Term
| NDMR (Nondepolarizing Muscle Relaxant) mode of action, effect, advantage; Don'ts |
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Definition
| binds to alpha subunit of nicotinic receptor at neuromuscular junction and prevents Na channel from opening; muscle relaxation and paralysis; no fasciculations or myalgia like SUX; Don't use if patient is awake or not intubated |
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Term
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Definition
| Isoquinolines (South American, curare/tubocurarine like) and Aminosteroids (African, malouetine like) |
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Term
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Definition
| first synthetic isoquinoline/curare like NDMR |
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Term
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Definition
| first synthetic aminosteroid/malouetine like NDMR |
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Term
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Definition
| ending for isoquinoline NMDRs |
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Term
| Isoquinoline NMDR side effects? |
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Definition
| Histamine release -> tachycardia (bad if CAD) and brochoconstriction (bad if asthma/COPD) |
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Term
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Definition
| ending for aminosteroid NMDR |
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Term
| Aminosteroid NMDR side effect? |
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Definition
| vagolytic (inhibit vagus nerve) -> increased heart rate and bronchodilation |
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Term
| Pancuronium use, metabolism, duration, side effect? |
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Definition
| Aminosteroid NMDR; hepatic and renal; long acting (60-90 min); pronounced tachycardia (most vagolytic) |
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Term
| Pipecuronium use, metabolism, duration? |
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Definition
| Aminosteroid NMDR; hepatic and renal; long acting (90-120 min) |
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Term
| Vecuronium use, metabolism, duration? |
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Definition
| Aminosteroid NMDR; kindney/renal/bile; intermediate acting (30-40 min: popular b/c duration of many procedures) |
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Term
| Rocuronium use, metabolism, duration? |
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Definition
| Aminosteroid NMDR; renal/bile only; intermediate acting (30-40 min) |
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Term
| Mivacurium use, metabolism, duration, side effect? |
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Definition
| isoquinoline NMDR; plasma ChE; shortest acting NMDR(5-15 min: but long enough to cause brain damage due to hypoxia) |
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Term
| Atracurium use, metabolism, duration, side effect? |
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Definition
| isoquinoline NMDR; 1/3 Hofmann (spontaneous) degradation, rest plasma esterases; intermediate duration (20 min: because some hepatic metabolism); laudanosine production (hepatic metabolite that stimulates CNS [NMDA agonist/GABA antagonist], can lead to seizures) |
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Term
| Cisatracurium use, metabolism, duration, side effect? |
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Definition
| isoquinoline NMDR; partial Hofmann (spontaneous) degradation, partial plasma esterases; intermediate duration (30 min: because some hepatic metabolism); laudanosine production (hepatic metabolite that stimulates CNS [NMDA agonist/GABA antagonist], can lead to seizures) |
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Term
| Doxacurium use, metabolism, duration? |
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Definition
| isoquinoline NMDR; not metabolized/renal elimination; long duration (120 min: use this or pipecuronium) |
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Term
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Definition
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