Term
| Name an industrial use for the organophosphates |
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Definition
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Term
| Name an industrial organophosphate |
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Definition
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Term
| What neurotransmitter does Sarin affect? |
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Definition
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Term
| Describe the effect Sarin has on Ach |
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Definition
| Inhibits Ach-> buildup of Ach in synapse->post syn cell in refractory period-> muscle paralysis |
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Term
| mAChR's belong to what class of nt? |
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Definition
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Term
| where is muscarine found naturally? |
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Definition
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Term
| T/F: mAChRs are metabotropic |
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Definition
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Term
| Is glutamate inhibitory or excitatory? |
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Definition
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Term
| What is the most important nt? |
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Definition
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Term
| In what division of the nervous system does glutamate act? |
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Definition
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Term
| Glutamate belongs to what general class of molecules? |
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Definition
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Term
| T/F: Glutamate is an essential amino acid? |
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Definition
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Term
| T/F: Glutamate can cross the blood brain barrier? |
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Definition
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Term
| what is the glutamate-glutamin cycle? |
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Definition
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Term
| What is the role of an EAAT? |
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Definition
| EAAT = excitatory amino acid transporter; removes glutamate from the synapse |
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Term
| How many GABA receptors are currently known? |
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Definition
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Term
| What are the ionotropic GABA receptors? |
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Definition
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Term
| What are the metabotropic GABA receptors? |
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Definition
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Term
| From where does info feed into dopamine nt's? |
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Definition
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Term
| From where does info feed into norepinephrine nt's? |
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Definition
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Term
| From where does info feed into epinephrine nt's? |
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Definition
| Medullary epinephrine neurons |
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Term
| Why is the frog a good model for the study of channels? |
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Definition
1. readily available
2. have few endogenous channels
3. large enough to permit mRNA and DNA to be microinjected with ease. |
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Term
| How large is a frog oocyte? |
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Definition
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Term
| What is a general reason Xenopus is a good model? |
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Definition
| Can combine molecular and physiological techniques |
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Term
| What is a heterologous expression experiment? |
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Definition
| insert point mutation into a foreign sequence, express it in a model to see what the function was |
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Term
| What is the proposed (physical)mechanism of voltage gating in v-dep ion channels? |
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Definition
| Vm changes so v-sense domain rotates->conformational change->only certain ions allowed to pass |
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Term
| What are the 3 catecholemines? |
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Definition
| dopamine, adrenaline, and noradrenaline |
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Term
| What are the biogenic amines? |
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Definition
| The 3 catecholamines, histamine, and serotonin |
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Term
| What are the 3 classes of opioids? |
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Definition
| endorphins, enkephalins, dynorphins |
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Term
| Which is the least abundant catecholamine? |
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Definition
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Term
| What are the 4 methods of nt deactivation? |
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Definition
| degradation, reuptake, autoreceptors, and diffusion |
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Term
| What class of molecule are the catecholamines? |
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Definition
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Term
| What is unique about ACh? |
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Definition
| it is the only small molec monoamine |
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Term
| What are the only large molec nts discussed? |
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Definition
| peptides, 5 classes: brai/gut, opiod, pituitary, hypothalamic, misc |
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Term
| What are the 5 classes of peptide neurotransmitters? |
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Definition
| brain/gut, opiod, pituitary, hypothalamic, miscellaneous |
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Term
| Name the biogenic amine nts |
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Definition
| dopamine, norepinephrine, epinephrine, serotonin, histamine |
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Term
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Definition
| aspartate, glutamate, GABA |
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Term
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Definition
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Term
| Name the 4 classes of small molec receptor |
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Definition
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Term
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Definition
| nicotinic ACh receptor (nAChR) |
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Term
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Definition
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Term
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Definition
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Term
| what are the only inhib nts mentioned in class? |
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Definition
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Term
| What are the 3 large, dense-core nts? |
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Definition
| Serotonin, Histamine, neuropeptides |
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Term
| describe the size of an ionotropic pore |
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Definition
| .6nm at widest, .3nm smallest (still much larger than other types of channels) |
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Term
| Describe the general structure of a ligand gated channel |
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Definition
| Each subunit w/ 4 trnsmemb domain or 3 + 1 pore loop; 4 or 5 subunits at a time. Also has long tail as nt binding site |
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Term
| Describe the general structure of metabotropic receptors |
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Definition
| Single subunit, 7 transmembrane domains, contain nt binding site and g-protein binding site |
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Term
| What are the structural similarities between Na and K ion channels? |
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Definition
| They are both composed of 4 subunits |
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Term
| what are the domains of Na/K ATPase? |
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Definition
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