoma of thyroid, ganglioneuroma (+marfanoid habitus) |
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Term
| port wine stain, leptomeningeal angiomatosis |
|
Definition
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Term
collagen
1. type I
2. type II
3. type III
4. type IV |
|
Definition
1. bone, skin, tendon
2. cartilage
3. reticulin (blood vessels, uterus, skin
4. basement membrane |
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