Term
| how do corticosteroids inhibit inflamation? |
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Definition
| they induce annexins (or Lipocortins) which inhibit PLA2, which prevents free arachidonic acid so COX/LOX can convert in "inflammatory soup" |
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Term
| describe the mechanism of steroid action and speed of action? |
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Definition
pass cell membrane, receptor binding, transport to nucleus, binding to steroid resonse element on DNA, transcription promoted, translation
Slow, >10 hours |
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Term
| 11-beta hydroxysteroid dehydrogenase 2 |
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Definition
Converts cortisol to cortisone in the kidney
Prevents overactivation of MC receptors
Is inhibited by licorice -> pseudohyperaldosteronism |
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Term
|
Definition
mineralocorticoid
AIE/MCE = 10/125 |
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Term
|
Definition
mineralocorticoid
AIE/MCE = 0/20 |
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Term
|
Definition
glucocorticoid, short acting
AIE/MCE = 1/1 |
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Term
|
Definition
glucocorticoid, short acting
AIE/MCE = 0.8/0.8 |
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Term
|
Definition
glucocorticoid, intermediate acting
AIE/MCE = 4/0.3 |
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Term
|
Definition
glucocorticoid, intermediate acting
AIE/MCE = 4/0.8 |
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Term
|
Definition
glucocorticoid, intermediate acting
AIE/MCE = 5/0.5 |
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Term
|
Definition
glucocorticoid, intermediate acting
AIE/MCE = 5/0 |
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Term
|
Definition
glucocorticoid, long acting
AIE/MCE = 35/0 |
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Term
|
Definition
glucocorticoid, long acting
AIE/MCE = 30/0 |
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|
Term
|
Definition
glucocorticoid, long acting
AIE/MCE = 10/0 |
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Term
| what makes inhaled steroids safe despite there many side effects? |
|
Definition
| only effect the lungs, because of high first pass effect the liver removes any ingested before reaching systemic circulation |
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Term
|
Definition
inhaled steroid
used for asthma |
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Term
|
Definition
inhaled steroid
used in asthma and COPD |
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Term
|
Definition
inhaled steroid
used in asthma
10% bioavailability |
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Term
|
Definition
inhaled steroid
used in asthma
20-30% bioavailability - tell patients to wash out mouth after inhalation |
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Term
|
Definition
| inhibitor of steroid synthesis |
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Term
|
Definition
| inhibitor of steroid synthesis |
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Term
|
Definition
inhibitor of steroid synthesis
antifungal |
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Term
|
Definition
inhibitor of steroid synthesis
anti-progesterone |
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Term
|
Definition
inhibitor of steroid synthesis
blocks aldosterone, reduces BP |
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Term
|
Definition
inhibitor of steroid synthesis
blocks aldosterone, reduces BP |
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|
Term
| which are the inhaled steroids ? which is the best? 2nd best? |
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Definition
| beclomethasone, fluticasone w/ salmeterol (best), budenoside (2nd), Flunisolide |
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|
Term
| Inhibitors of steroid synthesis |
|
Definition
| Spironolactone, Metyrapone, aminoglutethimide, ketoconazole, epleronone, mifepristone |
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