Term
| NMDA recepor, type of channel? effect of glycine in CNS? PNS? |
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Definition
Na and ca channel - important for NT release
CNS glycine - agonist
PNS glycine - antagonist |
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Term
| endogenous NMDA agonsists? antagonists? |
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Definition
agonists - excitatory AAs, glutamate, acetate
antagonists Zn and MG |
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Term
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Definition
-decreases excitability
SEs - decreases in HR, BP, tendon reflex, muscle force, CNS |
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Term
| Ketamine; active isomer? action? effect? SEs? |
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Definition
(S) esketamine
NMDA antagonist
potent analgesic; Sympathomimetic = increased RR, HR, BP, O2 consumption
SEs - bronchorrhea, sialorrhea, vivid dreams |
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Term
| Memantine; action? use? SEs |
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Definition
NMDA antagonist
rapid blocking/unblocking (unlike Mg)
prevention of dementia/improved mental performance
SE - bradycardia and bronchoconstriction |
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Term
| methadone; action? PK? effect? |
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Definition
1/2 NMDA antagonist and 1/2 mu-agonist
slow onset and long t1/2
analgesia and sedation |
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Term
| lamotrigine; use? action? |
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Definition
anti-epileptic
glutamate release inhibitor and Na-channel blocker |
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Term
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Definition
anti-epileptic
NMDA antagonist and GABA agonist |
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Term
| Topiramate; use? action? SEs |
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Definition
anti-epileptic
AMPA antagonist and GABA agonist
weight loss (from reduced DA release)inhibits carbonic anhydrase - makes soda taste bad, and impaired memory
"california drug" or "stupimax" |
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