Term
| What is the MOA of quinolones? |
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Definition
| Bactericidal - inhibit topoisomerase II ( DNA gyrase) which is responsible for negative supercoiling - leading to defect relaxation of double stranded DNA - leading irreparable DNA breakage |
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Term
| What quinolone is used to treat chlamydia? |
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Definition
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Term
| What quinolone is used to treat Gonorrhoea? |
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Definition
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Term
| What other clinical uses to quinolones have? |
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Definition
| UTI which is resistant to cotrimoxazole |
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Term
| what is used to treat drug resistant pneumococci |
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Definition
| levofloxacin/ sparfloxacin |
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Term
What is the DOC form Pseudomonas Aeurogenosa?
& also used osteomylitis |
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Definition
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Term
| What is the DOC for a pregnant female with chlamadia? |
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Definition
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Term
| What are the ADR's of quinolones? |
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Definition
Arthropathy in children ( tendon rupture- usually Achilles tendon) thus contraindicated in preg and children under 18
CNS effects - insomnia - seizures |
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Term
| What specific ADR do Sparfloxacin & Gatifloxacin have? |
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Definition
Prolonged Q-T interval (TDP)
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Term
| which Quinolones have an ADr of photosennsitivity |
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Definition
Sparofloxacin
Lomefloxacin
Pefloxacin |
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Term
| which quinolone has a specific ADR of hepatotoxicity |
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Definition
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